MED28

MED28
Identifiers
AliasesMED28, 1500003D12Rik, EG1, magicin, mediator complex subunit 28
External IDsOMIM: 610311; MGI: 1914249; HomoloGene: 11873; GeneCards: MED28; OMA:MED28 - orthologs
Orthologs
SpeciesHumanMouse
Entrez

80306

66999

Ensembl

ENSG00000118579

ENSMUSG00000015804

UniProt

Q9H204

Q920D3

RefSeq (mRNA)

NM_025205

NM_025895

RefSeq (protein)

NP_079481

NP_080171

Location (UCSC)Chr 4: 17.61 – 17.63 MbChr 5: 45.68 – 45.69 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse
Med28
Identifiers
SymbolMed28
PfamPF11594
InterProIPR021640
Available protein structures:
PDB  IPR021640 PF11594 (ECOD; PDBsum)  
AlphaFold

Mediator of RNA polymerase II transcription subunit 28 is an enzyme that in humans is encoded by the MED28 gene.[5][6][7] It forms part of the Mediator complex.


Function

Subunit Med28 of the Mediator may function as a scaffolding protein within Mediator by maintaining the stability of a submodule within the head module, and components of this submodule act together in a gene-regulatory programme to suppress smooth muscle cell differentiation. Thus, mammalian Mediator subunit Med28 functions as a repressor of smooth muscle-cell differentiation, which could have implications for disorders associated with abnormalities in smooth muscle cell growth and differentiation, including atherosclerosis, asthma, hypertension, and smooth muscle tumours.[8]

Interactions

MED28 has been shown to interact with Merlin,[6] Grb2[6] and MED26.[9]

See also

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000118579 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000015804 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Liu C, Zhang L, Shao ZM, Beatty P, Sartippour M, Lane TF, Barsky SH, Livingston E, Nguyen M (Jan 2002). "Identification of a novel endothelial-derived gene EG-1". Biochemical and Biophysical Research Communications. 290 (1): 602–12. doi:10.1006/bbrc.2001.6119. PMID 11779215.
  6. ^ a b c Wiederhold T, Lee MF, James M, Neujahr R, Smith N, Murthy A, Hartwig J, Gusella JF, Ramesh V (Nov 2004). "Magicin, a novel cytoskeletal protein associates with the NF2 tumor suppressor merlin and Grb2". Oncogene. 23 (54): 8815–25. doi:10.1038/sj.onc.1208110. PMID 15467741.
  7. ^ "Entrez Gene: MED28 mediator of RNA polymerase II transcription, subunit 28 homolog (S. cerevisiae)".
  8. ^ Beyer KS, Beauchamp RL, Lee MF, Gusella JF, Näär AM, Ramesh V (Nov 2007). "Mediator subunit MED28 (Magicin) is a repressor of smooth muscle cell differentiation". The Journal of Biological Chemistry. 282 (44): 32152–7. doi:10.1074/jbc.M706592200. PMID 17848560.
  9. ^ Sato S, Tomomori-Sato C, Parmely TJ, Florens L, Zybailov B, Swanson SK, Banks CA, Jin J, Cai Y, Washburn MP, Conaway JW, Conaway RC (Jun 2004). "A set of consensus mammalian mediator subunits identified by multidimensional protein identification technology". Molecular Cell. 14 (5): 685–91. doi:10.1016/j.molcel.2004.05.006. PMID 15175163.
This article incorporates text from the public domain Pfam and InterPro: IPR021640

Further reading


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