FOXA1
پروتئین A1 جعبه سرچنگالی (به انگلیسی: Forkhead box protein A1) یا به اختصار FOXA1 که با نام فاکتور ۳-آلفا هستهای هپاتوسیت (HNF-3A) هم شناخته میشود، یک پروتئین است که در انسان توسط ژن «FOXA1» کُدگذاری میشود.[۵][۶][۷]
عملکرد
این پروتئین یکی از اعضای خانوادهٔ پروتئینهای FOX است که به دیانای متصل میشوند و فعالکنندههای رونویسی مولکولهای خاص کبدی همچون آلبومین و ترانستیرتین هستند و با کروماتین نیز واکنش نشان میدهند. این پروتئین همچنین یک نشانگر زیستی در سرطان پستان است.
اهمیت بالینی
جهش در ژن «FOXA1» سرطان پروستات مشاهده شدهاست.[۸] میزان بیانِ این ژن همچنین با دو نشانگر زیستی دیگر در سرطان پستان (یعنی ئی-کادهرین و TWIST1) مطابقت دارد.[۹]
منابع
- ↑ ۱٫۰ ۱٫۱ ۱٫۲ GRCh38: Ensembl release 89: ENSG00000129514 – Ensembl, May 2017
- ↑ ۲٫۰ ۲٫۱ ۲٫۲ GRCm38: Ensembl release 89: ENSMUSG00000035451 – Ensembl, May 2017
- ↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ↑ "Entrez Gene: forkhead box A1".
- ↑ Bingle CD, Gowan S (1996). "Molecular cloning of the forkhead transcription factor HNF-3 alpha from a human pulmonary adenocarcinoma cell line". Biochim Biophys Acta. 1307 (1): 17–20. doi:10.1016/0167-4781(96)00058-9. PMID 8652662.
- ↑ Mincheva A, Lichter P, Schütz G, Kaestner KH (1997). "Assignment of the human genes for hepatocyte nuclear factor 3-alpha, -beta, and -gamma (HNF3A, HNF3B, HNF3G) to 14q12-q13, 20p11, and 19q13.2-q13.4". Genomics. 39 (3): 417–9. doi:10.1006/geno.1996.4477. PMID 9119385.
- ↑ Barbieri CE, Baca SC, Lawrence MS, Demichelis F, Blattner M, Theurillat JP, White TA, Stojanov P, Van Allen E, Stransky N, Nickerson E, Chae SS, Boysen G, Auclair D, Onofrio RC, Park K, Kitabayashi N, MacDonald TY, Sheikh K, Vuong T, Guiducci C, Cibulskis K, Sivachenko A, Carter SL, Saksena G, Voet D, Hussain WM, Ramos AH, Winckler W, Redman MC, Ardlie K, Tewari AK, Mosquera JM, Rupp N, Wild PJ, Moch H, Morrissey C, Nelson PS, Kantoff PW, Gabriel SB, Golub TR, Meyerson M, Lander ES, Getz G, Rubin MA, Garraway LA (June 2012). "Exome sequencing identifies recurrent SPOP, FOXA1 and MED12 mutations in prostate cancer". Nat. Genet. 44 (6): 685–9. doi:10.1038/ng.2279. PMC 3673022. PMID 22610119.
- ↑ BenAyed-Guerfali, Dorra; Dabbèche-Bouricha, Emna; Ayadi, Wajdi; Trifa, Fatma; Charfi, Slim; Khabir, Abdelmajid; Sellami-Boudawara, Tahia; Mokdad-Gargouri, Raja (2019). "Association of FOXA1 and EMT markers (Twist1 and E-cadherin) in breast cancer". Molecular Biology Reports (in English). 46 (3): 3247–3255. doi:10.1007/s11033-019-04784-w. ISSN 0301-4851. PMID 30941644.
- مشارکتکنندگان ویکیپدیا. «FOXA1». در دانشنامهٔ ویکیپدیای انگلیسی.
برای مطالعهٔ بیشتر
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{{cite journal}}: نگهداری یادکرد:doi رایگان بینشان (رده) - Kohler S, Cirillo LA (2010). "Stable chromatin binding prevents FoxA acetylation, preserving FoxA chromatin remodeling". J. Biol. Chem. 285 (1): 464–72. doi:10.1074/jbc.M109.063149. PMC 2804194. PMID 19897491.
{{cite journal}}: نگهداری یادکرد:doi رایگان بینشان (رده) - Malik S, Jiang S, Garee JP, et al. (2010). "Histone deacetylase 7 and FoxA1 in estrogen-mediated repression of RPRM". Mol. Cell. Biol. 30 (2): 399–412. doi:10.1128/MCB.00907-09. PMC 2798473. PMID 19917725.
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{{cite journal}}: نگهداری یادکرد:doi رایگان بینشان (رده) - Eeckhoute J, Lupien M, Meyer CA, et al. (2009). "Cell-type selective chromatin remodeling defines the active subset of FOXA1-bound enhancers". Genome Res. 19 (3): 372–80. doi:10.1101/gr.084582.108. PMC 2661808. PMID 19129543.
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- Lee HJ, Chattopadhyay S, Yoon WH, et al. (2010). "Overexpression of hepatocyte nuclear factor-3alpha induces apoptosis through the upregulation and accumulation of cytoplasmic p53 in prostate cancer cells". Prostate. 70 (4): 353–61. doi:10.1002/pros.21069. PMID 19866472.
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{{cite journal}}: نگهداری یادکرد:doi رایگان بینشان (رده) - Huang QY, Li GH, Kung AW (2009). "The -9247 T/C polymorphism in the SOST upstream regulatory region that potentially affects C/EBPalpha and FOXA1 binding is associated with osteoporosis". Bone. 45 (2): 289–94. doi:10.1016/j.bone.2009.03.676. PMID 19371798.
- Sano M, Aoyagi K, Takahashi H, et al. (2010). "Forkhead box A1 transcriptional pathway in KRT7-expressing esophageal squamous cell carcinomas with extensive lymph node metastasis". Int. J. Oncol. 36 (2): 321–30. doi:10.3892/ijo_00000503. PMID 20043065.
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