GZMB

GZMB
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesGZMB, CCPI, CGL-1, CGL1, CSP-B, CSPB, CTLA1, CTSGL1, HLP, SECT, granzyme B, C11
External IDsOMIM: 123910; MGI: 109267; HomoloGene: 108184; GeneCards: GZMB; OMA:GZMB - orthologs
Orthologs
SpeciesHumanMouse
Entrez

3002

14939

Ensembl

ENSG00000100453

ENSMUSG00000015437

UniProt

P10144

P04187

RefSeq (mRNA)

NM_004131
NM_001346011

NM_013542

RefSeq (protein)

NP_001332940
NP_004122

NP_038570

Location (UCSC)Chr 14: 24.63 – 24.63 MbChr 14: 56.5 – 56.5 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Granzyme B is a serine protease that in humans is encoded by the GZMB gene.[5] Granzyme B is expressed by cytotoxic T lymphocytes (CTL) and natural killer (NK) cells.

CTL and NK cells share the remarkable ability to recognize specific infected target cells. They are thought to protect their host by inducing apoptosis of cells that bear on their surface 'nonself' antigens, usually peptides or proteins resulting from infection by intracellular pathogens. The protein encoded by this gene is crucial for the rapid induction of target cell apoptosis by CTL in cell-mediated immune response.[6]

See also

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000100453 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000015437 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Dahl CA, Bach FH, Chan W, Huebner K, Russo G, Croce CM, Herfurth T, Cairns JS (May 1990). "Isolation of a cDNA clone encoding a novel form of granzyme B from human NK cells and mapping to chromosome 14". Hum Genet. 84 (5): 465–70. doi:10.1007/bf00195821. PMID 2323780. S2CID 22245529.
  6. ^ "Entrez Gene: GZMB granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)".

Further reading

Stub icon

This article on a gene on human chromosome 14 is a stub. You can help Wikipedia by adding missing information.

Content Disclaimer

Informasi ini disarikan dari Wikipedia dan disajikan kembali untuk tujuan edukasi. Konten tersedia di bawah lisensi CC BY-SA 3.0. Kami tidak bertanggung jawab atas ketidakakuratan data yang bersumber dari kontribusi publik tersebut.

  1. The information displayed on this website is sourced in part or in whole from Wikipedia and has been adapted for the purpose of restating it. We strive to provide accurate and relevant information, however:
  2. There is no guarantee of absolute accuracy. Wikipedia is an open, collaborative project that can be edited by anyone, so information is subject to change.
  3. It is not intended to constitute professional advice. The content displayed is for informational and educational purposes only. For important decisions (e.g., medical, legal, or financial), please consult a professional.
  4. Content copyright. Wikipedia is licensed under the Creative Commons Attribution-ShareAlike License (CC BY-SA). This means that content may be reused with appropriate attribution and shared under a similar license.
  5. Responsible use. Any risk arising from the use of information from this website is entirely the responsibility of the user.