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brain area involved in behavioral activation and motivated behavior. Hypolocomotion, also known as locomotor hypoactivity, hypoactivity, and decreased locomotor...

does not produce hyperlocomotion in rodents, and instead can produce hypolocomotion at high doses that is independent of the serotonin 5-HT2C receptor....

a minor vespryn protein component specific to this species, causes hypolocomotion and hyperalgesia in experimental mice. It is believed that it contributes...

persisting antidepressant- and anxiolytic-like effects as well as acute hypolocomotion in animals. In humans, ketanserin blocked psilocybin's hallucinogenic...

changes, sensorimotor alterations, analgesia, hypothermia, bradypnea, hypolocomotion, convulsions, and hyperreflexia. These effects can be variably reversed...

also been found to reverse meta-chlorophenylpiperazine (mCPP)-induced hypolocomotion and to attenuate haloperidol-induced catalepsy. The drug was under development...

another study, it produced a biphasic effect at high doses, with initial hypolocomotion followed after a few hours by weak locomotor stimulation. 7-AB is a...

test. In addition to its psychedelic-like effects, 4-HO-NET produces hypolocomotion and hypothermia in rodents. 4-HO-NET was first described in the scientific...

The behavioral and physiological features of this syndrome include hypolocomotion, head twitch, forepaw treading, tremors, hindlimb abduction, flat body...

rodents as well. In addition, SSRIs have been found to acutely induce hypolocomotion, which can be reversed by SB-242084. SB-242084 was under development...

hyperlocomotion in rodents as well as to dose-dependently reverse the hypolocomotion induced by the monoamine depleting agent tetrabenazine in rodents. The...

and fluoxetine. The drug has also been found to block mCPP-induced hypolocomotion. Both SB-221284 and the selective serotonin 5-HT2C receptor antagonist...

7MDTIQ shows different pharmacological effects, for instance producing hypolocomotion instead of hyperlocomotion. The chemical synthesis of 3Me6,7MDTIQ has...

a silent antagonist of the serotonin 5-HT2C receptor. It blocks the hypolocomotion and hypophagia induced by the serotonin 5-HT2C receptor agonist...

test. In addition to its psychedelic-like effects, 4-HO-NPT produces hypolocomotion and hypothermia in rodents. 4-HO-NPT was first described in the scientific...

behavioral and physiological effects in rats, including pupil dilation and hypolocomotion among others, but was 6-fold less potent than DOM in this species. It...

cause this response even at very high doses. 4-HO-NBnT also produces hypolocomotion and hypothermia in rodents. 4-HO-NBnT, also known as 4-hydroxy-N-benzyltryptamine...

However, whereas tryptamine was unable to produce hypolocomotion without an MAOI, CE-T showed hypolocomotion regardless of whether the MAOI clorgiline was...

Other effects of DOM in rodents include hyperlocomotion at lower doses, hypolocomotion at higher doses, and hypothermia at high doses. In contrast to amphetamines...

rodents. It produces effects in rodents including central depression, hypolocomotion, catalepsy, sedation, ataxia, analgesia, anxiolysis, anticonvulsant...

interactions of ropinirole have been described. Ropinirole produces marked hypolocomotion at lower doses (1–50 mg/kg i.p.) and causes hyperlocomotion at higher...

rodent drug discrimination tests. 4-AcO-DMT produces effects such as hypolocomotion and hypothermia in rodents as with psilocin as well. There are no clinical...

rodents, but is much less potent than other 2C drugs. It also produces hypolocomotion at high doses similarly to other psychedelics, but failed to affect...

no head-twitch response (a behavioral proxy of psychedelic effects), hypolocomotion, or hypothermia, in contrast to psilocin and norpsilocin, but similarly...

WAY-100635. Besides psychedelic-like effects, 5-MeO-DiPT also produces hypolocomotion and hypothermia in rodents and potentiates the forepaw treading induced...

receptor over the serotonin 5-HT2A receptor. The drug reverses the hypolocomotion induced by the serotonin 5-HT2C receptor agonist meta-chlorophenylpiperazine...

