SUB1

SUB1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesSUB1, P15, PC4, p14, SUB1 homolog, transcriptional regulator, SUB1 regulator of transcription
External IDsOMIM: 600503; MGI: 104811; HomoloGene: 38218; GeneCards: SUB1; OMA:SUB1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez

10923

20024

Ensembl

ENSG00000113387

ENSMUSG00000022205

UniProt

P53999

P11031

RefSeq (mRNA)

NM_006713

NM_011294

RefSeq (protein)

NP_006704

NP_035424

Location (UCSC)Chr 5: 32.53 – 32.6 MbChr 15: 11.98 – 12 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Activated RNA polymerase II transcriptional coactivator p15 also known as positive cofactor 4 (PC4) or SUB1 homolog is a protein that in humans is encoded by the SUB1 gene.[5][6][7] The human SUB1 gene[7] is named after an orthologous gene in yeast.[8]

SUB1 is induced by oxidative stress, and is involved in coordinating cellular responses to DNA strand breaks that arise after oxidative stress.Yu L, Ma H, Ji X, Volkert MR (January 2016). "The Sub1 nuclear protein protects DNA from oxidative damage". Molecular and Cellular Biochemistry. 412 (1–2): 165–171. doi:10.1007/s11010-015-2621-x. PMC 5064834. PMID 26708217. Yeast SUB1 has structural and functional similarities to human alpha-synuclein, a protein that has an important role in Parkinson's disease.Schaser AJ, Osterberg VR, Dent SE, Stackhouse TL, Wakeham CM, Boutros SW, et al. (July 2019). "Alpha-synuclein is a DNA binding protein that modulates DNA repair with implications for Lewy body disorders". Scientific Reports. 9 (1): 10919. doi:10.1038/s41598-019-47227-z. PMC 6662836. PMID 31358782. Like SUB1, alpha-synuclein functions in regulating DNA repair including repair of DNA double-strand breaks.

Interactions

SUB1 has been shown to interact with CSTF2.[9]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000113387 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000022205 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Kretzschmar M, Kaiser K, Lottspeich F, Meisterernst M (August 1994). "A novel mediator of class II gene transcription with homology to viral immediate-early transcriptional regulators". Cell. 78 (3): 525–534. doi:10.1016/0092-8674(94)90429-4. PMID 8062392. S2CID 29077941.
  6. ^ Ge H, Roeder RG (August 1994). "Purification, cloning, and characterization of a human coactivator, PC4, that mediates transcriptional activation of class II genes". Cell. 78 (3): 513–523. doi:10.1016/0092-8674(94)90428-6. PMID 8062391. S2CID 1140379.
  7. ^ a b "Entrez Gene SUB1: SUB1 homolog (S. cerevisiae)".
  8. ^ Knaus R, Pollock R, Guarente L (April 1996). "Yeast SUB1 is a suppressor of TFIIB mutations and has homology to the human co-activator PC4". The EMBO Journal. 15 (8): 1933–1940. doi:10.1002/j.1460-2075.1996.tb00544.x. PMC 450112. PMID 8617240.
  9. ^ Calvo O, Manley JL (May 2001). "Evolutionarily conserved interaction between CstF-64 and PC4 links transcription, polyadenylation, and termination". Molecular Cell. 7 (5): 1013–1023. doi:10.1016/S1097-2765(01)00236-2. PMID 11389848.

Further reading

  • Overview of all the structural information available in the PDB for UniProt: P53999 (Activated RNA polymerase II transcriptional coactivator p15) at the PDBe-KB.
Stub icon

This article on a gene on human chromosome 5 is a stub. You can help Wikipedia by adding missing information.

Content Disclaimer

Informasi ini disarikan dari Wikipedia dan disajikan kembali untuk tujuan edukasi. Konten tersedia di bawah lisensi CC BY-SA 3.0. Kami tidak bertanggung jawab atas ketidakakuratan data yang bersumber dari kontribusi publik tersebut.

  1. The information displayed on this website is sourced in part or in whole from Wikipedia and has been adapted for the purpose of restating it. We strive to provide accurate and relevant information, however:
  2. There is no guarantee of absolute accuracy. Wikipedia is an open, collaborative project that can be edited by anyone, so information is subject to change.
  3. It is not intended to constitute professional advice. The content displayed is for informational and educational purposes only. For important decisions (e.g., medical, legal, or financial), please consult a professional.
  4. Content copyright. Wikipedia is licensed under the Creative Commons Attribution-ShareAlike License (CC BY-SA). This means that content may be reused with appropriate attribution and shared under a similar license.
  5. Responsible use. Any risk arising from the use of information from this website is entirely the responsibility of the user.