Nitroxinil

Nitroxinil
Structure of nitroxinil
Clinical data
Trade namesFluconix, Dovenix, Trodax
Other namesNitroxynil
Routes of
administration		Subcutaneous in the form of an N-Ethylglucamine salt solution
ATCvet code
Identifiers
  • 4-Hydroxy-3-iodo-5-nitrobenzonitrile
CAS Number
PubChem CID
UNII
CompTox Dashboard (EPA)
ECHA InfoCard100.015.350 Edit this at Wikidata
Chemical and physical data
FormulaC7H3IN2O3
Molar mass290.016 g·mol−1
3D model (JSmol)
Melting point136–139 °C (277–282 °F)
  • C1=C(C=C(C(=C1[N+](=O)[O-])O)I)C#N
  • InChI=1S/C7H3IN2O3/c8-5-1-4(3-9)2-6(7(5)11)10(12)13/h1-2,11H

Nitroxinil is an anthelmintic, a veterinary medicine against parasitic worms in sheep and cattle.[1] The substance is active against the liver fluke the Fasciola hepatica and to a lesser extent against thread worms in the gastrointestinal tract.[2] Brand names include Fluconix, Dovenix and Trodax. Nitroxynil is also used against strains of the red gum worm (Haemonchus contortus) that have become resistant to benzimidazoles.[citation needed]

Nitroxinil was invented by May & Baker[3] in the mid 1960s as part of a program into investigation of derivatives of p-hydroxybenzonitrile. In addition to nitroxynil, the herbicides ioxynil (3,5-diiodo) and bromoxynil (3,5-dibromo) were also invented by the same company. Nitroxynil has a nitro group in addition to a single iodine group.

Nitroxynil is almost insoluble in water. It is usually injected subcutaneously into the animals in the form of the water-soluble ethylglucamine salt.[2] It must not be administered to animals that produce milk for human consumption.[4]

References

  1. ^ Eghianruwa K (2014). "Nitroxinil". Essential Drug Data for Rational Therapy in Veterinary Practice. UK: AuthorHouse. pp. 299–300. ISBN 978-1-4918-0010-2.
  2. ^ a b "NITROXINIL = NITROXYNIL for veterinary use in CATTLE, SHEEP and GOATS against flukes and roundworms". Retrieved 4 April 2018.
  3. ^ GB 1104885, May & Baker, "Method for the Treatment of Helminth Infestations", published 18 Dec 1964, issued 6 Mar 1968 
  4. ^ "Committee for Veterinary Medicinal Products, Nitroxinil, Summary Report" (PDF). The European Agency for the Evaluation of Medical Products. June 1998. p. 5. Retrieved 4 April 2018.

Content Disclaimer

Informasi ini disarikan dari Wikipedia dan disajikan kembali untuk tujuan edukasi. Konten tersedia di bawah lisensi CC BY-SA 3.0. Kami tidak bertanggung jawab atas ketidakakuratan data yang bersumber dari kontribusi publik tersebut.

  1. The information displayed on this website is sourced in part or in whole from Wikipedia and has been adapted for the purpose of restating it. We strive to provide accurate and relevant information, however:
  2. There is no guarantee of absolute accuracy. Wikipedia is an open, collaborative project that can be edited by anyone, so information is subject to change.
  3. It is not intended to constitute professional advice. The content displayed is for informational and educational purposes only. For important decisions (e.g., medical, legal, or financial), please consult a professional.
  4. Content copyright. Wikipedia is licensed under the Creative Commons Attribution-ShareAlike License (CC BY-SA). This means that content may be reused with appropriate attribution and shared under a similar license.
  5. Responsible use. Any risk arising from the use of information from this website is entirely the responsibility of the user.