KCNC4
| KCNC4 | |||||||||||||||||||||||||||||||||||||||||||||||||||
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| معینکنندهها | |||||||||||||||||||||||||||||||||||||||||||||||||||
| نامهای دیگر | KCNC4, C1orf30, HKSHIIIC, KSHIIIC, KV3.4, potassium voltage-gated channel subfamily C member 4 | ||||||||||||||||||||||||||||||||||||||||||||||||||
| شناسههای بیرونی | OMIM: 176265; MGI: 96670; HomoloGene: 68427; GeneCards: KCNC4; OMA:KCNC4 - orthologs | ||||||||||||||||||||||||||||||||||||||||||||||||||
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مجرای پتاسیم دریچهدار وابسته به ولتاژ، زیر خانواده مربوط به شا، عضو ۴ (انگلیسی: Potassium voltage-gated channel, Shaw-related subfamily, member 4) یا به اختصار KCNC4 که با نام Kv3.4 هم شناخته میشود یک پروتئین است که در انسان توسط ژن «KCNC4» کُدگذاری میشود.[۵]
این پروتئین به خانوادهٔ مجراهای پروتئینی یکسوکنندهٔ آهسته تعلق دارد که کارش میانجیگری و تنظیم نفوذپذیریِ وابسته به ولتاژِ یون پتاسیم است. تاکنون چندین گونهٔ رونویسی متفاوت ژنتیکی از این ژن کشف شدهاست.[۵]
منابع
- ↑ ۱٫۰ ۱٫۱ ۱٫۲ GRCh38: Ensembl release 89: ENSG00000116396 – Ensembl, May 2017
- ↑ ۲٫۰ ۲٫۱ ۲٫۲ GRCm38: Ensembl release 89: ENSMUSG00000027895 – Ensembl, May 2017
- ↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ↑ ۵٫۰ ۵٫۱ "Entrez Gene: KCNC4 potassium voltage-gated channel, Shaw-related subfamily, member 4".
- مشارکتکنندگان ویکیپدیا. «KCNC4». در دانشنامهٔ ویکیپدیای انگلیسی، بازبینیشده در ۶ اکتبر ۲۰۲۱.
برای مطالعهٔ بیشتر
- Gutman GA, Chandy KG, Grissmer S, et al. (2006). "International Union of Pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels". Pharmacol. Rev. 57 (4): 473–508. doi:10.1124/pr.57.4.10. PMID 16382104. S2CID 219195192.
- Vega-Saenz de Miera E, Moreno H, Fruhling D, et al. (1992). "Cloning of ShIII (Shaw-like) cDNAs encoding a novel high-voltage-activating, TEA-sensitive, type-A K+ channel". Proc. Biol. Sci. 248 (1321): 9–18. Bibcode:1992RSPSB.248....9V. doi:10.1098/rspb.1992.0036. PMID 1381835. S2CID 8968480.
- Ghanshani S, Pak M, McPherson JD, et al. (1992). "Genomic organization, nucleotide sequence, and cellular distribution of a Shaw-related potassium channel gene, Kv3.3, and mapping of Kv3.3 and Kv3.4 to human chromosomes 19 and 1". Genomics. 12 (2): 190–6. doi:10.1016/0888-7543(92)90365-Y. PMID 1740329.
- Rudy B, Sen K, Vega-Saenz de Miera E, et al. (1991). "Cloning of a human cDNA expressing a high voltage-activating, TEA-sensitive, type-A K+ channel which maps to chromosome 1 band p21". J. Neurosci. Res. 29 (3): 401–12. doi:10.1002/jnr.490290316. PMID 1920536. S2CID 27662306.
- Covarrubias M, Wei A, Salkoff L, Vyas TB (1995). "Elimination of rapid potassium channel inactivation by phosphorylation of the inactivation gate". Neuron. 13 (6): 1403–12. doi:10.1016/0896-6273(94)90425-1. PMC 2211371. PMID 7993631.
- Beck EJ, Sorensen RG, Slater SJ, Covarrubias M (1998). "Interactions between multiple phosphorylation sites in the inactivation particle of a K+ channel. Insights into the molecular mechanism of protein kinase C action". J. Gen. Physiol. 112 (1): 71–84. doi:10.1085/jgp.112.1.71. PMC 2229409. PMID 9649584.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Angulo E, Noé V, Casadó V, et al. (2005). "Up-regulation of the Kv3.4 potassium channel subunit in early stages of Alzheimer's disease". J. Neurochem. 91 (3): 547–57. doi:10.1111/j.1471-4159.2004.02771.x. PMID 15485486.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Abbott GW, Butler MH, Goldstein SA (2006). "Phosphorylation and protonation of neighboring MiRP2 sites: function and pathophysiology of MiRP2-Kv3.4 potassium channels in periodic paralysis" (PDF). FASEB J. 20 (2): 293–301. doi:10.1096/fj.05-5070com. PMID 16449802. S2CID 21538479.
{{cite journal}}: نگهداری یادکرد:doi رایگان بینشان (رده) - Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. Bibcode:2006Natur.441..315G. doi:10.1038/nature04727. PMID 16710414.
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نگارخانه بانک داده پروتئین | |
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