Glesatinib

Glesatinib
Clinical data
Routes of
administration		By mouth
ATC code
  • None
Legal status
Legal status
  • Investigational
Identifiers
  • N-[(3-Fluoro-4-{[2-(5-{[(2-methoxyethyl)amino]methyl}-2-pyridinyl)thieno[3,2-b]pyridin-7-yl]oxy}phenyl)carbamothioyl]-2-(4-fluorophenyl)acetamide
CAS Number
PubChem CID
ChemSpider
UNII
KEGG
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC31H27F2N5O3S2
Molar mass619.71 g·mol−1
3D model (JSmol)
  • COCCNCc1ccc(nc1)c2cc3c(s2)c(ccn3)Oc4ccc(cc4F)NC(=S)NC(=O)Cc5ccc(cc5)F
  • InChI=1S/C31H27F2N5O3S2/c1-40-13-12-34-17-20-4-8-24(36-18-20)28-16-25-30(43-28)27(10-11-35-25)41-26-9-7-22(15-23(26)33)37-31(42)38-29(39)14-19-2-5-21(32)6-3-19/h2-11,15-16,18,34H,12-14,17H2,1H3,(H2,37,38,39,42)
  • Key:YRCHYHRCBXNYNU-UHFFFAOYSA-N

Glesatinib (MGCD265) is an experimental anti-cancer drug.[1][2]

It is in phase 2 clinical trials for non-small cell lung cancer (NSCLC).[3]

It is a spectrum selective tyrosine[1] kinase inhibitor "for the treatment of non-small cell lung cancer (NSCLC) patients with genetic alterations of MET".[4]

See also

References

  1. ^ a b "Glesatinib". NCI Dictionaries. National Cancer Institute at the National Institutes of Health. U.S. Department of Health and Human Services. Archived from the original on 2017-01-16. Retrieved 2017-01-15.
  2. ^ Cui Q, Cai CY, Gao HL, Ren L, Ji N, Gupta P, Yang Y, Shukla S, Ambudkar SV, Yang DH, Chen ZS (2019). "Glesatinib, a c-MET/SMO Dual Inhibitor, Antagonizes P-glycoprotein Mediated Multidrug Resistance in Cancer Cells". Frontiers in Oncology. 9 313. doi:10.3389/fonc.2019.00313. PMC 6494935. PMID 31106148.
  3. ^ Clinical trial number NCT02954991 for "Phase 2 Study of Glesatinib, Sitravatinib or Mocetinostat in Combination With Nivolumab in Non-Small Cell Lung Cancer " at ClinicalTrials.gov
  4. ^ "Mirati Therapeutics Provides Update On Glesatinib And Sitravatinib Clinical Trials And Pipeline Programs". PipelineReview.com. January 2017.


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