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TAOK3
Identifiers
Aliases	TAOK3, DPK, JIK, MAP3K18, TAO kinase 3, hKFC-A
External IDs	OMIM: 616711; MGI: 3041177; HomoloGene: 83279; GeneCards: TAOK3; OMA:TAOK3 - orthologs
Gene location (Human)
Chr.	Chromosome 12 (human)
End	118,372,907 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	117,413,284 bp
RNA expression pattern
	Top expressed in
	secondary oocyte; ; monocyte; ; jejunal mucosa; ; epithelium of colon; ; bone marrow cell; ; superior vestibular nucleus; ; middle temporal gyrus; ; external globus pallidus; ; internal globus pallidus; ; corpus callosum;
	Top expressed in
	Rostral migratory stream; ; crypt of lieberkuhn of small intestine; ; ventromedial nucleus; ; supraoptic nucleus; ; conjunctival fornix; ; neural layer of retina; ; epithelium of stomach; ; lateral septal nucleus; ; mammillary body; ; retinal pigment epithelium;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	transferase activity; nucleotide binding; protein kinase activity; protein kinase inhibitor activity; kinase activity; protein serine/threonine kinase activity; protein binding; ATP binding; MAP kinase kinase kinase activity;
Cellular component	cytoplasm; membrane; plasma membrane; nucleus;
Biological process	phosphorylation; positive regulation of JUN kinase activity; positive regulation of JNK cascade; MAPK cascade; cellular response to DNA damage stimulus; negative regulation of JNK cascade; protein phosphorylation; protein autophosphorylation; mitotic G2 DNA damage checkpoint signaling; DNA repair; positive regulation of stress-activated MAPK cascade; negative regulation of protein kinase activity; nervous system development; regulation of apoptotic process; signal transduction; stress-activated protein kinase signaling cascade; activation of protein kinase activity;
	Sources:Amigo / QuickGO
Orthologs
	51347
	330177
	ENSG00000135090
	ENSMUSG00000061288
	Q9H2K8
	Q8BYC6
NM_001346487; NM_001346488; NM_001346489; NM_001346490; NM_001346491;
	NM_001346492; NM_001346493; NM_001346494; NM_001346495; NM_001346496; NM_001346497; NM_016281
	NM_001081308; NM_001199685; NM_183306
NP_001333416; NP_001333417; NP_001333418; NP_001333419; NP_001333420;
	NP_001333421; NP_001333422; NP_001333423; NP_001333424; NP_001333425; NP_001333426; NP_057365
	NP_001074777; NP_001186614; NP_899129
	Wikidata
View/Edit Human	View/Edit Mouse

Serine/threonine-protein kinase TAO3 is an enzyme that in humans is encoded by the TAOK3 gene.^[5]^[6]^[7]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000135090 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000061288 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Tassi E, Biesova Z, Di Fiore PP, Gutkind JS, Wong WT (Dec 1999). "Human JIK, a novel member of the STE20 kinase family that inhibits JNK and is negatively regulated by epidermal growth factor". J Biol Chem. 274 (47): 33287–95. doi:10.1074/jbc.274.47.33287. PMID 10559204.
^ Zhang W, Chen T, Wan T, He L, Li N, Yuan Z, Cao X (Sep 2000). "Cloning of DPK, a novel dendritic cell-derived protein kinase activating the ERK1/ERK2 and JNK/SAPK pathways". Biochem Biophys Res Commun. 274 (3): 872–9. doi:10.1006/bbrc.2000.3244. PMID 10924369.
^ "Entrez Gene: TAOK3 TAO kinase 3".

Yoneda T, Imaizumi K, Oono K, et al. (2001). "Activation of caspase-12, an endoplastic reticulum (ER) resident caspase, through tumor necrosis factor receptor-associated factor 2-dependent mechanism in response to the ER stress". J. Biol. Chem. 276 (17): 13935–40. doi:10.1074/jbc.M010677200. PMID 11278723.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Yustein JT, Xia L, Kahlenburg JM, et al. (2003). "Comparative studies of a new subfamily of human Ste20-like kinases: homodimerization, subcellular localization, and selective activation of MKK3 and p38". Oncogene. 22 (40): 6129–41. doi:10.1038/sj.onc.1206605. PMID 13679851. S2CID 21434404.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Hartmann TB, Thiel D, Dummer R, et al. (2004). "SEREX identification of new tumour-associated antigens in cutaneous T-cell lymphoma". Br. J. Dermatol. 150 (2): 252–8. doi:10.1111/j.1365-2133.2004.05651.x. PMID 14996095. S2CID 42495130.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.

This article on a gene on human chromosome 12 is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000135090 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000061288 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10559204-5] Tassi E, Biesova Z, Di Fiore PP, Gutkind JS, Wong WT (Dec 1999). "Human JIK, a novel member of the STE20 kinase family that inhibits JNK and is negatively regulated by epidermal growth factor". J Biol Chem. 274 (47): 33287–95. doi:10.1074/jbc.274.47.33287. PMID 10559204.

[pmid10924369-6] Zhang W, Chen T, Wan T, He L, Li N, Yuan Z, Cao X (Sep 2000). "Cloning of DPK, a novel dendritic cell-derived protein kinase activating the ERK1/ERK2 and JNK/SAPK pathways". Biochem Biophys Res Commun. 274 (3): 872–9. doi:10.1006/bbrc.2000.3244. PMID 10924369.

[entrez-7] "Entrez Gene: TAOK3 TAO kinase 3".

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TAOK3

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