گیرندهٔ شمارهٔ ۱۳۳ جفتشونده با پروتئین جی (انگلیسی: G protein-coupled receptor 133) یک پروتئین است که در انسان توسط ژن «GPR133» کُدگذاری میشود.[۵][۶]
این گیرنده یکی از اعضای خانوادهٔ بزرگ «گیرندههای جفتشونده با پروتئین جی، ویژهٔ چسبندگی» است.
آگونیستهای این گیرنده مانند جیال-۶۴ و ایپی-۵۰۳ کاربردهای بالقوهای در درمان پوکی استخوان دارند.[۷][۸]
↑Fredriksson R, Lagerstrom MC, Hoglund PJ, Schioth HB (Nov 2002). "Novel human G protein-coupled receptors with long N-terminals containing GPS domains and Ser/Thr-rich regions". FEBS Lett. 531 (3): 407–14. doi:10.1016/S0014-5793(02)03574-3. PMID12435584.
↑He L, Zhang Q, You Y, Sun P, Xu Z, Li R, Wang F, Zhang S, He J, Shen J, Zhao L, Hong Y, Li Y, Liu M, Sun JP, Wang N, Sun Y, Yang H, Luo J. Exogenous activation of the adhesion GPCR ADGRD1/GPR133 protects against bone loss by negatively regulating osteoclastogenesis. Sci Adv. 2025 Jul 11;11(28):eads3829. doi:10.1126/sciadv.ads3829PMID40644539
↑Lehmann J, Lin H, Zhang Z, Wiermann M, Ricken AM, Brinkmann F, Brendler J, Ullmann C, Bayer L, Berndt S, Penk A, Winkler N, Hirsch FW, Fuhs T, Käs J, Xiao P, Schöneberg T, Rauner M, Sun JP, Liebscher I. The mechanosensitive adhesion G protein-coupled receptor 133 (GPR133/ADGRD1) enhances bone formation. Signal Transduct Target Ther. 2025 Jun 30;10(1):199. doi: 10.1038/s41392-025-02291-yPMID40583059
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID14702039.
Bjarnadóttir TK, Fredriksson R, Höglund PJ, et al. (2005). "The human and mouse repertoire of the adhesion family of G-protein-coupled receptors". Genomics. 84 (1): 23–33. doi:10.1016/j.ygeno.2003.12.004. PMID15203201.
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