en KCNV1

KCNV1
Identifiers
Aliases	KCNV1, HNKA, KCNB3, KV2.3, KV8.1, potassium voltage-gated channel modifier subfamily V member 1
External IDs	OMIM: 608164; MGI: 1914748; HomoloGene: 22811; GeneCards: KCNV1; OMA:KCNV1 - orthologs
Gene location (Human)
Chr.	Chromosome 8 (human)
End	109,975,771 bp
Gene location (Mouse)
Chr.	Chromosome 15 (mouse)
End	44,978,316 bp
RNA expression pattern
	Top expressed in
	buccal mucosa cell; ; prefrontal cortex; ; endothelial cell; ; dorsolateral prefrontal cortex; ; Brodmann area 9; ; superior frontal gyrus; ; right frontal lobe; ; Brodmann area 23; ; Brodmann area 46; ; cingulate gyrus;
	Top expressed in
	lumbar spinal ganglion; ; prefrontal cortex; ; primary motor cortex; ; superior frontal gyrus; ; primary visual cortex; ; piriform cortex; ; dentate gyrus of hippocampal formation granule cell; ; Temporal Lobe; ; hippocampus proper; ; cingulate gyrus;
	More reference expression data
	n/a
Gene ontology
Molecular function	ion channel inhibitor activity; potassium channel regulator activity; ion channel activity; voltage-gated ion channel activity; potassium channel activity; voltage-gated potassium channel activity;
Cellular component	plasma membrane; membrane; voltage-gated potassium channel complex; integral component of membrane; integral component of plasma membrane;
Biological process	ion transport; transmembrane transport; potassium ion transport; protein homooligomerization; regulation of ion transmembrane transport; potassium ion transmembrane transport;
	Sources:Amigo / QuickGO
Orthologs
	27012
	67498
	ENSG00000164794
	ENSMUSG00000022342
	Q6PIU1
	Q8BZN2
	NM_014379
	NM_026200
	NP_055194
	NP_080476
	Wikidata
View/Edit Human	View/Edit Mouse

Potassium voltage-gated channel subfamily V member 1 is a protein that in humans is encoded by the KCNV1 gene.^[5]^[6] The protein encoded by this gene is a voltage-gated potassium channel subunit.^[5]^[6]

Common variations in the KCNV1 gene have been associated with schizophrenia.^[7]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000164794 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000022342 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b Hugnot JP, Salinas M, Lesage F, Guillemare E, de Weille J, Heurteaux C, Mattei MG, Lazdunski M (Aug 1996). "Kv8.1, a new neuronal potassium channel subunit with specific inhibitory properties towards Shab and Shaw channels". EMBO J. 15 (13): 3322–31. doi:10.1002/j.1460-2075.1996.tb00697.x. PMC 451895. PMID 8670833.
^ ^a ^b Gutman GA, Chandy KG, Grissmer S, Lazdunski M, McKinnon D, Pardo LA, Robertson GA, Rudy B, Sanguinetti MC, Stuhmer W, Wang X (Dec 2005). "International Union of Pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels". Pharmacol Rev. 57 (4): 473–508. doi:10.1124/pr.57.4.10. PMID 16382104. S2CID 219195192.
^ Schizophrenia Working Group of the Psychiatric Genomics Consortium (2014-07-24). "Biological insights from 108 schizophrenia-associated genetic loci". Nature. 511 (7510): 421–427. Bibcode:2014Natur.511..421S. doi:10.1038/nature13595. ISSN 1476-4687. PMC 4112379. PMID 25056061.

External links

Kv8.1+Potassium+Channel at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
KCNV1+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

This membrane protein–related article is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000164794 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000022342 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8670833-5] Hugnot JP, Salinas M, Lesage F, Guillemare E, de Weille J, Heurteaux C, Mattei MG, Lazdunski M (Aug 1996). "Kv8.1, a new neuronal potassium channel subunit with specific inhibitory properties towards Shab and Shaw channels". EMBO J. 15 (13): 3322–31. doi:10.1002/j.1460-2075.1996.tb00697.x. PMC 451895. PMID 8670833.

[pmid16382104-6] Gutman GA, Chandy KG, Grissmer S, Lazdunski M, McKinnon D, Pardo LA, Robertson GA, Rudy B, Sanguinetti MC, Stuhmer W, Wang X (Dec 2005). "International Union of Pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels". Pharmacol Rev. 57 (4): 473–508. doi:10.1124/pr.57.4.10. PMID 16382104. S2CID 219195192.

[7] Schizophrenia Working Group of the Psychiatric Genomics Consortium (2014-07-24). "Biological insights from 108 schizophrenia-associated genetic loci". Nature. 511 (7510): 421–427. Bibcode:2014Natur.511..421S. doi:10.1038/nature13595. ISSN 1476-4687. PMC 4112379. PMID 25056061.

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KCNV1

References

Further reading

External links