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CCDC6
معین‌کننده‌ها
نام‌های دیگر	CCDC6, D10S170, H4, PTC, TPC, TST1, coiled-coil domain containing 6
شناسه‌های بیرونی	OMIM: 601985; MGI: 1923801; HomoloGene: 34786; GeneCards: CCDC6; OMA:CCDC6 - orthologs
موقعیت ژن (انسان)
کروموزوم	کروموزوم ۱۰ (انسان)
پایان	59,906,556 bp
موقعیت ژن (موش)
کروموزوم	کروموزوم ۱۰ (موش)
پایان	70,029,030 bp
الگوی گسترش RNA
	بیشترین بیان در
	secondary oocyte; ; buccal mucosa cell; ; skin of thigh; ; skin of hip; ; middle temporal gyrus; ; saphenous vein; ; parietal pleura; ; caput epididymis; ; jejunal mucosa;
	بیشترین بیان در
	secondary oocyte; ; primary oocyte; ; knee joint;
	داده‌های بیشتر بیان
	داده‌های بیشتر بیان
هستی‌شناسی ژن
عملکرد ملکولی	SH3 domain binding; structural constituent of cytoskeleton; پیوند پروتئینی;
ترکیبات سلولی	اسکلت سلولی; سیتوپلاسم; سیتوزول;
فرایند زیستی	cytoskeleton organization; فرایند زیست‌شناختی;
	منابع: آمیگو / کوئیک‌گو
هم‌ساخت‌شناسی
	8030
	76551
	ENSG00000108091
	ENSMUSG00000048701
	Q16204
	D3YZP9
	NM_005436
	NM_001111121
	NP_005427
	NP_001104591
	ویکی‌داده
مشاهده/ویرایش انسان	مشاهده/ویرایش موش

CCDC6(به انگلیسی: Coiled-coil domain-containing protein 6) پروتئینی است که در انسان توسط ژن CCDC6 کدگذاری می‌شود.^[۵]^[۶]^[۷]

فعل و انفعالات

مشخص شده‌است که CCDC6 با PPP4C تعامل پروتئین-پروتئین دارد.^[۸]^[۹]

منابع

↑ ^۱٫۰ ^۱٫۱ ^۱٫۲ GRCh38: Ensembl release 89: ENSG00000108091 – Ensembl, May 2017
↑ ^۲٫۰ ^۲٫۱ ^۲٫۲ GRCm38: Ensembl release 89: ENSMUSG00000048701 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Grieco M, Cerrato A, Santoro M, Fusco A, Melillo RM, Vecchio G (Sep 1994). "Cloning and characterization of H4 (D10S170), a gene involved in RET rearrangements in vivo". Oncogene. 9 (9): 2531–5. PMID 8058316.
↑ Anne-Spence M, Falk CT, Neiswanger K, Field LL, Marazita ML, Allen FH, Siervogel RM, Roche AF, Crandall BF, Sparkes RS (Sep 1984). "Estimating the recombination frequency for the PTC-Kell linkage". Human Genetics. 67 (2): 183–6. doi:10.1007/BF00272997. PMID 6745938.
↑ "Entrez Gene: CCDC6 coiled-coil domain containing 6".
↑ Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Molecular Systems Biology. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
↑ Chen GI, Tisayakorn S, Jorgensen C, D'Ambrosio LM, Goudreault M, Gingras AC (Oct 2008). "PP4R4/KIAA1622 forms a novel stable cytosolic complex with phosphoprotein phosphatase 4". The Journal of Biological Chemistry. 283 (43): 29273–84. doi:10.1074/jbc.M803443200. PMC 2662017. PMID 18715871.

پیوند به بیرون

مکان ژنوم CCDC6 انسانی و صفحهٔ جزئیات ژنی CCDC6 در سامانه جستجوی بانک ژنی دانشگاه کالیفرنیا، سانتا کروز.

