MSB may refer to:

Business

• Major Season Blackball A Blackball League In Australia And New Zealand
• Money services business, a legal term used by financial regulators to describe businesses that transmit or convert money

Culture

• The Magic School Bus, a series of children's books about science
• Mario Slam Basketball, a 2006 video game for the Nintendo DS; aka Mario Hoops 3-on-3
• Mario Superstar Baseball, a 2005 video game for the Nintendo GameCube
• Le Mans Sarthe Basket a French basketball team
• Megalo Strike Back, a song by Toby Fox on the album EarthBound: I Miss You (2012)
• Melbourne Staff Band, the premier brass band of the Salvation Army in Australia
• Michael Stanley Band, a heartland rock band from Cleveland, United States
  • MSB (album), a 1982 studio album by Michael Stanley
• Myanmar Standard Bible, a translation of the Bible into the Burmese language

Government and politics

• Main Support Battalion, a former U.S. Army logistics formation
• Maritime Services Board, a former government agency in New South Wales, Australia
• Bureau of Investigation and Statistics (Military Investigation and Statistics Bureau), the military intelligence agency of the Republic of China before 1946.
• Myndigheten för samhällsskydd och beredskap, the Swedish Civil Contingencies Agency

Science and technology

• Media Stream Broadcast, a communications protocol by Microsoft
• 1,4-Bis(2-methylstyryl) benzene, also known as p-Bis(o-methylstyryl) benzene and abbreviated Bis-MSB, a wavelength shifting compound used in liquid scintillators
• Microsoft Surface Book, a portable computer
• Millennium Seed Bank, an international conservation project for storing plant seeds
• Molecular Systems Biology, an open-access, peer-reviewed scientific journal
• Most significant bit, the bit with the highest significance in a word
• Most significant byte, the highest byte in a multi-byte number
• Mrs. Stewart's Bluing, a brand of fabric bluing agent
• MSB, the Southern Railway station code for Chennai Beach railway station, Chennai, India

Educational institutions

• Marriott School of Business at Brigham Young University
• Mason School of Business at the College of William & Mary
• McDonough School of Business at Georgetown University
• Mediterranean School of Business, is the first Business School of South Mediterranean University (SMU) in Tunisia
• Michigan School for the Blind, a school for the blind in Michigan, United States
• Minnesota School of Business & Globe University, a higher education network based in Minnesota, United States
• Mississippi School for the Blind, a school for the blind in Mississippi, United States
• Missouri School for the Blind, a school for the Missouri, United States
• MSB Educational Institute, a world-wide network of Islamic schools
• Mount St Benedict College, a school in Sydney, Australia

Other

• Medical Sciences Building (University of Toronto)

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