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mixed-lineage leukemia 1 (MLL1), or zinc finger protein HRX (HRX), is an enzyme that in humans is encoded by the KMT2A gene. MLL1 is a histone methyltransferase...

and degrade noncoding RNAs. Cyp33 in mammals causes isomerization in MLL1. MLL1 is a multiprotein complex that regulates gene expression and chromosomal...

suppressing the activity of the histone methyltransferase MLL1, also known as KMT2A. The inhibition of MLL1 via the small-molecule inhibitor MM-401 in EpiSCs...

family of six Set1-like H3K4 methyltransferases that also contains KMT2A (or MLL1), KMT2B (or MLL2), KMT2C (or MLL3), KMT2F (or SET1A), and KMT2G (or SET1B)...

that of the TrxG-related H3K4-HMTase MLL1; however, ASH1L's association with chromatin can occur independently of MLL1. While ASH1L binds to the 5'-transcribed...

body nuclear speck U4/U6 x U5 tri-snRNP complex U4atac snRNP nucleoplasm MLL1 complex U2-type spliceosomal complex precatalytic spliceosome spliceosomal...

lysines. The COMPASS complex is an example of a trithorax-group protein. The MLL1/SET domain associated with the COMPASS complex have crystal structure. The...

"Physical association and coordinate function of the H3 K4 methyltransferase MLL1 and the H4 K16 acetyltransferase MOF". Cell. 121 (6): 873–85. doi:10.1016/j...

histone binding armadillo repeat domain binding Cellular component nucleoplasm MLL1 complex nucleus protein-containing complex Biological process regulation...

SASP expression is induced by a number of transcription factors, including MLL1 (KMT2A), C/EBPβ, and NF-κB. NF-κB and the enzyme CD38 are mutually activating...

activity, RNA polymerase II-specific Cellular component nucleus nucleoplasm MLL1 complex Biological process regulation of transcription, DNA-templated transcription...

"Physical association and coordinate function of the H3 K4 methyltransferase MLL1 and the H4 K16 acetyltransferase MOF". Cell. 121 (6): 873–85. doi:10.1016/j...

2006). "Histone H3 recognition and presentation by the WDR5 module of the MLL1 complex". Nature Structural & Molecular Biology. 13 (8): 704–12. doi:10.1038/nsmb1119...

acetyltransferase complex intracellular anatomical structure nucleoplasm MLL1 complex extracellular exosome nucleus Swr1 complex R2TP complex cytoplasm...

H3K4me3Q5his was also found to inhibit the H3K4 methyltransferase activities of MLL1-4 and SETD1A/B complexes, all of which require WDR5 as a co-factor. Taken...

Q (March 2021). "Long non-coding RNA ROR recruits histone transmethylase MLL1 to up-regulate TIMP3 expression and promote breast cancer progression". Journal...

ontology Molecular function molecular function Cellular component nucleus MLL1 complex Ino80 complex fibrillar center nucleoplasm Biological process regulation...

protein binding RNA binding Cellular component nucleus membrane cytoplasm MLL1 complex nucleoplasm nucleolus Biological process positive regulation of transcription...

transcription factor TFTC complex transcription factor TFIID complex nucleoplasm MLL1 complex nucleus cytosol protein-containing complex Biological process regulation...

Histone-lysine N-methyltransferase 2A, also known as mixed-lineage leukemia 1 (MLL1), is associated with acute lymphoblastic leukemia. KMT2A–AFF1, or MLL-AFF1...

nuclear membrane histone acetyltransferase complex nucleus nucleoplasm cytosol MLL1 complex Biological process histone H4-K16 acetylation regulation of transcription...

component cytoplasm membrane SAGA-type complex Set1C/COMPASS complex axon soma MLL1 complex dendrite histone acetyltransferase complex nucleus nucleoplasm protein-containing...

histone acetyltransferase complex nucleoplasm microtubule organizing center MLL1 complex extracellular exosome cytoskeleton nucleus Swr1 complex R2TP complex...

"Physical association and coordinate function of the H3 K4 methyltransferase MLL1 and the H4 K16 acetyltransferase MOF". Cell. 121 (6): 873–85. doi:10.1016/j...

transcription initiation factor activity Cellular component nucleoplasm MLL1 complex nucleus nucleolus transcription regulator complex transcription factor...

2006). "Histone H3 recognition and presentation by the WDR5 module of the MLL1 complex". Nat. Struct. Mol. Biol. 13 (8): 704–12. doi:10.1038/nsmb1119. PMC 4698793...

ontology Molecular function protein binding Cellular component cytoplasm MLL1 complex nucleolus nucleus Rix1 complex nucleoplasm Biological process rRNA...

Cellular component cytoplasm Golgi apparatus transcription factor TFTC complex MLL1 complex cyclin/CDK positive transcription elongation factor complex nucleus...

"Physical association and coordinate function of the H3 K4 methyltransferase MLL1 and the H4 K16 acetyltransferase MOF". Cell. 121 (6): 873–85. doi:10.1016/j...

acetyltransferase binding Cellular component histone acetyltransferase complex MLL1 complex chromosome, centromeric region nucleus kinetochore chromosome nucleoplasm...

Molecular function RNA binding endonuclease activity Cellular component MLL1 complex nucleolus membrane nucleus nucleoplasm cytoplasm preribosome, large...

deficient in a particular histone-methyltransferase gene, KMT2A (also known as MLL1), in adult excitatory neurons show impairments in hippocampus-dependent memory...

Canaani E, Young RA (June 2005). "Global and Hox-specific roles for the MLL1 methyltransferase". Proceedings of the National Academy of Sciences of the...

hydrolase activity Cellular component cytoplasm nucleolus nucleus nucleoplasm MLL1 complex Biological process proteolysis rRNA processing protein desumoylation...

N-methyltransferase activity DNA binding Cellular component nucleoplasm MLL1 complex MLL3/4 complex nucleus histone methyltransferase complex Set1C/COMPASS...

PMID 21677750. Goveas, Neethu; Waskow, Claudia; Arndt, Katharina; et al. (2021). "MLL1 is required for maintenance of intestinal stem cells". PLOS Genetics. 17...

to bind directly to TAF9: p53, VP16, HSF1, NF-IL6, NFAT1, NF-κB, and ALL1/MLL1. Inside of these 17 amino acids, a unique Nine-amino-acid transactivation...

dendrite cytoplasm polysome perikaryon endoplasmic reticulum Ino80 complex MLL1 complex NSL complex Biological process positive regulation of protein localization...

heterodimerization activity aryl hydrocarbon receptor binding Cellular component MLL1 complex transcription factor TFTC complex cytosol nucleus nucleoplasm SAGA...

cell projection dendrite nucleus nucleoplasm cytoplasm protein-DNA complex MLL1 complex RNA polymerase II transcription regulator complex Biological process...