TMPRSS11D

TMPRSS11D
Identifiers
AliasesTMPRSS11D, HAT, transmembrane protease, serine 11D, transmembrane serine protease 11D, ASP
External IDsOMIM: 605369; MGI: 2385221; HomoloGene: 74519; GeneCards: TMPRSS11D; OMA:TMPRSS11D - orthologs
Orthologs
SpeciesHumanMouse
Entrez

9407

231382

Ensembl

ENSG00000153802

ENSMUSG00000061259

UniProt

O60235

Q8VHK8

RefSeq (mRNA)

NM_004262

NM_145561

RefSeq (protein)

NP_004253

NP_663536

Location (UCSC)Chr 4: 67.82 – 67.88 MbChr 5: 86.45 – 86.52 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Transmembrane protease, serine 11D is an enzyme that in humans is encoded by the TMPRSS11D gene.[5][6][7]

This gene encodes a trypsin-like serine protease released from the submucosal serous glands onto mucous membrane. It is a type II integral membrane protein and has 29-38% identity in the sequence of the catalytic region with human hepsin, enteropeptidase, acrosin, and mast cell tryptase. The noncatalytic region has little similarity to other known proteins. This protein may play some biological role in the host defense system on the mucous membrane independently of or in cooperation with other substances in airway mucous or bronchial secretions.[7]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000153802 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000061259 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Yamaoka K, Masuda K, Ogawa H, Takagi K, Umemoto N, Yasuoka S (Jun 1998). "Cloning and characterization of the cDNA for human airway trypsin-like protease". J Biol Chem. 273 (19): 11895–901. doi:10.1074/jbc.273.19.11895. PMID 9565616.
  6. ^ Yasuoka S, Ohnishi T, Kawano S, Tsuchihashi S, Ogawara M, Masuda K, Yamaoka K, Takahashi M, Sano T (Apr 1997). "Purification, characterization, and localization of a novel trypsin-like protease found in the human airway". Am J Respir Cell Mol Biol. 16 (3): 300–8. doi:10.1165/ajrcmb.16.3.9070615. PMID 9070615.
  7. ^ a b "Entrez Gene: TMPRSS11D transmembrane protease, serine 11D". Archived from the original on 2024-04-30. Retrieved 2017-09-15.

Further reading

  • Overview of all the structural information available in the PDB for UniProt: Q8VHK8 (Mouse Transmembrane protease serine 11D) at the PDBe-KB.


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