PCDHB12

PCDHB12
Identifiers
AliasesPCDHB12, PCDH-BETA12, protocadherin beta 12
External IDsOMIM: 606338; MGI: 2136757; HomoloGene: 128411; GeneCards: PCDHB12; OMA:PCDHB12 - orthologs
Orthologs
SpeciesHumanMouse
Entrez

56124

93890

Ensembl

ENSG00000120328

ENSMUSG00000043313

UniProt

Q9Y5F1

n/a

RefSeq (mRNA)

NM_018932

NM_053144

RefSeq (protein)

NP_061755

n/a

Location (UCSC)Chr 5: 141.21 – 141.21 MbChr 18: 37.63 – 37.64 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Protocadherin beta-12 is a protein that in humans is encoded by the PCDHB12 gene.[5][6]

This gene is a member of the protocadherin beta gene cluster, one of three related gene clusters tandemly linked on chromosome five. The gene clusters demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene clusters. The beta cluster contains 16 genes and 3 pseudogenes, each encoding 6 extracellular cadherin domains and a cytoplasmic tail that deviates from others in the cadherin superfamily. The extracellular domains interact in a homophilic manner to specify differential cell-cell connections. Unlike the alpha and gamma clusters, the transcripts from these genes are made up of only one large exon, not sharing common 3' exons as expected. These neural cadherin-like cell adhesion proteins are integral plasma membrane proteins. Their specific functions are unknown but they most likely play a critical role in the establishment and function of specific cell-cell neural connections.[6]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000120328 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000043313 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Wu Q, Maniatis T (Jul 1999). "A striking organization of a large family of human neural cadherin-like cell adhesion genes". Cell. 97 (6): 779–90. doi:10.1016/S0092-8674(00)80789-8. PMID 10380929. S2CID 6014717.
  6. ^ a b "Entrez Gene: PCDHB12 protocadherin beta 12".

Further reading


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