BNIP3
پروتئین ۳ واکنشدهنده با پروتئین ۱۹ کیلو دالتونی E1B 19 آدنوویروس/E1B 19 (انگلیسی: BCL2/adenovirus E1B 19 kDa protein-interacting protein 3) یک پروتئین است که در انسان توسط ژن «BNIP3» کُدگذاری میشود.[۵]
این پروتئین عضوی از خانوادهٔ Bcl-2 است و در آپوپتوز نقش مهمی دارد و نفوذپذیری غشاء خارجی میتوکندری را با تشکیل هومو- و هترواولیگومرهایی در درون غشاء کنترل میکند.[۶] افزایش این پروتئین سبب کاهش پتانسیل الکتریکی میتوکندری، افزایش رادیکالهای آزاد اکسیژن، تورم و شکافتگی در میتوکندری و مرگ آنها از طریق خودخواری میگردد.[۷]
منابع
- ↑ ۱٫۰ ۱٫۱ ۱٫۲ GRCh38: Ensembl release 89: ENSG00000176171 – Ensembl, May 2017
- ↑ ۲٫۰ ۲٫۱ ۲٫۲ GRCm38: Ensembl release 89: ENSMUSG00000078566 – Ensembl, May 2017
- ↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ↑ Boyd JM, Malstrom S, Subramanian T, Venkatesh LK, Schaeper U, Elangovan B, et al. (October 1994). "Adenovirus E1B 19 kDa and Bcl-2 proteins interact with a common set of cellular proteins". Cell. 79 (2): 341–51. doi:10.1016/0092-8674(94)90202-X. PMID 7954800. S2CID 38609845.
- ↑ Sassone J, Colciago C, Marchi P, Ascardi C, Alberti L, Di Pardo A, et al. (January 2010). "Mutant Huntingtin induces activation of the Bcl-2/adenovirus E1B 19-kDa interacting protein (BNip3)". Cell Death & Disease. 1 (1): e7. doi:10.1038/cddis.2009.6. PMC 3032515. PMID 21364626.
- ↑ Liu KE, Frazier WA (2015-06-23). "Phosphorylation of the BNIP3 C-Terminus Inhibits Mitochondrial Damage and Cell Death without Blocking Autophagy". PLOS ONE. 10 (6): e0129667. Bibcode:2015PLoSO..1029667L. doi:10.1371/journal.pone.0129667. PMC 4477977. PMID 26102349.
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- مشارکتکنندگان ویکیپدیا. «BNIP3». در دانشنامهٔ ویکیپدیای انگلیسی، بازبینیشده در ۲۸ اکتبر ۲۰۲۰.
برای مطالعهٔ بیشتر
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- Shen XY, Zacal N, Singh G, Rainbow AJ (2005). "Alterations in mitochondrial and apoptosis-regulating gene expression in photodynamic therapy-resistant variants of HT29 colon carcinoma cells". Photochemistry and Photobiology. 81 (2): 306–13. doi:10.1562/2004-07-22-RA-242. PMID 15560738.
پیوند به بیرون
- مکان ژنوم BNIP3 انسانی و صفحهٔ جزئیات ژنی BNIP3 در سامانه جستجوی بانک ژنی دانشگاه کالیفرنیا، سانتا کروز.
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