G6PC
گلوکز-۶-فسفاتاز، زیرواحد کاتالیتیک (انگلیسی: Glucose-6-phosphatase, catalytic subunit) یک آنزیم است که در انسان توسط ژن «G6PC» کُدگذاری میشود.[۵][۶]
این آنزیم یک پروتئین پوستهای در شبکه آندوپلاسمی است که موجب هیدرولیز «دی-گلوکز-۶-فسفات» به دو مادهٔ «دی-گلوکز» و «اورتوفسفات» میگردد و یک آنزیم بسیار مهم در هوموستاز گلوکز طی فرایندهای گلوکونئوژنز و گلیکوژنولیز محسوب میشود.
اهمیت بالینی
نقص در این آنزیم سبب بروز گلیکوژنوز نوع یک (بیماری فون ژیرکه) میگردد.[۶]
جستارهای وابسته
منابع
- ↑ ۱٫۰ ۱٫۱ ۱٫۲ GRCh38: Ensembl release 89: ENSG00000131482 – Ensembl, May 2017
- ↑ ۲٫۰ ۲٫۱ ۲٫۲ GRCm38: Ensembl release 89: ENSMUSG00000078650 – Ensembl, May 2017
- ↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ↑ Brody LC, Abel KJ, Castilla LH, Couch FJ, McKinley DR, Yin G, Ho PP, Merajver S, Chandrasekharappa SC, Xu J, et al. (Jul 1995). "Construction of a transcription map surrounding the BRCA1 locus of human chromosome 17". Genomics. 25 (1): 238–47. doi:10.1016/0888-7543(95)80131-5. PMID 7774924.
- ↑ ۶٫۰ ۶٫۱ "Entrez Gene: G6PC glucose-6-phosphatase, catalytic subunit".
- مشارکتکنندگان ویکیپدیا. «G6PC». در دانشنامهٔ ویکیپدیای انگلیسی، بازبینیشده در ۲ نوامبر ۲۰۱۸.
بیشتر بخوانید
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- Pan CJ, Lei KJ, Chou JY (1998). "Asparagine-linked oligosaccharides are localized to a luminal hydrophilic loop in human glucose-6-phosphatase". J. Biol. Chem. 273 (34): 21658–62. doi:10.1074/jbc.273.34.21658. PMID 9705299.
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