HDAC8
هیستون دِاَستیلاز ۸ (انگلیسی: Histone deacetylase 8) یک پروتئین است که در انسان توسط ژن «HDAC8» کُدگذاری میشود.[۵][۶][۷]
این پروتئین نقش بسیار مهمی در تنظیم رونویسی ژنها، پیشرفتِ چرخهٔ سلولی و وقایع تکاملی سلول دارد.
اهمیت بالینی
هیستون دِاَستیلاز ۸ با برخی بیماریها از جمله لوسمی حاد مغز استخوان و همچنین در اسکلت سلولی اکتین در ماهیچههای صاف مرتبط است. آراناِیهای خاموشگری که هیستون دِاَستیلاز ۸ را هدف قرار میدهند، خواص ضد سرطانی دارند.[۸] مهار این آنزیم همچنین موجب القای آپوپتوز در «لنفومهای سلول تی» میگردد.[۹]
هیستون دِاَستیلاز ۸ در بیماریزایی نوروبلاستوما هم نقش دارد.[۱۰] در نتیجه پژوهشگران علاقهمندند تا مهارکنندههای انتخابی این آنزیم را بسازند.[۱۱][۱۲]
منابع
- ↑ ۱٫۰ ۱٫۱ ۱٫۲ GRCh38: Ensembl release 89: ENSG00000147099 – Ensembl, May 2017
- ↑ ۲٫۰ ۲٫۱ ۲٫۲ GRCm38: Ensembl release 89: ENSMUSG00000067567 – Ensembl, May 2017
- ↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ↑ McDonell N, Ramser J, Francis F, Vinet MC, Rider S, Sudbrak R, Riesselman L, Yaspo ML, Reinhardt R, Monaco AP, Ross F, Kahn A, Kearney L, Buckle V, Chelly J (May 2000). "Characterization of a highly complex region in Xq13 and mapping of three isodicentric breakpoints associated with preleukemia". Genomics. 64 (3): 221–9. doi:10.1006/geno.2000.6128. PMID 10756090.
- ↑ Van den Wyngaert I, de Vries W, Kremer A, Neefs J, Verhasselt P, Luyten WH, Kass SU (Aug 2000). "Cloning and characterization of human histone deacetylase 8". FEBS Lett. 478 (1–2): 77–83. doi:10.1016/S0014-5793(00)01813-5. PMID 10922473.
- ↑ "Entrez Gene: HDAC8 histone deacetylase 8".
- ↑ Gallinari P, Di Marco S, Jones P, Pallaoro M, Steinkühler C (March 2007). "HDACs, histone deacetylation and gene transcription: from molecular biology to cancer therapeutics". Cell Res. 17 (3): 195–211. doi:10.1038/sj.cr.7310149. PMID 17325692.
- ↑ Balasubramanian S, Ramos J, Luo W, Sirisawad M, Verner E, Buggy JJ (May 2008). "A novel histone deacetylase 8 (HDAC8)-specific inhibitor PCI-34051 induces apoptosis in T-cell lymphomas". Leukemia. 22 (5): 1026–34. doi:10.1038/leu.2008.9. PMID 18256683.
- ↑ Oehme I, Deubzer HE, Wegener D, Pickert D, Linke JP, Hero B, Kopp-Schneider A, Westermann F, Ulrich SM, von Deimling A, Fischer M, Witt O (January 2009). "Histone deacetylase 8 in neuroblastoma tumorigenesis". Clin. Cancer Res. 15 (1): 91–9. doi:10.1158/1078-0432.CCR-08-0684. PMID 19118036.
- ↑ Patil V, Sodji QH, Kornacki JR, Mrksich M, Oyelere AK (May 2013). "3-Hydroxypyridin-2-thione as novel zinc binding group for selective histone deacetylase inhibition". Journal of Medicinal Chemistry. 56 (9): 3492–506. doi:10.1021/jm301769u. PMC 3657749. PMID 23547652.
- ↑ Suzuki T, Ota Y, Ri M, Bando M, Gotoh A, Itoh Y, Tsumoto H, Tatum PR, Mizukami T, Nakagawa H, Iida S, Ueda R, Shirahige K, Miyata N (November 2012). "Rapid discovery of highly potent and selective inhibitors of histone deacetylase 8 using click chemistry to generate candidate libraries". Journal of Medicinal Chemistry. 55 (22): 9562–75. doi:10.1021/jm300837y. PMID 23116147.
