HT1080

HT1080 is a fibrosarcoma cell line which has been used extensively in biomedical research. The cell line was created from tissue taken in a biopsy of a fibrosarcoma present in a 35-year-old human male.[1] The patient who supplied the sample had not undergone radio or chemotherapy, making it less likely that unwanted mutations were introduced into the cell line.

The cell line carries an IDH1 mutation and an activated N-ras oncogene.[2]

References

  1. ^ Rasheed, Suraiya; Nelson-Rees, Walter A.; Toth, Eva M.; Arnstein, Paul; Gardner, Murray B. (1974). "Characterization of a newly derived human sarcoma cell line (HT-1080)". Cancer. 33 (4): 1027–33. doi:10.1002/1097-0142(197404)33:4<1027::AID-CNCR2820330419>3.0.CO;2-Z. PMID 4132053.
  2. ^ Benedict, WF; et al. (August 1984). "Tumorigenicity of human HT1080 fibrosarcoma X normal fibroblast hybrids: chromosome dosage dependency". Cancer Research. 44 (8): 3471–3479. PMID 6744274.
Stub icon

This oncology article is a stub. You can help Wikipedia by adding missing information.

Content Disclaimer

Informasi ini disarikan dari Wikipedia dan disajikan kembali untuk tujuan edukasi. Konten tersedia di bawah lisensi CC BY-SA 3.0. Kami tidak bertanggung jawab atas ketidakakuratan data yang bersumber dari kontribusi publik tersebut.

  1. The information displayed on this website is sourced in part or in whole from Wikipedia and has been adapted for the purpose of restating it. We strive to provide accurate and relevant information, however:
  2. There is no guarantee of absolute accuracy. Wikipedia is an open, collaborative project that can be edited by anyone, so information is subject to change.
  3. It is not intended to constitute professional advice. The content displayed is for informational and educational purposes only. For important decisions (e.g., medical, legal, or financial), please consult a professional.
  4. Content copyright. Wikipedia is licensed under the Creative Commons Attribution-ShareAlike License (CC BY-SA). This means that content may be reused with appropriate attribution and shared under a similar license.
  5. Responsible use. Any risk arising from the use of information from this website is entirely the responsibility of the user.