MAML1
پروتئین شبه مغز متفکر ۱ (انگلیسی: Mastermind-like protein 1) یک پروتئین است که در انسان توسط ژن «MAML1» کُدگذاری میشود.[۵][۶][۷] این پروتئین احتمالاً یک راهانداز فاکتور رونویسی در مسیر پیامرسانی سلولی Notch است.[۷]
منابع
- ↑ ۱٫۰ ۱٫۱ ۱٫۲ GRCh38: Ensembl release 89: ENSG00000161021 – Ensembl, May 2017
- ↑ ۲٫۰ ۲٫۱ ۲٫۲ GRCm38: Ensembl release 89: ENSMUSG00000050567 – Ensembl, May 2017
- ↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ↑ Wu L, Aster JC, Blacklow SC, Lake R, Artavanis-Tsakonas S, Griffin JD (Dec 2000). "MAML1, a human homologue of Drosophila mastermind, is a transcriptional co-activator for NOTCH receptors". Nat Genet. 26 (4): 484–9. doi:10.1038/82644. PMID 11101851. S2CID 23335042.
- ↑ Kitagawa M, Oyama T, Kawashima T, Yedvobnick B, Kumar A, Matsuno K, Harigaya K (Jun 2001). "A human protein with sequence similarity to Drosophila mastermind coordinates the nuclear form of notch and a CSL protein to build a transcriptional activator complex on target promoters". Mol Cell Biol. 21 (13): 4337–46. doi:10.1128/MCB.21.13.4337-4346.2001. PMC 87094. PMID 11390662.
- ↑ ۷٫۰ ۷٫۱ "Entrez Gene: MAML1 mastermind-like 1 (Drosophila)".
برای مطالعهٔ بیشتر
- Alves-Guerra MC, Ronchini C, Capobianco AJ (2007). "Mastermind-like 1 Is a specific coactivator of beta-catenin transcription activation and is essential for colon carcinoma cell survival". Cancer Res. 67 (18): 8690–8. doi:10.1158/0008-5472.CAN-07-1720. PMID 17875709.
- Zhao Y, Katzman RB, Delmolino LM, Bhat I, Zhang Y, Gurumurthy CB, Germaniuk-Kurowska A, Reddi HV, Solomon A, Zeng MS, Kung A, Ma H, Gao Q, Dimri G, Stanculescu A, Miele L, Wu L, Griffin JD, Wazer DE, Band H, Band V (2007). "The notch regulator MAML1 interacts with p53 and functions as a coactivator". J. Biol. Chem. 282 (16): 11969–81. doi:10.1074/jbc.M608974200. PMID 17317671.
- Nam Y, Sliz P, Song L, Aster JC, Blacklow SC (2006). "Structural basis for cooperativity in recruitment of MAML coactivators to Notch transcription complexes". Cell. 124 (5): 973–83. doi:10.1016/j.cell.2005.12.037. PMID 16530044. S2CID 17809522.
- Fryer CJ, White JB, Jones KA (2005). "Mastermind recruits CycC:CDK8 to phosphorylate the Notch ICD and coordinate activation with turnover". Mol. Cell. 16 (4): 509–20. doi:10.1016/j.molcel.2004.10.014. PMID 15546612.
- Nam Y, Weng AP, Aster JC, Blacklow SC (2003). "Structural requirements for assembly of the CSL.intracellular Notch1.Mastermind-like 1 transcriptional activation complex". J. Biol. Chem. 278 (23): 21232–9. doi:10.1074/jbc.M301567200. PMID 12644465.
- Wallberg AE, Pedersen K, Lendahl U, Roeder RG (2002). "p300 and PCAF act cooperatively to mediate transcriptional activation from chromatin templates by notch intracellular domains in vitro". Mol. Cell. Biol. 22 (22): 7812–9. doi:10.1128/MCB.22.22.7812-7819.2002. PMC 134732. PMID 12391150.
- Lin SE, Oyama T, Nagase T, Harigaya K, Kitagawa M (2003). "Identification of new human mastermind proteins defines a family that consists of positive regulators for notch signaling". J. Biol. Chem. 277 (52): 50612–20. doi:10.1074/jbc.M209529200. PMID 12386158.
- Fryer CJ, Lamar E, Turbachova I, Kintner C, Jones KA (2002). "Mastermind mediates chromatin-specific transcription and turnover of the Notch enhancer complex". Genes Dev. 16 (11): 1397–411. doi:10.1101/gad.991602. PMC 186317. PMID 12050117.
- Wu G, Lyapina S, Das I, Li J, Gurney M, Pauley A, Chui I, Deshaies RJ, Kitajewski J (2001). "SEL-10 is an inhibitor of notch signaling that targets notch for ubiquitin-mediated protein degradation". Mol. Cell. Biol. 21 (21): 7403–15. doi:10.1128/MCB.21.21.7403-7415.2001. PMC 99913. PMID 11585921.
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