GLYCAM1

GLYCAM1
Identifiers
AliasesGLYCAM1, glycosylation dependent cell adhesion molecule 1 (pseudogene)
External IDsMGI: 95759; GeneCards: GLYCAM1; OMA:GLYCAM1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez

644076

14663

Ensembl

ENSG00000257780

ENSMUSG00000022491

UniProt

n
a

Q02596

RefSeq (mRNA)

n/a

NM_001289587
NM_008134

RefSeq (protein)

n/a

NP_001276516
NP_032160

Location (UCSC)Chr 12: 54.61 – 54.61 MbChr 15: 103.47 – 103.47 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Glycosylation-dependent cell adhesion molecule-1 is a protein that is encoded by the GLYCAM1 gene. In humans, GLYCAM1 is a pseudogene while in many other mammals including mouse, it is a protein coding gene.

GLYCAM1 is a proteoglycan ligand expressed on cells of the high endothelial venules in lymphoid tissues. It is the ligand for the receptor L-selectin allowing for naive lymphocytes to exit the bloodstream into lymphoid tissues.[5][6] GLYCAM1 binds to L-selectin by presenting one or more O-linked carbohydrates to the lectin domain of the leukocyte cell surface selectin.[citation needed] Data suggests that GLYCAM1 is a hormone-regulated milk protein that is part of the milk mucin complex.[7]

GlyCAM-1 is expressed exclusively on high endothelial venules. It is unclear how GlyCAM-1 is attached to the membrane as it lacks a transmembrane region.[5]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000257780 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000022491 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b Imhof BA, Dunon D (1995). Leukocyte Migration and Adhesion. Advances in Immunology. Vol. 58. pp. 345–416. doi:10.1016/s0065-2776(08)60623-9. ISBN 978-0-12-022458-6. PMID 7537936.
  6. ^ Brustein M, Kraal G, Mebius RE, Watson SR (November 1992). "Identification of a soluble form of a ligand for the lymphocyte homing receptor". The Journal of Experimental Medicine. 176 (5): 1415–1419. doi:10.1084/jem.176.5.1415. PMC 2119429. PMID 1383387.
  7. ^ Dowbenko D, Kikuta A, Fennie C, Gillett N, Lasky LA (August 1993). "Glycosylation-dependent cell adhesion molecule 1 (GlyCAM 1) mucin is expressed by lactating mammary gland epithelial cells and is present in milk". The Journal of Clinical Investigation. 92 (2): 952–960. doi:10.1172/JCI116671. PMC 294935. PMID 8349827.
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