Ham test

Ham test

The Ham test is a blood test used in the diagnosis of paroxysmal nocturnal hemoglobinuria (PNH). Patient red blood cells (RBCs) are placed in mild acid; a positive result (increased RBC fragility) indicates PNH or congenital dyserythropoietic anemia.[1][2] This is now an obsolete test for diagnosing PNH due to its low sensitivity and specificity.[3]

As one fourth of PNH cases progress to aplastic anemia, Ham's test is occasionally positive in AA.[4]

References

  1. ^ Ham, Thomas H. (1937). "Chronic Hemolytic Anemia with Paroxysmal Nocturnal Hemoglobinuria". New England Journal of Medicine. 217 (23): 915–7. doi:10.1056/NEJM193712022172307.
  2. ^ MedlinePlus Encyclopedia: Ham test
  3. ^ "Paroxysmal Nocturnal Hemoglobinuria - PNH". ARUP.
  4. ^ Ferri, Fred F. (2015). Ferri's Clinical Advisor 2016 E-Book: 5 Books in 1. Elsevier Health Sciences. p. 140. ISBN 9780323378222.


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