LCOR

LCOR
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesLCOR, MLR2, ligand dependent nuclear receptor corepressor, C10orf12
External IDsOMIM: 607698; MGI: 2443930; HomoloGene: 22914; GeneCards: LCOR; OMA:LCOR - orthologs
Orthologs
SpeciesHumanMouse
Entrez

84458

212391

Ensembl

ENSG00000196233

ENSMUSG00000025019

UniProt

Q96JN0

Q6ZPI3

RefSeq (mRNA)

NM_001170765
NM_001170766
NM_001346516
NM_015652
NM_032440

NM_172154
NM_001370767

RefSeq (protein)

NP_001164236
NP_001164237
NP_001333445
NP_115816

NP_742166
NP_001357696

Location (UCSC)Chr 10: 96.83 – 97 MbChr 19: 41.47 – 41.57 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Ligand-dependent corepressor is a protein that in humans is encoded by the LCOR gene.[5][6][7]

Function

LCOR is a transcriptional corepressor widely expressed in fetal and adult tissues that is recruited to agonist-bound nuclear receptors through a single LxxLL motif, also referred to as a nuclear receptor (NR) box.[7]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000196233 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000025019 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Fernandes I, Bastien Y, Wai T, Nygard K, Lin R, Cormier O, Lee HS, Eng F, Bertos NR, Pelletier N, Mader S, Han VK, Yang XJ, White JH (Jan 2003). "Ligand-dependent nuclear receptor corepressor LCoR functions by histone deacetylase-dependent and -independent mechanisms". Mol Cell. 11 (1): 139–50. doi:10.1016/S1097-2765(03)00014-5. PMID 12535528.
  6. ^ White JH, Fernandes I, Mader S, Yang XJ (Jun 2004). "Corepressor recruitment by agonist-bound nuclear receptors". Vitam Horm. Vitamins & Hormones. 68: 123–43. doi:10.1016/S0083-6729(04)68004-6. ISBN 978-0-12-709868-5. PMID 15193453.
  7. ^ a b "Entrez Gene: LCOR ligand dependent nuclear receptor corepressor".

Further reading

  • PDBe-KB provides an overview of all the structure information available in the PDB for Human Ligand-dependent corepressor



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