Neuron derived neurotrophic factor

3D protein structure of the NDNF gene as based on an Alphafold model.
NDNF
Identifiers
AliasesNDNF, C4orf31, NORD, neuron-derived neurotrophic factor, neuron derived neurotrophic factor, HH25
External IDsOMIM: 616506; MGI: 1915419; HomoloGene: 11593; GeneCards: NDNF; OMA:NDNF - orthologs
Orthologs
SpeciesHumanMouse
Entrez

79625

68169

Ensembl

ENSG00000173376

ENSMUSG00000049001

UniProt

Q8TB73

Q8C119

RefSeq (mRNA)

NM_024574

NM_172399

RefSeq (protein)

NP_078850

NP_765987

Location (UCSC)Chr 4: 121.04 – 121.07 MbChr 6: 65.65 – 65.69 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Neuron derived neurotrophic factor (NDNF) is a secreted protein that, in humans, is located on chromosome 4.[5] This protein helps in the growth, survival, migration, and differentiation of neurons.[6] To assist with migration, NDNF shows neuro-repulsive effects on GnRH neurons. Loss of function (LoF) in the NDNF gene has been shown to be a cause of a disease known as congenital hypogonadotropic hypogonadism, which can have associated cleft lip and cleft palate.[7] A preliminary study has shown that knock-down of ndnf reduces development of the ethmoid plate, which is homologous to the human palate.[8][9]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000173376 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000049001 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "NDNF neuron derived neurotrophic factor [Homo sapiens (human)] - Gene - NCBI". www.ncbi.nlm.nih.gov. Retrieved 2023-05-12.
  6. ^ Kuang XL, Zhao XM, Xu HF, Shi YY, Deng JB, Sun GT (October 2010). "Spatio-temporal expression of a novel neuron-derived neurotrophic factor (NDNF) in mouse brains during development". BMC Neuroscience. 11 (1): 137. doi:10.1186/1471-2202-11-137. PMC 2984559. PMID 20969804.
  7. ^ Messina A, Pulli K, Santini S, Acierno J, Känsäkoski J, Cassatella D, et al. (January 2020). "Neuron-Derived Neurotrophic Factor Is Mutated in Congenital Hypogonadotropic Hypogonadism". American Journal of Human Genetics. 106 (1): 58–70. doi:10.1016/j.ajhg.2019.12.003. PMC 7042563. PMID 31883645.
  8. ^ Swartz ME, Sheehan-Rooney K, Dixon MJ, Eberhart JK (September 2011). "Examination of a palatogenic gene program in zebrafish". Developmental Dynamics. 240 (9): 2204–2220. doi:10.1002/dvdy.22713. PMC 3202344. PMID 22016187.
  9. ^ Melvin VS, Feng W, Hernandez-Lagunas L, Artinger KB, Williams T (July 2013). "A morpholino-based screen to identify novel genes involved in craniofacial morphogenesis". Developmental Dynamics. 242 (7): 817–831. doi:10.1002/dvdy.23969. PMC 4027977. PMID 23559552.

Further reading

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