Hyperkatifeia

Hyperkatifeia is defined as hypersensitivity to emotional distress in the context of opioid abuse.[1]

Hyperkatifeia and opioid-induced hyperalgesia can be seen with long-term use of illicit street opioids e.g. heroin, and prescription opioids e.g. hydrocodone and oxycodone during withdrawal.[2]

References

  1. ^ Shurman J, Koob GF, Gutstein HB (2010). "Opioids, pain, the brain, and hyperkatifeia: a framework for the rational use of opioids for pain". Pain Med. 11 (7): 1092–8. doi:10.1111/j.1526-4637.2010.00881.x. PMC 2907890. PMID 20545871.
  2. ^ Koob, George F. (2021). "Drug Addiction: Hyperkatifeia/Negative Reinforcement as a Framework for Medications Development". Pharmacological Reviews. 73 (1): 163–201. doi:10.1124/pharmrev.120.000083. PMC 7770492. PMID 33318153.


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