- مشارکتکنندگان ویکیپدیا. «HDAC8». در دانشنامهٔ ویکیپدیای انگلیسی، بازبینیشده در ۱۰ مارس ۲۰۲۰.
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- Glénisson W, Waltregny D, Tran SL, North BJ, Verdin E, Colige A, Castronovo V (June 2005). "Histone deacetylase HDAC8 associates with smooth muscle alpha-actin and is essential for smooth muscle cell contractility". FASEB J. 19 (8): 966–8. doi:10.1096/fj.04-2303fje. PMID 15772115.
{{cite journal}}: نگهداری یادکرد:doi رایگان بینشان (رده) - Wedel T, Van Eys GJ, Waltregny D, Glénisson W, Castronovo V, Vanderwinden JM (2006). "Novel smooth muscle markers reveal abnormalities of the intestinal musculature in severe colorectal motility disorders". Neurogastroenterol. Motil. 18 (7): 526–38. doi:10.1111/j.1365-2982.2006.00781.x. PMID 16771768.
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- Hu E, Chen Z, Fredrickson T, et al. (2000). "Cloning and characterization of a novel human class I histone deacetylase that functions as a transcription repressor". J. Biol. Chem. 275 (20): 15254–64. doi:10.1074/jbc.M908988199. PMID 10748112.
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- Durst KL, Lutterbach B, Kummalue T, et al. (2003). "The inv(16) fusion protein associates with corepressors via a smooth muscle myosin heavy-chain domain". Mol. Cell. Biol. 23 (2): 607–19. doi:10.1128/MCB.23.2.607-619.2003. PMC 151524. PMID 12509458.
- Rodriguez M, Yu X, Chen J, Songyang Z (2004). "Phosphopeptide binding specificities of BRCA1 COOH-terminal (BRCT) domains". J. Biol. Chem. 278 (52): 52914–8. doi:10.1074/jbc.C300407200. PMID 14578343.
{{cite journal}}: نگهداری یادکرد:doi رایگان بینشان (رده) - Johnson JM, Castle J, Garrett-Engele P, et al. (2004). "Genome-wide survey of human alternative pre-mRNA splicing with exon junction microarrays". Science. 302 (5653): 2141–4. CiteSeerX 10.1.1.1017.9438. doi:10.1126/science.1090100. PMID 14684825.
- Lee H, Rezai-Zadeh N, Seto E (2004). "Negative regulation of histone deacetylase 8 activity by cyclic AMP-dependent protein kinase A". Mol. Cell. Biol. 24 (2): 765–73. doi:10.1128/MCB.24.2.765-773.2004. PMC 343812. PMID 14701748.
- Vannini A, Volpari C, Filocamo G, et al. (2004). "Crystal structure of a eukaryotic zinc-dependent histone deacetylase, human HDAC8, complexed with a hydroxamic acid inhibitor". Proc. Natl. Acad. Sci. U.S.A. 101 (42): 15064–9. doi:10.1073/pnas.0404603101. PMC 524051. PMID 15477595.
- Waltregny D, North B, Van Mellaert F, et al. (2005). "Screening of histone deacetylases (HDAC) expression in human prostate cancer reveals distinct class I HDAC profiles between epithelial and stromal cells". European Journal of Histochemistry. 48 (3): 273–90. PMID 15590418.
- Waltregny D, Glénisson W, Tran SL, et al. (2006). "Histone deacetylase HDAC8 associates with smooth muscle alpha-actin and is essential for smooth muscle cell contractility". FASEB J. 19 (8): 966–8. doi:10.1096/fj.04-2303fje. PMID 15772115.
{{cite journal}}: نگهداری یادکرد:doi رایگان بینشان (رده) - Gantt SL, Gattis SG, Fierke CA (2006). "Catalytic activity and inhibition of human histone deacetylase 8 is dependent on the identity of the active site metal ion". Biochemistry. 45 (19): 6170–8. doi:10.1021/bi060212u. PMID 16681389.
- Lee H, Sengupta N, Villagra A, et al. (2006). "Histone deacetylase 8 safeguards the human ever-shorter telomeres 1B (hEST1B) protein from ubiquitin-mediated degradation". Mol. Cell. Biol. 26 (14): 5259–69. doi:10.1128/MCB.01971-05. PMC 1592721. PMID 16809764.
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پیوند به بیرون
- HDAC8 protein, human در سرعنوانهای موضوعی پزشکی (MeSH) در کتابخانهٔ ملی پزشکی ایالات متحدهٔ آمریکا
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