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GABRG2
معین‌کننده‌ها
نام‌های دیگر	GABRG2, CAE2, ECA2, GEFSP3, gamma-aminobutyric acid type A receptor gamma2 subunit, EIEE74, FEB8
شناسه‌های بیرونی	OMIM: 137164; MGI: 95623; HomoloGene: 22443; GeneCards: GABRG2; OMA:GABRG2 - orthologs
موقعیت ژن (انسان)
کروموزوم	کروموزوم ۵ (انسان)
پایان	162,162,977 bp
موقعیت ژن (موش)
کروموزوم	کروموزوم ۱۱ (موش)
پایان	41,891,684 bp
الگوی گسترش RNA
	بیشترین بیان در
	middle temporal gyrus; ; Brodmann area 23; ; superior frontal gyrus; ; primary visual cortex; ; postcentral gyrus; ; frontal pole; ; endothelial cell;
	بیشترین بیان در
	primary visual cortex; ; superior frontal gyrus; ; perirhinal cortex; ; central gray substance of midbrain; ; dentate gyrus of hippocampal formation granule cell; ; cerebellar cortex; ; lateral hypothalamus;
	داده‌های بیشتر بیان
	داده‌های بیشتر بیان
هستی‌شناسی ژن
عملکرد ملکولی	پیوند پروتئینی; benzodiazepine receptor activity; extracellular ligand-gated ion channel activity; chloride channel activity; GABA-A receptor activity; ion channel activity; transmembrane signaling receptor activity; inhibitory extracellular ligand-gated ion channel activity; GABA-gated chloride ion channel activity; transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential;
ترکیبات سلولی	integral component of membrane; postsynaptic membrane; membrane; سیناپس; dendrite membrane; chloride channel complex; آسه; پیوند میان‌یاخته‌ای; integral component of plasma membrane; پوسته یاخته; دندریت; cytoplasmic vesicle membrane; cytoplasmic vesicle; cell projection; GABA-A receptor complex; neuron projection; postsynapse; GABA-ergic synapse;
فرایند زیستی	gamma-aminobutyric acid signaling pathway; synaptic transmission, GABAergic; ion transport; post-embryonic development; adult behavior; chloride transport; cellular response to histamine; chemical synaptic transmission; chloride transmembrane transport; ion transmembrane transport; ورارسانی پیام; regulation of membrane potential; nervous system process; regulation of postsynaptic membrane potential; inhibitory synapse assembly;
	منابع: آمیگو / کوئیک‌گو
هم‌ساخت‌شناسی
	2566
	14406
	ENSG00000113327
	ENSMUSG00000020436
	P18507
	P22723
	NM_198904; NM_000816; NM_198903
	NM_008073; NM_177408; NM_001362655; NM_001362656
NP_000807; NP_944493; NP_944494; NP_001362268; NP_001362269;
	NP_001362270; NP_001362271; NP_001362272; NP_001362273; NP_001362274; NP_001362275; NP_001362276; NP_001362277; NP_001362278; NP_001362279
	NP_032099; NP_803127; NP_001349584; NP_001349585
	ویکی‌داده
مشاهده/ویرایش انسان	مشاهده/ویرایش موش

زیرواحد گاما-۲ گیرندهٔ گاما-آمینوبوتیریک اسید (انگلیسی: Gamma-aminobutyric acid receptor subunit gamma-2) یک پروتئین است که در انسان توسط ژن «GABRG2» کُدگذاری می‌شود.

این پروتئین با مولکول‌های GABARAP^[۵]^[۶]^[۷] و گیرنده دی۵ دوپامین^[۸] تعامل پروتئین-پروتئین دارد.

