EGb-761

EGb-761
Clinical data
Trade namesGingogink; Tebonin; Tramisal
Other namesGBE 761; Ginkgo biloba special extract; EGb761
Routes of
administration		Oral
ATC code
Legal status
Legal status
Pharmacokinetic data
BioavailabilityNot fully established
MetabolismNot fully established
Identifiers
CAS Number

EGb-761 (also written EGb 761, branded Gingogink, Tebonin, Tramisal) is a standardised extract of the leaves of the tree Ginkgo biloba, containing flavonoid glycosides and terpene lactones, and used in some countries for symptoms such as cognitive decline, peripheral circulatory disorders, tinnitus and vertigo.[1]

Mechanism of action

The pharmacological effects of EGb-761 are attributed to multiple mechanisms: antioxidant and free-radical-scavenging actions, modulation of micro-circulation (hemorheological effects), protective effects on mitochondrial function, and possible effects on neuronal signalling and excitotoxicity.[2]

In relation to auditory disorders and tinnitus, it has been proposed that EGb-761 may help stabilize inner-ear microcirculation, reduce oxidative stress, and modulate neuro-auditory pathways.[3]

A systematic review concluded that "there is evidence of efficacy for the standardised extract, EGb 761, ... in the treatment of tinnitus".[4]

See also

References

  1. ^ "Assessment report on Ginkgo biloba L., folium – European Medicines Agency" (PDF). European Medicines Agency. 2014-01-28. Retrieved 2025-11-12.
  2. ^ Ren C, Ji YQ, Liu H, Wang Z, Wang JH, Zhang CY, et al. (2019). "Effects of Ginkgo biloba extract EGb 761® on neural systems: antioxidant, mitochondrial, neuro-signalling and circulatory mechanisms". Neural Regeneration Research. 14 (7). U.S. National Library of Medicine: 1152–1157. doi:10.4103/1673-5374.251191. PMC 6425836. PMID 30804240.
  3. ^ von Boetticher A (2011). "Ginkgo biloba extract in the treatment of tinnitus: a systematic review". Neuropsychiatric Disease and Treatment. 7: 441–447. doi:10.2147/NDT.S22793. PMC 3157487. PMID 21857784.
  4. ^ von Boetticher A (2011). "Ginkgo biloba extract in the treatment of tinnitus: a systematic review". Neuropsychiatric Disease and Treatment. 7: 441–447. doi:10.2147/NDT.S22793. PMC 3157487. PMID 21857784.

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