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OSBPL1A
Identifiers
Aliases	OSBPL1A, ORP-1, ORP1, OSBPL1B, oxysterol binding protein like 1A
External IDs	OMIM: 606730; MGI: 1927551; HomoloGene: 84746; GeneCards: OSBPL1A; OMA:OSBPL1A - orthologs
Gene location (Human)
Chr.	Chromosome 18 (human)
End	24,397,880 bp
Gene location (Mouse)
Chr.	Chromosome 18 (mouse)
End	13,074,898 bp
RNA expression pattern
	Top expressed in
	corpus callosum; ; internal globus pallidus; ; inferior ganglion of vagus nerve; ; postcentral gyrus; ; external globus pallidus; ; subthalamic nucleus; ; pons; ; pars reticulata; ; lateral nuclear group of thalamus; ; occipital lobe;
	Top expressed in
	prefrontal cortex; ; deep cerebellar nuclei; ; barrel cortex; ; medial geniculate nucleus; ; primary motor cortex; ; medial dorsal nucleus; ; pontine nuclei; ; lateral geniculate nucleus; ; medial vestibular nucleus; ; olfactory epithelium;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	cholesterol binding; protein binding; phospholipid binding; lipid binding; sterol transporter activity; sterol binding;
Cellular component	endosome; late endosome; intracellular anatomical structure; extracellular exosome; cytosol; membrane; intracellular membrane-bounded organelle;
Biological process	lipid transport; cholesterol metabolic process; antigen processing and presentation of exogenous peptide antigen via MHC class II; vesicle-mediated transport; bile acid biosynthetic process; sterol transport; transport;
	Sources:Amigo / QuickGO
Orthologs
	114876
	64291
	ENSG00000141447
	ENSMUSG00000044252
	Q9BXW6
	Q91XL9
	NM_001242508; NM_018030; NM_080597; NM_133268
NM_001252489; NM_001252490; NM_001252491; NM_001252492; NM_001252493;
	NM_020573; NM_207530
	NP_001229437; NP_060500; NP_542164
NP_001239418; NP_001239419; NP_001239420; NP_001239421; NP_001239422;
	NP_997413
	Wikidata
View/Edit Human	View/Edit Mouse

Oxysterol-binding protein-related protein 1 is a protein that in humans is encoded by the OSBPL1A gene.^[5]^[6]^[7]

This gene encodes a member of the oxysterol-binding protein (OSBP) family, a group of intracellular lipid receptors. Most members contain an N-terminal pleckstrin homology domain and a highly conserved C-terminal OSBP-like sterol-binding domain, although some members contain only the sterol-binding domain. Transcript variants derived from alternative promoter usage and/or alternative splicing exist; they encode different isoforms.^[7]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000141447 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000044252 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Xu Y, Liu Y, Ridgway ND, McMaster CR (May 2001). "Novel members of the human oxysterol-binding protein family bind phospholipids and regulate vesicle transport". J Biol Chem. 276 (21): 18407–14. doi:10.1074/jbc.M101204200. PMID 11279184.
^ Laitinen S, Olkkonen VM, Ehnholm C, Ikonen E (Feb 2000). "Family of human oxysterol binding protein (OSBP) homologues. A novel member implicated in brain sterol metabolism". J Lipid Res. 40 (12): 2204–11. doi:10.1016/S0022-2275(20)32095-2. PMID 10588946.
^ ^a ^b "Entrez Gene: OSBPL1A oxysterol binding protein-like 1A".

Lehto M, Laitinen S, Chinetti G, et al. (2001). "The OSBP-related protein family in humans". J. Lipid Res. 42 (8): 1203–13. doi:10.1016/S0022-2275(20)31570-4. PMID 11483621.
Jaworski CJ, Moreira E, Li A, et al. (2002). "A family of 12 human genes containing oxysterol-binding domains". Genomics. 78 (3): 185–96. doi:10.1006/geno.2001.6663. PMID 11735225.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Johansson M, Bocher V, Lehto M, et al. (2004). "The two variants of oxysterol binding protein-related protein-1 display different tissue expression patterns, have different intracellular localization, and are functionally distinct". Mol. Biol. Cell. 14 (3): 903–15. doi:10.1091/mbc.E02-08-0459. PMC 151568. PMID 12631712.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Johansson M, Lehto M, Tanhuanpää K, et al. (2006). "The oxysterol-binding protein homologue ORP1L interacts with Rab7 and alters functional properties of late endocytic compartments". Mol. Biol. Cell. 16 (12): 5480–92. doi:10.1091/mbc.E05-03-0189. PMC 1289395. PMID 16176980.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.

This article on a gene on human chromosome 18 is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000141447 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000044252 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11279184-5] Xu Y, Liu Y, Ridgway ND, McMaster CR (May 2001). "Novel members of the human oxysterol-binding protein family bind phospholipids and regulate vesicle transport". J Biol Chem. 276 (21): 18407–14. doi:10.1074/jbc.M101204200. PMID 11279184.

[pmid10588946-6] Laitinen S, Olkkonen VM, Ehnholm C, Ikonen E (Feb 2000). "Family of human oxysterol binding protein (OSBP) homologues. A novel member implicated in brain sterol metabolism". J Lipid Res. 40 (12): 2204–11. doi:10.1016/S0022-2275(20)32095-2. PMID 10588946.

[entrez-7] "Entrez Gene: OSBPL1A oxysterol binding protein-like 1A".

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OSBPL1A

References

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