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I suggest this article to be renamed Wobble HYPOTHESIS

Why the wobble hypothesis? I think the existence of these base pairs is pretty well established.

Also - the Wobble base pairs are not the primary means that nature uses 20 amino acids with 64 codons - most of this is just redundancy of codons (several codons that code for the same amino acid). The different codons can lead to different RNA folding, and also different folding of the nascent protein (because of differences during the translation process.) 142.157.72.172 18:31, 31 January 2007 (UTC) Jon[reply]

Resolved

The first references cited gives, for example, bovines as having 4112 tRNAs -- provided, vertebrates compose a tiny fraction of species, but to say that most species possess less than 45 species of tRNA while most vertebrates apparently have in the thousands...doesn't that sort of question whether or not the wobble effect takes place outside of microbiota? Or does it occurring there necessitate it occurring everywhere? DRosenbach ^{(Talk | Contribs)} 13:25, 4 August 2009 (UTC)[reply]

In the cited example the 4112 means that cows have 4112 'genes' for tRNA, not 4112 types of tRNA. There is considerable redundancy with many genes coding for each type of tRNA. Presumably there is evolutionary advantage in this - it means that a mutation in one of the genes that encodes tRNA will not be fatal. The cow exhibits both canonical and wobble pairing. For example Ala is enoded by GCU, GCC, GCA, GCG an the cow has genes for the four species of tRNA required by canonical pairing: _AGCtRNA^Ala (29 genes), _CGCtRNA^Ala (17 genes), _GGCtRNA^Ala (2 genes), _TGCtRNA^Ala (34 genes). However Asn ie encoded by AAU and AAC whereas the cow has only genes for _GTTtRNA^Asn - which means G-U and G-C wobble base pairing must be occurring in the encoding of Asn. Martin.Budden (talk) 20:22, 5 March 2010 (UTC)[reply]

The "wobble base" queuosine is not mentioned in this article, but should be included. I don't know if there are any others besides hypoxanthine and queuosine; can someone else chime in? MM (talk) 22:19, 18 May 2015 (UTC)[reply]

Does wobble base pairing hypothesis follows watson and cricks rule? 118.103.136.49 (talk) 06:25, 21 January 2022 (UTC)[reply]