MSCRAMM

MSCRAMM (acronym for "microbial surface components recognizing adhesive matrix molecules") are adhesin proteins that mediate the initial attachment of bacteria to host tissue, providing a critical step to establish infection.[1]

Examples include clumping factor A (ClfA), fibronectin binding protein A (FnbpA) from Staphylococcus aureus, SdrG from Staphylococcus epidermidis, M protein from Streptococcus pyogenes, and protein G in other Streptococcus species. All of these MSCRAMMs bind to fibrinogen, but also other targets for MSCRAMMs are known, such as fibronectin. Protein M binds to the Fc region of certain antibodies.

The MSCRAMMs have mainly been studied in Gram positive pathogens and are promising drug targets.

The monoclonal antibody tefibazumab targets ClfA and has been tested in a phase II trial.

Staphylococcus aureus

An example for MSCRAMMs is S. aureus. On its surface, protein A is expressed, which binds to the Fc region of IgG antibodies (the default antibody type, dealing with bacterial and viral infections). This has an antiphagocytic effect, i.e. macrophages cannot "see" these bacteria as easily as if they were correctly opsonised by antigen. Also, S. aureus expresses fibronectin-binding proteins, which promote binding to mucosal cells and tissue matrices. This protein is also referred to as clumping factor.

References

  1. ^ Abdolmajid Ghasemian; Shahin Najar Peerayeh; Bita Bakhshi; Mohsen Mirzaee (27 September 2014). "The Microbial Surface Components Recognizing Adhesive Matrix Molecules (MSCRAMMs) Genes among Clinical Isolates of Staphylococcus aureus from Hospitalized Children". Iranian Journal of Pathology. 10 (4): 258–64. PMC 4539745. PMID 26351495.


Stub icon

This protein-related article is a stub. You can help Wikipedia by adding missing information.

Content Disclaimer

Informasi ini disarikan dari Wikipedia dan disajikan kembali untuk tujuan edukasi. Konten tersedia di bawah lisensi CC BY-SA 3.0. Kami tidak bertanggung jawab atas ketidakakuratan data yang bersumber dari kontribusi publik tersebut.

  1. The information displayed on this website is sourced in part or in whole from Wikipedia and has been adapted for the purpose of restating it. We strive to provide accurate and relevant information, however:
  2. There is no guarantee of absolute accuracy. Wikipedia is an open, collaborative project that can be edited by anyone, so information is subject to change.
  3. It is not intended to constitute professional advice. The content displayed is for informational and educational purposes only. For important decisions (e.g., medical, legal, or financial), please consult a professional.
  4. Content copyright. Wikipedia is licensed under the Creative Commons Attribution-ShareAlike License (CC BY-SA). This means that content may be reused with appropriate attribution and shared under a similar license.
  5. Responsible use. Any risk arising from the use of information from this website is entirely the responsibility of the user.