Hi1a

Hi1a is a peptide from the venom of the Darling Downs funnel-web spider (Hadronyche infensa) which researchers have found, in studies done on mice, to be an acid-sensing ion channel 1a (ASIC1a) inhibitor.[1][2][3] It has cardioprotective properties - preventing heart tissue from degradation during a heart attack[2][4] and also has a highly neuroprotective effect in case of stroke.[5][6] It is being studied for its potential use for acute ischemic events by preventing cell death.[1][3][7]

References

  1. ^ a b Duggan, Nisharnthi M.; Saez, Natalie J.; Clayton, Daniel; Budusan, Elena; Watson, Emma E.; Tucker, Isaac J.; Rash, Lachlan D.; King, Glenn F.; Payne, Richard J. (November 5, 2021). "Total Synthesis of the Spider-Venom Peptide Hi1a". Organic Letters. 23 (21): 8375–8379. doi:10.1021/acs.orglett.1c03112. PMID 34632783 – via CrossRef.
  2. ^ a b Redd, Meredith A.; Yoshikawa, Yusuke; Khan, Nemat; Waqar, Maleeha; Saez, Natalie J.; Outhwaite, Jennifer E.; Russell, Jake S.; Hanna, Amy D.; Chiu, Han S.; Er, Sing Yan; Butcher, Neville J.; Mardon, Karine; Fraser, John F.; Smythe, Mark L.; Rash, Lachlan D.; Thomas, Walter G.; King, Glenn F.; Reichelt, Melissa E.; Palpant, Nathan J. (2024). "Acid-sensing ion channel 1a blockade reduces myocardial injury in rodent models of myocardial infarction". European Heart Journal. 45 (17): 1571–1574. doi:10.1093/eurheartj/ehad793. hdl:10072/432411.
  3. ^ a b "Spider venom heart drug moves to clinical trials". UQ News.
  4. ^ Cooke, Emily (October 16, 2024). "Drug inspired by spider venom aims to reverse heart attack damage". livescience.com.
  5. ^ Chassagnon, Irène R.; McCarthy, Claudia A.; Chin, Yanni K.-Y.; Pineda, Sandy S.; Keramidas, Angelo; Mobli, Mehdi; Pham, Vi; De Silva, T. Michael; Lynch, Joseph W.; Widdop, Robert E.; Rash, Lachlan D.; King, Glenn F. (April 4, 2017). "Potent neuroprotection after stroke afforded by a double-knot spider-venom peptide that inhibits acid-sensing ion channel 1a". Proceedings of the National Academy of Sciences. 114 (14): 3750–3755. Bibcode:2017PNAS..114.3750C. doi:10.1073/pnas.1614728114. PMC 5389327. PMID 28320941.
  6. ^ "Hi1a demonstrates neuroprotective activity in EAE mice | BioWorld". www.bioworld.com.
  7. ^ "Funnel-web spider venom may provide a new drug for heart attacks". Australian Government Department of Health and Aged Care. 13 December 2022. Retrieved 22 January 2025.


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