جستارهای وابسته

گیرنده گابا A

منابع

↑ ^۱٫۰ ^۱٫۱ ^۱٫۲ GRCh38: Ensembl release 89: ENSG00000113327 – Ensembl, May 2017
↑ ^۲٫۰ ^۲٫۱ ^۲٫۲ GRCm38: Ensembl release 89: ENSMUSG00000020436 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Nymann-Andersen J, Wang H, Chen L, Kittler JT, Moss SJ, Olsen RW (March 2002). "Subunit specificity and interaction domain between GABA(A) receptor-associated protein (GABARAP) and GABA(A) receptors". Journal of Neurochemistry. 80 (5): 815–823. doi:10.1046/j.0022-3042.2002.00762.x. PMID 11948245. S2CID 38049055.
↑ Coyle JE, Qamar S, Rajashankar KR, Nikolov DB (January 2002). "Structure of GABARAP in two conformations: implications for GABA(A) receptor localization and tubulin binding". Neuron. 33 (1): 63–74. doi:10.1016/S0896-6273(01)00558-X. PMID 11779480. S2CID 14487823.
↑ Wang H, Bedford FK, Brandon NJ, Moss SJ, Olsen RW (January 1999). "GABA(A)-receptor-associated protein links GABA(A) receptors and the cytoskeleton". Nature. 397 (6714): 69–72. doi:10.1038/16264. PMID 9892355. S2CID 204990449.
↑ Liu F, Wan Q, Pristupa ZB, Yu XM, Wang YT, Niznik HB (January 2000). "Direct protein-protein coupling enables cross-talk between dopamine D5 and gamma-aminobutyric acid A receptors". Nature. 403 (6767): 274–280. Bibcode:2000Natur.403..274L. doi:10.1038/35002014. PMID 10659839. S2CID 4415918.

مشارکت‌کنندگان ویکی‌پدیا. «Gamma-aminobutyric acid receptor subunit gamma-2». در دانشنامهٔ ویکی‌پدیای انگلیسی، بازبینی‌شده در ۱۴ اکتبر ۲۰۲۲.

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Bonnert TP, McKernan RM, Farrar S, le Bourdellès B, Heavens RP, Smith DW, Hewson L, Rigby MR, Sirinathsinghji DJ, Brown N, Wafford KA, Whiting PJ (August 1999). "theta, a novel gamma-aminobutyric acid type A receptor subunit". Proceedings of the National Academy of Sciences of the United States of America. 96 (17): 9891–9896. Bibcode:1999PNAS...96.9891B. doi:10.1073/pnas.96.17.9891. PMC 22306. PMID 10449790.
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Baulac S, Huberfeld G, Gourfinkel-An I, Mitropoulou G, Beranger A, Prud'homme JF, Baulac M, Brice A, Bruzzone R, LeGuern E (May 2001). "First genetic evidence of GABA(A) receptor dysfunction in epilepsy: a mutation in the gamma2-subunit gene". Nature Genetics. 28 (1): 46–48. doi:10.1038/88254. PMID 11326274.
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Jiang S, Yu J, Wang J, Tan Z, Xue H, Feng G, He L, Yang H (2001). "Complete genomic sequence of 195 Kb of human DNA containing the gene GABRG2". DNA Sequence. 11 (5): 373–382. doi:10.3109/10425170009033988. PMID 11328646. S2CID 43206605.
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این یک مقالهٔ خرد زیست‌شناسی مولکولی است. می‌توانید با گسترش آن به ویکی‌پدیا کمک کنید.

[refGRCh38Ensembl-1] ۱٫۰ ^۱٫۱ ^۱٫۲ GRCh38: Ensembl release 89: ENSG00000113327 – Ensembl, May 2017

[refGRCm38Ensembl-2] ۲٫۰ ^۲٫۱ ^۲٫۲ GRCm38: Ensembl release 89: ENSMUSG00000020436 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11948245-5] Nymann-Andersen J, Wang H, Chen L, Kittler JT, Moss SJ, Olsen RW (March 2002). "Subunit specificity and interaction domain between GABA(A) receptor-associated protein (GABARAP) and GABA(A) receptors". Journal of Neurochemistry. 80 (5): 815–823. doi:10.1046/j.0022-3042.2002.00762.x. PMID 11948245. S2CID 38049055.

[pmid11779480-6] Coyle JE, Qamar S, Rajashankar KR, Nikolov DB (January 2002). "Structure of GABARAP in two conformations: implications for GABA(A) receptor localization and tubulin binding". Neuron. 33 (1): 63–74. doi:10.1016/S0896-6273(01)00558-X. PMID 11779480. S2CID 14487823.

[pmid9892355-7] Wang H, Bedford FK, Brandon NJ, Moss SJ, Olsen RW (January 1999). "GABA(A)-receptor-associated protein links GABA(A) receptors and the cytoskeleton". Nature. 397 (6714): 69–72. doi:10.1038/16264. PMID 9892355. S2CID 204990449.

[pmid10659839-8] Liu F, Wan Q, Pristupa ZB, Yu XM, Wang YT, Niznik HB (January 2000). "Direct protein-protein coupling enables cross-talk between dopamine D5 and gamma-aminobutyric acid A receptors". Nature. 403 (6767): 274–280. Bibcode:2000Natur.403..274L. doi:10.1038/35002014. PMID 10659839. S2CID 4415918.

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GABRG2

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