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DNAJB4
معین‌کننده‌ها
نام‌های دیگر	DNAJB4, DNAJW, DjB4, HLJ1, DnaJ heat shock protein family (Hsp40) member B4
شناسه‌های بیرونی	OMIM: 611327; MGI: 1914285; HomoloGene: 100610; GeneCards: DNAJB4; OMA:DNAJB4 - orthologs
موقعیت ژن (انسان)
کروموزوم	کروموزوم ۱ (انسان)
پایان	78,017,964 bp
موقعیت ژن (موش)
کروموزوم	کروموزوم ۳ (موش)
پایان	151,915,939 bp
الگوی گسترش RNA
	بیشترین بیان در
	Skeletal muscle tissue of rectus abdominis; ; Skeletal muscle tissue of biceps brachii; ; muscle of thigh; ; tail of epididymis;
	بیشترین بیان در
	secondary oocyte; ; primary oocyte; ; atrioventricular valve; ; spermatid; ; tunica media of zone of aorta;
	داده‌های بیشتر بیان
	; ;
	داده‌های بیشتر بیان
هستی‌شناسی ژن
عملکرد ملکولی	unfolded protein binding; chaperone binding; پیوند پروتئینی; ATPase activator activity;
ترکیبات سلولی	سیتوزول; membrane; سیتوپلاسم; نوکلئوپلاسم; پوسته یاخته;
فرایند زیستی	response to unfolded protein; response to heat; تاشدگی پروتئین; positive regulation of ATP-dependent activity; negative regulation of transcription by RNA polymerase II; chaperone cofactor-dependent protein refolding;
	منابع: آمیگو / کوئیک‌گو
هم‌ساخت‌شناسی
	11080
	67035
	ENSG00000162616
	ENSMUSG00000028035
	Q9UDY4
	Q9D832
NM_007034; NM_001317099; NM_001317100; NM_001317101; NM_001317102;
	NM_001317103
	NM_025926; NM_027287; NM_001356363; NM_001356364
NP_001304028; NP_001304029; NP_001304030; NP_001304031; NP_001304032;
	NP_008965
	NP_080202; NP_081563; NP_001343292; NP_001343293
	ویکی‌داده
مشاهده/ویرایش انسان	مشاهده/ویرایش موش

عضو ۴ زیرخانواده B همولوگ DnaJ پروتئینی است که در انسان توسط ژن DNAJB4 کدگذاری می‌شود.^[۵]^[۶]^[۷]

منابع

↑ ^۱٫۰ ^۱٫۱ ^۱٫۲ GRCh38: Ensembl release 89: ENSG00000162616 – Ensembl, May 2017
↑ ^۲٫۰ ^۲٫۱ ^۲٫۲ GRCm38: Ensembl release 89: ENSMUSG00000028035 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Hoe KL, Won M, Chung KS, Jang YJ, Lee SB, Kim DU, Lee JW, Yun JH, Yoo HS (Apr 1998). "Isolation of a new member of DnaJ-like heat shock protein 40 (Hsp40) from human liver". Biochim Biophys Acta. 1383 (1): 4–8. doi:10.1016/s0167-4838(97)00207-0. PMID 9546042.
↑ Ohtsuka K, Hata M (Jan 2001). "Mammalian HSP40/DNAJ homologs: cloning of novel cDNAs and a proposal for their classification and nomenclature". Cell Stress Chaperones. 5 (2): 98–112. ISSN 1466-1268. PMC 312896. PMID 11147971.
↑ "Entrez Gene: DNAJB4 DnaJ (Hsp40) homolog, subfamily B, member 4".

جهت مطالعه

Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Rush J, Moritz A, Lee KA, et al. (2005). "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells". Nat. Biotechnol. 23 (1): 94–101. doi:10.1038/nbt1046. PMID 15592455. S2CID 7200157.
Borges JC, Fischer H, Craievich AF, Ramos CH (2005). "Low resolution structural study of two human HSP40 chaperones in solution. DJA1 from subfamily A and DJB4 from subfamily B have different quaternary structures". J. Biol. Chem. 280 (14): 13671–81. doi:10.1074/jbc.M408349200. PMID 15661747.
Wang CC, Tsai MF, Hong TM, et al. (2005). "The transcriptional factor YY1 upregulates the novel invasion suppressor HLJ1 expression and inhibits cancer cell invasion". Oncogene. 24 (25): 4081–93. doi:10.1038/sj.onc.1208573. PMID 15782117.
Ancevska-Taneva N, Onoprishvili I, Andria ML, et al. (2006). "A member of the heat shock protein 40 family, hlj1, binds to the carboxyl tail of the human mu opioid receptor". Brain Res. 1081 (1): 28–33. doi:10.1016/j.brainres.2006.01.125. PMID 16542645. S2CID 42100583.
Tsai MF, Wang CC, Chang GC, et al. (2006). "A new tumor suppressor DnaJ-like heat shock protein, HLJ1, and survival of patients with non-small-cell lung carcinoma". J. Natl. Cancer Inst. 98 (12): 825–38. doi:10.1093/jnci/djj229. PMID 16788156.

[refGRCh38Ensembl-1] ۱٫۰ ^۱٫۱ ^۱٫۲ GRCh38: Ensembl release 89: ENSG00000162616 – Ensembl, May 2017

[refGRCm38Ensembl-2] ۲٫۰ ^۲٫۱ ^۲٫۲ GRCm38: Ensembl release 89: ENSMUSG00000028035 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid_9546042-5] Hoe KL, Won M, Chung KS, Jang YJ, Lee SB, Kim DU, Lee JW, Yun JH, Yoo HS (Apr 1998). "Isolation of a new member of DnaJ-like heat shock protein 40 (Hsp40) from human liver". Biochim Biophys Acta. 1383 (1): 4–8. doi:10.1016/s0167-4838(97)00207-0. PMID 9546042.

[pmid_11147971-6] Ohtsuka K, Hata M (Jan 2001). "Mammalian HSP40/DNAJ homologs: cloning of novel cDNAs and a proposal for their classification and nomenclature". Cell Stress Chaperones. 5 (2): 98–112. ISSN 1466-1268. PMC 312896. PMID 11147971.

[entrez-7] "Entrez Gene: DNAJB4 DnaJ (Hsp40) homolog, subfamily B, member 4".

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DNAJB4

منابع

جهت مطالعه

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