HDAC4
هیستون دِاَستیلاز ۴ (انگلیسی: Histone deacetylase 4) یک پروتئین است که در انسان توسط ژن «HDAC4» کُدگذاری میشود.[۵][۶]
این پروتئین نقش بسیار مهمی در تنظیم رونویسی ژنها، پیشرفتِ چرخهٔ سلولی و وقایع تکاملی سلول دارد.
هیستون دِاَستیلاز ۹، با مولکول HDAC3[۵][۷][۸][۹] و ZBTB16[۱۰][۱۱] تعامل پروتئین-پروتئین دارد.
اهمیت بالینی
پژوهشها نشان دادهاند که هیستون دِاَستیلاز ۴ در رشد و تکامل استخوان و ماهیچه نقش دارد.
همچنین پژوهشگران دانشگاه هاروارد به این نتیجه رسیدهاند که این آنزیم در سلامت قوهٔ بینایی نقش دارد: کاهش سطح این آنزیم موجب مرگ گیرندههای استوانهایشکل و سلولهای دوقطبی شبکیه در موشها میگردد.[۱۲][۱۳]
منابع
- ↑ ۱٫۰ ۱٫۱ ۱٫۲ GRCh38: Ensembl release 89: ENSG00000068024 – Ensembl, May 2017
- ↑ ۲٫۰ ۲٫۱ ۲٫۲ GRCm38: Ensembl release 89: ENSMUSG00000026313 – Ensembl, May 2017
- ↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ↑ ۵٫۰ ۵٫۱ Grozinger CM, Hassig CA, Schreiber SL (April 1999). "Three proteins define a class of human histone deacetylases related to yeast Hda1p". Proceedings of the National Academy of Sciences of the United States of America. 96 (9): 4868–73. doi:10.1073/pnas.96.9.4868. PMC 21783. PMID 10220385.
- ↑ Fischle W, Emiliani S, Hendzel MJ, Nagase T, Nomura N, Voelter W, Verdin E (April 1999). "A new family of human histone deacetylases related to Saccharomyces cerevisiae HDA1p". The Journal of Biological Chemistry. 274 (17): 11713–20. doi:10.1074/jbc.274.17.11713. PMID 10206986.
{{cite journal}}: نگهداری یادکرد:doi رایگان بینشان (رده) - ↑ Fischle W, Dequiedt F, Hendzel MJ, Guenther MG, Lazar MA, Voelter W, Verdin E (January 2002). "Enzymatic activity associated with class II HDACs is dependent on a multiprotein complex containing HDAC3 and SMRT/N-CoR". Molecular Cell. 9 (1): 45–57. doi:10.1016/s1097-2765(01)00429-4. PMID 11804585.
- ↑ Grozinger CM, Schreiber SL (July 2000). "Regulation of histone deacetylase 4 and 5 and transcriptional activity by 14-3-3-dependent cellular localization". Proceedings of the National Academy of Sciences of the United States of America. 97 (14): 7835–40. doi:10.1073/pnas.140199597. PMC 16631. PMID 10869435.
- ↑ Fischle W, Dequiedt F, Fillion M, Hendzel MJ, Voelter W, Verdin E (September 2001). "Human HDAC7 histone deacetylase activity is associated with HDAC3 in vivo". The Journal of Biological Chemistry. 276 (38): 35826–35. doi:10.1074/jbc.M104935200. PMID 11466315.
{{cite journal}}: نگهداری یادکرد:doi رایگان بینشان (رده) - ↑ Lemercier C, Brocard MP, Puvion-Dutilleul F, Kao HY, Albagli O, Khochbin S (June 2002). "Class II histone deacetylases are directly recruited by BCL6 transcriptional repressor". The Journal of Biological Chemistry. 277 (24): 22045–52. doi:10.1074/jbc.M201736200. PMID 11929873.
{{cite journal}}: نگهداری یادکرد:doi رایگان بینشان (رده) - ↑ Chauchereau A, Mathieu M, de Saintignon J, Ferreira R, Pritchard LL, Mishal Z, Dejean A, Harel-Bellan A (November 2004). "HDAC4 mediates transcriptional repression by the acute promyelocytic leukaemia-associated protein PLZF". Oncogene. 23 (54): 8777–84. doi:10.1038/sj.onc.1208128. PMID 15467736.
- ↑ Protein for Sight, Scientific American, 300, 3 (March 2009), p. 23
- ↑ Chen B, Cepko CL (January 2009). "HDAC4 regulates neuronal survival in normal and diseased retinas". Science. 323 (5911): 256–9. doi:10.1126/science.1166226. PMC 3339762. PMID 19131628.
- مشارکتکنندگان ویکیپدیا. «HDAC4». در دانشنامهٔ ویکیپدیای انگلیسی، بازبینیشده در ۱۰ مارس ۲۰۲۰.
برای مطالعهٔ بیشتر
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{{cite journal}}: نگهداری یادکرد:doi رایگان بینشان (رده) - Grozinger CM, Hassig CA, Schreiber SL (April 1999). "Three proteins define a class of human histone deacetylases related to yeast Hda1p". Proceedings of the National Academy of Sciences of the United States of America. 96 (9): 4868–73. doi:10.1073/pnas.96.9.4868. PMC 21783. PMID 10220385.
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- Huynh KD, Fischle W, Verdin E, Bardwell VJ (July 2000). "BCoR, a novel corepressor involved in BCL-6 repression". Genes & Development. 14 (14): 1810–23. doi:10.1101/gad.14.14.1810 (inactive 2019-12-14). PMC 316791. PMID 10898795.
{{cite journal}}: نگهداری یادکرد:doi غیرفعال از دسامبر 2019 (رده) - Li J, Wang J, Wang J, Nawaz Z, Liu JM, Qin J, Wong J (August 2000). "Both corepressor proteins SMRT and N-CoR exist in large protein complexes containing HDAC3". The EMBO Journal. 19 (16): 4342–50. doi:10.1093/emboj/19.16.4342. PMC 302030. PMID 10944117.
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{{cite journal}}: نگهداری یادکرد:doi رایگان بینشان (رده) - McKinsey TA, Zhang CL, Lu J, Olson EN (November 2000). "Signal-dependent nuclear export of a histone deacetylase regulates muscle differentiation". Nature. 408 (6808): 106–11. doi:10.1038/35040593. PMC 4459600. PMID 11081517.
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نگارخانه بانک داده پروتئین | |
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