TCB-2 has been found to produce hyperlocomotion at lower doses and hypolocomotion at higher doses in rodents. The drug produces rapid antidepressant-...

by hypolocomotion at the highest assessed dose. This is in contrast to many other psychedelic tryptamines, which tend to produce only hypolocomotion. 5-MeO-DMT...

sensitivity to amphetamine in TAAR1-OE mice with amphetamine-induced hypolocomotion, and had no effect on locomotion in the control group [44]. Interestingly...

antidepressant-like effects in rodents. The drug dose-dependently produces hypolocomotion in rodents similarly to many other serotonergic psychedelics. Likewise...

animals including antiparkinsonian-like effects, stereotypy, hypothermia, hypolocomotion at lower doses and hyperlocomotion at higher doses, and emesis. In addition...

activity and also has weaker vasoconstrictor effects. DPDA produces hypolocomotion across a wide range of doses in rodents. It modestly reduces climbing...

receptor agonist in vivo. LEK-8829 produces effects in animals including hypolocomotion, sedation, catalepsy, antipsychotic-like effects, antiparkinsonian-like...

dopaminergic neurotoxin MPTP, S32504 reversed hypolocomotion. Conversely, in untreated rodents, S32504 produced hypolocomotion over a wide range of doses and did...

instead inducing only serotonin 5-HT1A receptor-mediated hypothermia and hypolocomotion. 5-MT is only briefly mentioned in several places in Alexander Shulgin's...

produce hyperlocomotion at lower doses in rodents. All 2C drugs produce hypolocomotion at higher doses in rodents. 2C drugs, including 2C-C, 2C-D, 2C-E, and...

no effect on locomotor activity in rodents at low doses but produced hypolocomotion at high doses. O-Phenyl-3-iodotyramine Scanlan T, Suchland K, Hart M...

On the other hand, 5-bromo-DMT produced antidepressant-like effects, hypolocomotion or sedative-like effects, and hypothermia in rodents. Moreover, 5-bromo-DMT...

it does induce serotonin 5-HT1A receptor-mediated hypothermia and hypolocomotion. Earlier reports had stated that 5-MeO-NMT and its N-demethylated analogue...

subsequent study found that the highest assessed dose produced significant hypolocomotion and that the drug also reduced fentanyl self-administration. Noribogainalog...

psychedelic effects, in rodents, albeit relatively weakly. It also produces hypolocomotion and hypothermia in rodents. In combination with the serotonin 5-HT1A...

20-fold lower potency than DMT in the rat fundus strip. The drug produces hypolocomotion in rodents. In addition, it induces the head-twitch response, a behavioral...

has been found to produce effects in animals including hypothermia, hypolocomotion, antidepressant-like effects, anxiolytic-like effects, anti-obsessional-like...

receptor antagonists sulpiride, haloperidol, and pimozide. It reverses the hypolocomotion induced by the dopamine depleting agent reserpine in rodents. The drug...

A1 and A2A receptors. It produces sedative and hypnotic effects and hypolocomotion in animals. The drug is orally active and crosses the blood–brain barrier...

at the serotonin 5-HT2A receptor. The drug has been found to produce hypolocomotion and sedative-like effects, antidepressant-like effects, anxiolytic-like...

effects. In addition to its psychedelic-like effects, BOD produces hypolocomotion and conditioned place preference (CPP) in rodents. Conversely, it does...

than at synaptic receptors. It produces effects in animals including hypolocomotion and hyperlocomotion (dependent on dose), anxiogenic effects, pronociceptive...

persisting antidepressant- and anxiolytic-like effects as well as acute hypolocomotion of the serotonergic psychedelic and non-selective serotonin receptor...

5-hydroxytryptophan (5-HTP) in rodents. In addition, it produces tremors, hypolocomotion, motor incoordination, and vasodilation in rodents. NcPT has also been...

psychostimulant-like effects as well as misuse potential. Instead, 5-MeO-AMT produces hypolocomotion. 5-MeO-AMT is known to produce sympathomimetic effects, but these effects...

