TRAPPC3

TRAPPC3

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
1SZ7, 2C0J, 2CFH, 3KXC

Identifiers

TRAPPC3, BET3, trafficking protein particle complex 3, trafficking protein particle complex subunit 3

External IDs

OMIM: 610955; MGI: 1351486; HomoloGene: 6399; GeneCards: TRAPPC3; OMA:TRAPPC3 - orthologs

Gene location (Human)

Chr.	Chromosome 1 (human)^[1]

Band	1p34.3	Start	36,136,570 bp^[1]
Band	1p34.3	End	36,156,053 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 4 (mouse)^[2]

Band	4\|4 D2.2	Start	126,156,118 bp^[2]
Band	4\|4 D2.2	End	126,169,676 bp^[2]

RNA expression pattern

Human

Mouse (ortholog)

Top expressed in

right adrenal gland

right adrenal cortex

left adrenal gland

left adrenal cortex

right lobe of thyroid gland

islet of Langerhans

left lobe of thyroid gland

right coronary artery

muscle layer of sigmoid colon

left testis

Top expressed in

calvaria

neural layer of retina

medial ganglionic eminence

cerebellar cortex

dentate gyrus of hippocampal formation granule cell

right kidney

stroma of bone marrow

choroid plexus

lip

Epithelium of choroid plexus

More reference expression data


More reference expression data

Gene ontology
Molecular function	protein binding
Cellular component	Golgi apparatus endoplasmic reticulum Golgi membrane cytosol TRAPP complex cis-Golgi network membrane
Biological process	COPII vesicle coating vesicle-mediated transport Golgi vesicle transport endoplasmic reticulum to Golgi vesicle-mediated transport intra-Golgi vesicle-mediated transport
Sources:Amigo / QuickGO

Species

Human

Mouse


27095


27096


ENSG00000054116


ENSMUSG00000028847


O43617


O55013

RefSeq (mRNA)


NM_001270894 NM_001270895 NM_001270896 NM_001270897 NM_014408


NM_013718

RefSeq (protein)


NP_001257823 NP_001257824 NP_001257825 NP_001257826 NP_055223


NP_038746

Location (UCSC)

Chr 1: 36.14 – 36.16 Mb

Chr 4: 126.16 – 126.17 Mb

PubMed search

^[3]

^[4]

View/Edit Human

View/Edit Mouse

Trafficking protein particle complex subunit 3 is a protein that in humans is encoded by the TRAPPC3 gene.^[5]^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000054116 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000028847 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Andersson B, Wentland MA, Ricafrente JY, Liu W, Gibbs RA (Jun 1996). "A "double adaptor" method for improved shotgun library construction". Anal Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.
^ "Entrez Gene: TRAPPC3 trafficking protein particle complex 3".

Further reading

Yu W, Andersson B, Worley KC, et al. (1997). "Large-Scale Concatenation cDNA Sequencing". Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174.
Sacher M, Jiang Y, Barrowman J, et al. (1998). "TRAPP, a highly conserved novel complex on the cis-Golgi that mediates vesicle docking and fusion". EMBO J. 17 (9): 2494–503. doi:10.1093/emboj/17.9.2494. PMC 1170591. PMID 9564032.
Barrowman J, Sacher M, Ferro-Novick S (2000). "TRAPP stably associates with the Golgi and is required for vesicle docking". EMBO J. 19 (5): 862–9. doi:10.1093/emboj/19.5.862. PMC 305626. PMID 10698928.
Gavin AC, Bösche M, Krause R, et al. (2002). "Functional organization of the yeast proteome by systematic analysis of protein complexes". Nature. 415 (6868): 141–7. Bibcode:2002Natur.415..141G. doi:10.1038/415141a. PMID 11805826. S2CID 4425555.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Kim YG, Sohn EJ, Seo J, et al. (2005). "Crystal structure of bet3 reveals a novel mechanism for Golgi localization of tethering factor TRAPP". Nat. Struct. Mol. Biol. 12 (1): 38–45. doi:10.1038/nsmb871. PMID 15608655. S2CID 22597154.
Turnbull AP, Kümmel D, Prinz B, et al. (2005). "Structure of palmitoylated BET3: insights into TRAPP complex assembly and membrane localization". EMBO J. 24 (5): 875–84. doi:10.1038/sj.emboj.7600565. PMC 554119. PMID 15692564.
Loh E, Peter F, Subramaniam VN, Hong W (2005). "Mammalian Bet3 functions as a cytosolic factor participating in transport from the ER to the Golgi apparatus" (PDF). J. Cell Sci. 118 (Pt 6): 1209–22. doi:10.1242/jcs.01723. PMID 15728249. S2CID 3092909.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Kim MS, Yi MJ, Lee KH, et al. (2006). "Biochemical and crystallographic studies reveal a specific interaction between TRAPP subunits Trs33p and Bet3p". Traffic. 6 (12): 1183–95. doi:10.1111/j.1600-0854.2005.00352.x. PMID 16262728. S2CID 24273412.
Kümmel D, Müller JJ, Roske Y, et al. (2006). "Structure of the Bet3-Tpc6B core of TRAPP: two Tpc6 paralogs form trimeric complexes with Bet3 and Mum2". J. Mol. Biol. 361 (1): 22–32. doi:10.1016/j.jmb.2006.06.012. PMID 16828797.
Yu S, Satoh A, Pypaert M, et al. (2006). "mBet3p is required for homotypic COPII vesicle tethering in mammalian cells". J. Cell Biol. 174 (3): 359–68. doi:10.1083/jcb.200603044. PMC 2064232. PMID 16880271.
Kümmel D, Heinemann U, Veit M (2006). "Unique self-palmitoylation activity of the transport protein particle component Bet3: A mechanism required for protein stability". Proc. Natl. Acad. Sci. U.S.A. 103 (34): 12701–6. Bibcode:2006PNAS..10312701K. doi:10.1073/pnas.0603513103. PMC 1562543. PMID 16908848.

PDB gallery

1sz7: Crystal structure of Human Bet3
1wc8: THE CRYSTAL STRUCTURE OF MOUSE BET3P
1wc9: THE CRYSTAL STRUCTURE OF TRUNCATED MOUSE BET3P
2c0j: CRYSTAL STRUCTURE OF THE BET3-TRS33 HETERODIMER
2cfh: STRUCTURE OF THE BET3-TPC6B CORE OF TRAPP
2j3r: THE CRYSTAL STRUCTURE OF THE BET3-TRS31 HETERODIMER.
2j3t: THE CRYSTAL STRUCTURE OF THE BET3-TRS33-BET5-TRS23 COMPLEX.
2j3w: THE CRYSTAL STRUCTURE OF THE BET3-TRS31-SEDLIN COMPLEX.
2pwn: Crystal structure of BET3 homolog (13277653) from Mus musculus at 2.04 A resolution

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