This article is rated Start-class on Wikipedia's content assessment scale. It is of interest to the following WikiProjects:

Medicine: Genetics / Neurology Mid‑importance This article is within the scope of WikiProject Medicine, which recommends that medicine-related articles follow the Manual of Style for medicine-related articles and that biomedical information in any article use high-quality medical sources. Please visit the project page for details or ask questions at Wikipedia talk:WikiProject Medicine.MedicineWikipedia:WikiProject MedicineTemplate:WikiProject Medicinemedicine Mid This article has been rated as Mid-importance on the project's importance scale. This article is supported by the Medical genetics task force. This article is supported by the Neurology task force (assessed as Mid-importance).

Ideal sources for Wikipedia's health content are defined in the guideline Wikipedia:Identifying reliable sources (medicine) and are typically review articles. Here are links to possibly useful sources of information about Periodic paralysis. PubMed provides review articles from the past five years (limit to free review articles) The TRIP database provides clinical publications about evidence-based medicine. Other potential sources include: Centre for Reviews and Dissemination and CDC

I thought when I first came across the title that it was about the type of paralysis I have, which is brief and transient. But it turns out it's its own disease. Oh well. So how does hyperthyroidism lead to temporary paralysis? - Cyborg Ninja 10:26, 27 July 2007 (UTC)[reply]

Well, that depends on if you have thyrotoxicosis or TPP (thyrotoxic hypokalemic periodic paralysis). Extremity weakness often accompanies thyrotoxicosis, along with cardiac symptoms. In general, thyrotoxicosis leads to hypokalemia. This decrease in serum potassium prevents the Na+/K+-ATPase from properly maintaining ionic gradients and establishing the resting membrane potential (RMP). Thyroid hormones also modulate the levels of many ion channels. This along with aforementioned RMP alterations leads, presumably, to gradual depolarization to the point where voltage-gated channels can't recover from inactivation, at which point you're in a world of suckage. Hypokalemic periodic paralysis works in essentially the same way, though with and underlying channelopathy instead of concomitant thyrotoxicosis. If you want to know more about TPP you can contact me via email (from my user page). --Dpryan 19:42, 27 July 2007 (UTC)[reply]

Finally, somebody is acknowledging that potassium isn't a "cure". Why can't docs understand that it's a cellular distribution problem? I have Periodic Paralysis but did not improve from potassium therapy, and nothing else has been done thus far. I am now 30 years old and have permanent muscle weakness. I am taking this page to my doctor pronto. Thank you.

173.17.218.141 (talk) 09:09, 21 January 2009 (UTC)Kelli 1/21/09[reply]

Article has few sources, primarily by the same author(s). Only one section is sourced. More (and good, something I'm not qualified to identify) sources are needed. --Hordaland (talk) 07:30, 27 September 2015 (UTC)[reply]

Statland et al write about psychological symptoms like lack of energy but nothing about it here? Can someone include social effects? 2001:FB1:E3:E899:443B:83A1:A261:C4B1 (talk) 21:51, 20 October 2024 (UTC)[reply]

an the link: https://onlinelibrary.wiley.com/doi/10.1002/mus.26009 2001:FB1:E3:E899:443B:83A1:A261:C4B1 (talk) 21:51, 20 October 2024 (UTC)[reply]