(PCP). In addition, whereas meta-chlorophenylpiperazine (mCPP) produces hypolocomotion by itself, the combination of mCPP with LY-53857 results in mCPP producing...

dramatically reduces dopamine release in the caudate nucleus, produces hypolocomotion, and strongly suppresses prolactin secretion in rodents. No effects...

response (a behavioral proxy of psychedelic effects), hypothermia, and hypolocomotion. Its median effective dose (ED50) for producing the head-twitch response...

active in the conditioned avoidance test and produces dose-dependent hypolocomotion in rodents similarly to psychedelic tryptamines. Analogues of DHT include...

favorable pharmacokinetic properties in preclinical research. It produced hypolocomotion in a serotonin 5-HT2C receptor-dependent but not serotonin 5-HT2A receptor-dependent...

this effect is blocked by volinanserin. In addition, DiPT produces hypolocomotion. The drug also produces convulsions at high doses in rodents. The unique...

and was unlikely to be tested in humans. It has been found to produce hypolocomotion in rodents. Conversely, pyr-T (3 mg/kg) failed to acutely produce the...

subsequent study however, it produced hyperlocomotion at lower doses and hypolocomotion at higher doses. The drug has shown pro-motivational effects in rodents...

They have also been found to produce hyperlocomotion at low doses and hypolocomotion at high doses in rodents. Unlike most other serotonergic psychedelics...

discrimination tests, at least at the assessed doses. The drug also produces hypolocomotion and hypothermia in rodents. Analogues of 5-fluoro-DMT include dimethyltryptamine...

5-HT1D receptor ligand. In rodents, pellotine dose-dependently produces hypolocomotion, inhibits REM sleep, and promotes sleep fragmentation. The hypnotic...

measure of psychostimulant-like effect, in normal rats, and reverses hypolocomotion in reserpine-treated rats. These effects are reversed by the dopamine...

produce sedation, hypnotic effects, motor impairment, muscle relaxation, hypolocomotion, anxiolytic-like effects, antidepressant-like effects, analgesic effects...

anti-allergy effects, antimigraine effects, sedative and hypnotic effects, and hypolocomotion in animals. In terms of chemical structure, it is a cyclized pyrrolidine...

hyperlocomotion in rodents and instead dose-dependently produces only hypolocomotion. On the other hand, it does similarly produce hypothermia at higher...

antidepressant-like effects in rodents. It also dose-dependently produces hypolocomotion in rodents. At higher doses, 4-F-5-MeO-pyr-T induces a pronounced serotonin...

intermediate potency among halogenated derivatives. In addition, it produces hypolocomotion and hypothermia, effects that appear to be mediated through serotonin...

effect in Mus musculus, Rattus norvegicus, and Homo sapiens. It reduces hypolocomotion caused by anxiety, which was psychopharmacologically induced with mCPP...

effects of DOAM in rodents include hyperlocomotion at lower doses, hypolocomotion at higher doses, and hypothermia at higher doses. As the 4-alkyl chain...

catecholamines. 1-Ethyl-β-carboline produces central depression or hypolocomotion and hypotension in rodents. It is a weak reversible inhibitor of monoamine...

induced by 5-MeO-EiPT in rodents. The drug also produces hypothermia and hypolocomotion in rodents. Analogues of 5-MeO-EiPT include ethylisopropyltryptamine...

effects of DOBU in rodents include hyperlocomotion at lower doses, hypolocomotion at higher doses, and hypothermia at higher doses. DOBU crosses the blood–brain...

receptor supersensitivity with dopamine depletion. Romergoline produces hypolocomotion in rodents and monkeys, inhibits apomorphine-induced climbing behavior...

receptors over the D2-like receptors. It has been found to produce hypolocomotion, inhibit dizocilpine (MK-801)-induced hyperlocomotion, inhibit apomorphine-induced...

certain serotonin 5-HT1 receptors. Unlike psilocin, which produced hypolocomotion mediated by serotonin 5-HT1A receptor activation, 1-methylpsilocin showed...

agonist and results show that YM348 can induce penile erections and hypolocomotion (induced at a high dose) in rats, as did other 5-HT2C receptor agonists...