DOKUMEN123.COM

PSMA8
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4R3O, 4R67
Identifiers
Aliases	PSMA8, PSMA7L, proteasome subunit alpha 8, proteasome 20S subunit alpha 8
External IDs	OMIM: 617841; MGI: 1920927; HomoloGene: 2086; GeneCards: PSMA8; OMA:PSMA8 - orthologs
Gene location (Human)
Chr.	Chromosome 18 (human)
End	26,193,355 bp
Gene location (Mouse)
Chr.	Chromosome 18 (mouse)
End	14,895,358 bp
RNA expression pattern
	Top expressed in
	right testis; ; sperm; ; left testis; ; testicle; ; buccal mucosa cell; ; gonad; ; lymph node; ; granulocyte; ; appendix; ; pharynx;
	Top expressed in
	spermatocyte; ; spermatid; ; seminiferous tubule; ; blastocyst; ; embryo; ; embryo; ; endocardial cushion; ; atrioventricular valve; ; morula; ; Gonadal ridge;
	More reference expression data
	n/a
Gene ontology
Molecular function	endopeptidase activity; peptidase activity; threonine-type endopeptidase activity; hydrolase activity;
Cellular component	cytoplasm; cytosol; spermatoproteasome complex; proteasome complex; extracellular exosome; nucleus; proteasome core complex; proteasome core complex, alpha-subunit complex;
Biological process	regulation of cellular amino acid metabolic process; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; regulation of mRNA stability; ubiquitin-dependent protein catabolic process; positive regulation of canonical Wnt signaling pathway; protein polyubiquitination; stimulatory C-type lectin receptor signaling pathway; tumor necrosis factor-mediated signaling pathway; MAPK cascade; proteolysis; Fc-epsilon receptor signaling pathway; NIK/NF-kappaB signaling; anaphase-promoting complex-dependent catabolic process; proteolysis involved in cellular protein catabolic process; T cell receptor signaling pathway; negative regulation of canonical Wnt signaling pathway; Wnt signaling pathway, planar cell polarity pathway; proteasome-mediated ubiquitin-dependent protein catabolic process; negative regulation of G2/M transition of mitotic cell cycle; protein deubiquitination; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; transmembrane transport; regulation of transcription from RNA polymerase II promoter in response to hypoxia; post-translational protein modification; regulation of hematopoietic stem cell differentiation; proteasomal protein catabolic process; proteasomal ubiquitin-independent protein catabolic process; interleukin-1-mediated signaling pathway; regulation of mitotic cell cycle phase transition;
	Sources:Amigo / QuickGO
Orthologs
	143471
	73677
	ENSG00000154611
	ENSMUSG00000036743
	Q8TAA3
	Q9CWH6
	NM_001025096; NM_001025097; NM_001308188; NM_144662
	NM_001163609; NM_001360823
	NP_001020267; NP_001020268; NP_001295117; NP_653263
	NP_001157081; NP_001347752
	Wikidata
View/Edit Human	View/Edit Mouse

Proteasome subunit alpha 8 also known as proteasome subunit alpha type-7-like is a protein that in humans is encoded by the PSMA8 gene.^[5] Proteasome subunit alpha 8 is a component of the sperm specific proteasome.^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000154611 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000036743 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: PSMA8 proteasome subunit alpha 8".
^ de Mateo S, Castillo J, Estanyol JM, Ballescà JL, Oliva R (2011). "Proteomic characterization of the human sperm nucleus". Proteomics. 11 (13): 2714–26. doi:10.1002/pmic.201000799. PMID 21630459. S2CID 9305926.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000154611 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000036743 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: PSMA8 proteasome subunit alpha 8".

[pmid21630459-6] Mateo S, Castillo J, Estanyol JM, Ballescà JL, Oliva R (2011). "Proteomic characterization of the human sperm nucleus". Proteomics. 11 (13): 2714–26. doi:10.1002/pmic.201000799. PMID 21630459. S2CID 9305926.

[1]

[2]

[3]

[4]

[5]

[6]

v t e Proteasome endopeptidase complex subunits (EC 3.4.25.1)
A (alpha subunits)	PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMA8
B (beta subunits)	PSMB1 PSMB2 PSMB3 PSMB4 PSMB5 PSMB6 PSMB7 PSMB8 PSMB9 PSMB10
C (ATPases)	PSMC1 PSMC2 PSMC3 PSMC4 PSMC5 PSMC6
D (non-ATPases)	PSMD1 PSMD2 PSMD3 PSMD4 PSMD5 PSMD6 PSMD7 PSMD8 PSMD9 PSMD10 PSMD11 PSMD12 PSMD13 PSMD14
E (activator subunits)	PSME1 PSME2 PSME3 PSME4
F (inhibitor subunit)	PSMF1

PSMA8

References

Content Disclaimer