Protonitazepyne

Protonitazepyne
Identifiers
  • 5-nitro-2-(4-propoxybenzyl)-1-(2-(pyrrolidin-1-yl)ethyl)-1H-benzo[d]imidazole
CAS Number
PubChem CID
ChemSpider
UNII
Chemical and physical data
FormulaC23H28N4O3
Molar mass408.502 g·mol−1
3D model (JSmol)
  • CCCOC1=CC=C(C=C1)CC2=NC3=C(N2CCN4CCCC4)C=CC(=C3)[N+](=O)[O-]
  • InChI=1S/C23H28N4O3/c1-2-15-30-20-8-5-18(6-9-20)16-23-24-21-17-19(27(28)29)7-10-22(21)26(23)14-13-25-11-3-4-12-25/h5-10,17H,2-4,11-16H2,1H3
  • Key:KCRWXNIIXGBPID-UHFFFAOYSA-N

Protonitazepyne (N-pyrrolidino protonitazene) is a benzimidazole derivative with opioid effects, which has been sold as a designer drug over the internet, first being mentioned in mid 2022 and definitively identified in drug seizures in Canada in early 2023 and Ireland in late 2023.[1] It has since been identified by CanTEST in May 2024 in Australia[2][3] and in late 2025 in Brazil by the State University of Campinas poison control center.[4]

It is an analogue of protonitazene where the N,N-diethyl group has been substituted for pyrrolidine group. While formal studies into its pharmacology have yet to be carried out, it is has an in vitro potency approximately 350x times that of morphine.[5]

See also

References

  1. ^ Killoran S, McNamara S, Kavanagh P, O'Brien J, Lakes R (May 2024). "Identification of N-pyrrolidino protonitazene in powders sold as heroin and associated with overdose clusters in Dublin and Cork, Ireland". Drug Testing and Analysis. 17 (3): 350–357. doi:10.1002/dta.3707. PMID 38769669.
  2. ^ Curtis B, Lawes DJ, Caldicott D, McLeod MD (October 2025). "Identification of the Novel Synthetic Opioid N-Pyrrolidino Isotonitazene at an Australian Drug Checking Service". Drug Testing and Analysis. 17 (10): 1996–2004. doi:10.1002/dta.3910. PMC 12489282. PMID 40384477.
  3. ^ "N-pyrrolidino protonitazene found in brown powder sample". The Know. Australia: National Clinical Centre for Research of Emerging Drugs (NCCRED). 2024-05-18. Retrieved 2025-08-26.
  4. ^ "Unicamp identifica nova droga 50 vezes mais potente que fentanil pela 1ª vez no Brasil; entenda". G1 (in Brazilian Portuguese). 2025-10-12. Retrieved 2025-10-12.
  5. ^ De Vrieze LM, Walton SE, Pottie E, Papsun D, Logan BK, Krotulski AJ, et al. (September 2024). "In vitro structure-activity relationships and forensic case series of emerging 2-benzylbenzimidazole 'nitazene' opioids". Archives of Toxicology. 98 (9): 2999–3018. Bibcode:2024ArTox..98.2999D. doi:10.1007/s00204-024-03774-7. PMC 11324687. PMID 38877156.
Stub icon

This analgesic-related article is a stub. You can help Wikipedia by adding missing information.

Content Disclaimer

Informasi ini disarikan dari Wikipedia dan disajikan kembali untuk tujuan edukasi. Konten tersedia di bawah lisensi CC BY-SA 3.0. Kami tidak bertanggung jawab atas ketidakakuratan data yang bersumber dari kontribusi publik tersebut.

  1. The information displayed on this website is sourced in part or in whole from Wikipedia and has been adapted for the purpose of restating it. We strive to provide accurate and relevant information, however:
  2. There is no guarantee of absolute accuracy. Wikipedia is an open, collaborative project that can be edited by anyone, so information is subject to change.
  3. It is not intended to constitute professional advice. The content displayed is for informational and educational purposes only. For important decisions (e.g., medical, legal, or financial), please consult a professional.
  4. Content copyright. Wikipedia is licensed under the Creative Commons Attribution-ShareAlike License (CC BY-SA). This means that content may be reused with appropriate attribution and shared under a similar license.
  5. Responsible use. Any risk arising from the use of information from this website is entirely the responsibility of the user.