جهت مطالعه

Sato O (Mar 1976). "[The dynamics of cerebrospinal fluid circulation (author's transl)]". No Shinkei Geka. Neurological Surgery. 4 (3): 211–7. PMID 775355.
Grieco M, Santoro M, Berlingieri MT, Melillo RM, Donghi R, Bongarzone I, Pierotti MA, Della Porta G, Fusco A, Vecchio G (Feb 1990). "PTC is a novel rearranged form of the ret proto-oncogene and is frequently detected in vivo in human thyroid papillary carcinomas". Cell. 60 (4): 557–63. doi:10.1016/0092-8674(90)90659-3. PMID 2406025. S2CID 22790995.
Tong Q, Li Y, Smanik PA, Fithian LJ, Xing S, Mazzaferri EL, Jhiang SM (May 1995). "Characterization of the promoter region and oligomerization domain of H4 (D10S170), a gene frequently rearranged with the ret proto-oncogene". Oncogene. 10 (9): 1781–7. PMID 7753554.
Hillier LD, Lennon G, Becker M, Bonaldo MF, Chiapelli B, Chissoe S, Dietrich N, DuBuque T, Favello A, Gish W, Hawkins M, Hultman M, Kucaba T, Lacy M, Le M, Le N, Mardis E, Moore B, Morris M, Parsons J, Prange C, Rifkin L, Rohlfing T, Schellenberg K, Bento Soares M, Tan F, Thierry-Meg J, Trevaskis E, Underwood K, Wohldman P, Waterston R, Wilson R, Marra M (Sep 1996). "Generation and analysis of 280,000 human expressed sequence tags". Genome Research. 6 (9): 807–28. doi:10.1101/gr.6.9.807. PMID 8889549.
Celetti A, Cerrato A, Merolla F, Vitagliano D, Vecchio G, Grieco M (Jan 2004). "H4(D10S170), a gene frequently rearranged with RET in papillary thyroid carcinomas: functional characterization". Oncogene. 23 (1): 109–21. doi:10.1038/sj.onc.1206981. PMID 14712216.
Brill LM, Salomon AR, Ficarro SB, Mukherji M, Stettler-Gill M, Peters EC (May 2004). "Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry". Analytical Chemistry. 76 (10): 2763–72. doi:10.1021/ac035352d. PMID 15144186.
Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP (Aug 2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proceedings of the National Academy of Sciences of the United States of America. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S (Jan 2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Research. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
Beausoleil SA, Villén J, Gerber SA, Rush J, Gygi SP (Oct 2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nature Biotechnology. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243. S2CID 14294292.
Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (Nov 2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Molecular Systems Biology. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
Merolla F, Pentimalli F, Pacelli R, Vecchio G, Fusco A, Grieco M, Celetti A (Sep 2007). "Involvement of H4(D10S170) protein in ATM-dependent response to DNA damage". Oncogene. 26 (42): 6167–75. doi:10.1038/sj.onc.1210446. PMID 17420723.

[refGRCh38Ensembl-1] ۱٫۰ ^۱٫۱ ^۱٫۲ GRCh38: Ensembl release 89: ENSG00000108091 – Ensembl, May 2017

[refGRCm38Ensembl-2] ۲٫۰ ^۲٫۱ ^۲٫۲ GRCm38: Ensembl release 89: ENSMUSG00000048701 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid_8058316-5] Grieco M, Cerrato A, Santoro M, Fusco A, Melillo RM, Vecchio G (Sep 1994). "Cloning and characterization of H4 (D10S170), a gene involved in RET rearrangements in vivo". Oncogene. 9 (9): 2531–5. PMID 8058316.

[pmid_6745938-6] Anne-Spence M, Falk CT, Neiswanger K, Field LL, Marazita ML, Allen FH, Siervogel RM, Roche AF, Crandall BF, Sparkes RS (Sep 1984). "Estimating the recombination frequency for the PTC-Kell linkage". Human Genetics. 67 (2): 183–6. doi:10.1007/BF00272997. PMID 6745938.

[entrez-7] "Entrez Gene: CCDC6 coiled-coil domain containing 6".

[pmid_17353931-8] Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Molecular Systems Biology. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.

[pmid_18715871-9] Chen GI, Tisayakorn S, Jorgensen C, D'Ambrosio LM, Goudreault M, Gingras AC (Oct 2008). "PP4R4/KIAA1622 forms a novel stable cytosolic complex with phosphoprotein phosphatase 4". The Journal of Biological Chemistry. 283 (43): 29273–84. doi:10.1074/jbc.M803443200. PMC 2662017. PMID 18715871.

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CCDC6

فعل و انفعالات

منابع

پیوند به بیرون

جهت مطالعه

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