L3MBTL

L3MBTL1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesL3MBTL1, H-L(3)MBT, L3MBTL, ZC2HC3, dJ138B7.3, l(3)mbt-like 1 (Drosophila), histone methyl-lysine binding protein, L3MBTL histone methyl-lysine binding protein 1
External IDsOMIM: 608802; MGI: 2676663; HomoloGene: 41846; GeneCards: L3MBTL1; OMA:L3MBTL1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez

26013

241764

Ensembl

ENSG00000185513

ENSMUSG00000035576

UniProt

Q9Y468

A2A5N8

RefSeq (mRNA)

NM_032107
NM_015478

NM_001081338

RefSeq (protein)

NP_056293
NP_115479

NP_001074807

Location (UCSC)Chr 20: 43.49 – 43.55 MbChr 2: 162.94 – 162.97 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Lethal(3)malignant brain tumor-like protein is a protein that in humans is encoded by the L3MBTL gene.[5][6][7]

This gene encodes the homolog of a protein identified in Drosophila as a suppressor of malignant transformation of neuroblasts and ganglion mother cells in the optic centers of the brain. This gene product is localized to condensed chromosomes in mitotic cells. Overexpression of this gene in a glioma cell line results in improper nuclear segregation and cytokinesis producing multinucleated cells. Alternatively spliced transcript variants encoding different isoforms have been identified.[7]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000185513 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000035576 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Koga H, Matsui S, Hirota T, Takebayashi S, Okumura K, Saya H (Sep 1999). "A human homolog of Drosophila lethal(3)malignant brain tumor (l(3)mbt) protein associates with condensed mitotic chromosomes". Oncogene. 18 (26): 3799–809. doi:10.1038/sj.onc.1202732. PMID 10445843. S2CID 8186230.
  6. ^ Trojer P, Li G, Sims RJ III, Vaquero A, Kalakonda N, Boccuni P, Lee D, Erdjument-Bromage H, Tempst P, Nimer SD, Wang YH, Reinberg D (Jun 2007). "L3MBTL1, a histone-methylation-dependent chromatin lock". Cell. 129 (5): 915–28. doi:10.1016/j.cell.2007.03.048. PMID 17540172. S2CID 16425537.
  7. ^ a b "Entrez Gene: L3MBTL l(3)mbt-like (Drosophila)".

Further reading

  • Overview of all the structural information available in the PDB for UniProt: Q9Y468 (Lethal(3)malignant brain tumor-like protein 1) at the PDBe-KB.


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