Steven McCarroll

Steven A. McCarroll
Born
Steven Andrew McCarroll

(1970-07-13) July 13, 1970 (age 55)
Education
Scientific career
FieldsGenetics, Neuroscience
InstitutionsHarvard Medical School, Broad Institute, HHMI
ThesisThe statistical and molecular logic of gene expression patterns in Caenorhabditis elegans (2004)
Cori Bargmann
Other academic advisors
David Altshuler, Mark Daly
WebsiteMcCarroll Lab

Steven A. McCarroll is an American geneticist and neuroscientist who is the Dorothy and Milton Flier Professor of Biomedical Science and Genetics at Harvard Medical School. He is also an institute member of the Broad Institute and an HHMI investigator.

Biography

McCarroll graduated from Los Altos High School in Los Altos, California, in 1989.[1] He then studied at Stanford University, earning a B.A. in economics in 1993.[2] While at Stanford, McCarroll was a staff writer and opinions editor for The Stanford Daily newspaper.[3] After college, he worked as a fellow at the Office of Science and Technology Policy and as a research assistant at the Brookings Institution.[1] Ultimately, inspired by a former roommate who was pursuing a biochemistry Ph.D., McCarroll shifted his focus away from economics and to biology.[2] He earned a Ph.D. in neuroscience from the University of California, San Francisco in 2004, where he worked in the lab of Cori Bargmann.[4] Following his Ph.D., he worked as a postdoctoral fellow with David Altshuler and Mark Daly at Massachusetts General Hospital and the Broad Institute.[5]

Research

McCarroll's lab studies natural variation in the human brain and the ways in which genes and genetic variation shape the brain's functions and vulnerabilities.[6] Research in his lab has explored the contribution of variation in complement component 4 to schizophrenia risk,[7] revealed a mechanism by which CAG repeat expansion may drive neurodegeneration in Huntington's disease,[8] and uncovered ways in which human genetic variation influences host-microbe interactions and the oral microbiome.[9]

References

  1. ^ a b "Steven McCarroll". LinkedIn.
  2. ^ a b Sam Scott (July 2015). "A New Kind of Martian". Stanford Magazine. Retrieved October 26, 2025.
  3. ^ "Faculty baffled by budget" (PDF). Stanford Politics.
  4. ^ "People". McCarroll Lab. Retrieved October 26, 2025.
  5. ^ "Steven McCarroll, PhD". Simons Foundation. Retrieved October 26, 2025.
  6. ^ "Steve McCarroll, PhD". Broad Institute Center for Human Brain Function. Retrieved October 26, 2025.
  7. ^ Sekar A, Bialas AR, de Rivera H, Davis A, Hammond TR, Kamitaki N, Tooley K, Presumey J, Baum M, Van Doren V, Genovese G, Rose SA, Handsaker RE, Daly MJ, Carroll MC, Stevens B, McCarroll SA (January 27, 2016). "Schizophrenia risk from complex variation of complement component 4". Nature. 530 (7589): 577–583. doi:10.1038/nature16549. Retrieved October 26, 2025.
  8. ^ Handsaker RE, Kashin S, Reed NM, Tan S, Lee WS, McDonald TM, Morris K, Kamitaki N, Mullally CD, Morakabati NR, Goldman M, Lind G, Kohli R, Lawton E, Hogan M, Ichihara K, Berretta S, McCarroll SA (February 6, 2025). "Long somatic DNA-repeat expansion drives neurodegeneration in Huntington's disease". Cell. 188 (3): 623–639. doi:10.1016/j.cell.2024.11.038. Retrieved October 26, 2025.
  9. ^ Kamitaki N, Handsaker RE, Hujoel MLA, Mukamel RE, Usher CL, McCarroll SA, Loh P-R (January 28, 2026). "Human and bacterial genetic variation shape oral microbiomes and health". Nature. doi:10.1038/s41586-025-10037-7. Retrieved January 31, 2026.{{cite journal}}: CS1 maint: multiple names: authors list (link)

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