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EDF1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1X57
Identifiers
Aliases	EDF1, EDF-1, MBF1, CFAP280, endothelial differentiation related factor 1
External IDs	OMIM: 605107; MGI: 1891227; HomoloGene: 2809; GeneCards: EDF1; OMA:EDF1 - orthologs
Gene location (Human)
Chr.	Chromosome 9 (human)
End	136,866,308 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	25,452,094 bp
RNA expression pattern
	Top expressed in
	parotid gland; ; anterior pituitary; ; body of pancreas; ; right lobe of thyroid gland; ; left lobe of thyroid gland; ; mucosa of transverse colon; ; duodenum; ; right hemisphere of cerebellum; ; jejunal mucosa; ; body of stomach;
	Top expressed in
	Paneth cell; ; facial motor nucleus; ; motor neuron; ; fossa; ; endothelial cell of lymphatic vessel; ; condyle; ; transitional epithelium of urinary bladder; ; duodenum; ; right kidney; ; left lobe of liver;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	methyltransferase activity; sequence-specific DNA binding; DNA binding; DNA-binding transcription factor activity; transcription coactivator activity; calmodulin binding; histone acetyltransferase activity; protein binding; RNA binding; TFIID-class transcription factor complex binding;
Cellular component	cytoplasm; transcription factor TFIID complex; intracellular anatomical structure; nucleolus; extracellular exosome; nucleus; cytosol;
Biological process	cell differentiation; regulation of transcription, DNA-templated; transcription, DNA-templated; multicellular organism development; positive regulation of transcription, DNA-templated; regulation of lipid metabolic process; endothelial cell differentiation; positive regulation of DNA binding;
	Sources:Amigo / QuickGO
Orthologs
	8721
	59022
	ENSG00000107223
	ENSMUSG00000015092
	O60869
	Q9JMG1
	NM_153200; NM_001281297; NM_001281298; NM_001281299; NM_003792
	NM_021519
	NP_001268226; NP_001268227; NP_001268228; NP_003783; NP_694880
	NP_067494
	Wikidata
View/Edit Human	View/Edit Mouse

Endothelial differentiation-related factor 1 is a protein that in humans is encoded by the EDF1 gene.^[5]^[6]^[7]

Function

This gene encodes a protein that may regulate endothelial cell differentiation. It has been postulated that the protein functions as a bridging molecule that interconnects regulatory proteins and the basal transcriptional machinery, thereby modulating the transcription of genes involved in endothelial differentiation. This protein has also been found to act as a transcriptional coactivator by interconnecting the general transcription factor TATA element-binding protein (TBP) and gene-specific activators. Two alternatively spliced transcripts which encode distinct proteins have been found for this gene.^[7]

Interactions

EDF1 has been shown to interact with:

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000107223 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000015092 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Dragoni I, Mariotti M, Consalez GG, Soria MR, Maier JA (December 1998). "EDF-1, a novel gene product down-regulated in human endothelial cell differentiation". J Biol Chem. 273 (47): 31119–24. doi:10.1074/jbc.273.47.31119. PMID 9813014.
^ Ballabio E, Mariotti M, De Benedictis L, Maier JA (April 2004). "The dual role of endothelial differentiation-related factor-1 in the cytosol and nucleus: modulation by protein kinase A". Cell Mol Life Sci. 61 (9): 1069–74. doi:10.1007/s00018-004-4016-0. PMC 11146030. PMID 15112053. S2CID 861006.
^ ^a ^b "Entrez Gene: EDF1 endothelial differentiation-related factor 1".
^ ^a ^b ^c Brendel C, Gelman L, Auwerx J (June 2002). "Multiprotein bridging factor-1 (MBF-1) is a cofactor for nuclear receptors that regulate lipid metabolism". Mol. Endocrinol. 16 (6): 1367–77. doi:10.1210/mend.16.6.0843. PMID 12040021.
^ Mariotti M, De Benedictis L, Avon E, Maier JA (August 2000). "Interaction between endothelial differentiation-related factor-1 and calmodulin in vitro and in vivo". J. Biol. Chem. 275 (31): 24047–51. doi:10.1074/jbc.M001928200. PMID 10816571.
^ Kabe Y, Goto M, Shima D, Imai T, Wada T, Morohashi Ki, Shirakawa M, Hirose S, Handa H (November 1999). "The role of human MBF1 as a transcriptional coactivator". J. Biol. Chem. 274 (48): 34196–202. doi:10.1074/jbc.274.48.34196. PMID 10567391.

Li FQ, Ueda H, Hirose S (1994). "Mediators of activation of fushi tarazu gene transcription by BmFTZ-F1". Mol. Cell. Biol. 14 (5): 3013–21. doi:10.1128/mcb.14.5.3013. PMC 358669. PMID 8164657.
Ozaki J, Takemaru KI, Ikegami T, Mishima M, Ueda H, Hirose S, Kabe Y, Handa H, Shirakawa M (1999). "Identification of the core domain and the secondary structure of the transcriptional coactivator MBF1". Genes Cells. 4 (7): 415–24. doi:10.1046/j.1365-2443.1999.00267.x. PMID 10469174. S2CID 17825943.
Mariotti M, De Benedictis L, Avon E, Maier JA (2000). "Interaction between endothelial differentiation-related factor-1 and calmodulin in vitro and in vivo". J. Biol. Chem. 275 (31): 24047–51. doi:10.1074/jbc.M001928200. PMID 10816571.
Brendel C, Gelman L, Auwerx J (2003). "Multiprotein bridging factor-1 (MBF-1) is a cofactor for nuclear receptors that regulate lipid metabolism". Mol. Endocrinol. 16 (6): 1367–77. doi:10.1210/mend.16.6.0843. PMID 12040021.
Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Bolognese F, Pitarque-Martì M, Lo Cicero V, Mantovani R, Maier JA (2006). "Characterization of the human EDF-1 minimal promoter: involvement of NFY and Sp1 in the regulation of basal transcription". Gene. 374: 87–95. doi:10.1016/j.gene.2006.01.030. PMID 16567061.

This article on a gene on human chromosome 9 is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000107223 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000015092 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9813014-5] Dragoni I, Mariotti M, Consalez GG, Soria MR, Maier JA (December 1998). "EDF-1, a novel gene product down-regulated in human endothelial cell differentiation". J Biol Chem. 273 (47): 31119–24. doi:10.1074/jbc.273.47.31119. PMID 9813014.

[pmid15112053-6] Ballabio E, Mariotti M, De Benedictis L, Maier JA (April 2004). "The dual role of endothelial differentiation-related factor-1 in the cytosol and nucleus: modulation by protein kinase A". Cell Mol Life Sci. 61 (9): 1069–74. doi:10.1007/s00018-004-4016-0. PMC 11146030. PMID 15112053. S2CID 861006.

[entrez-7] "Entrez Gene: EDF1 endothelial differentiation-related factor 1".

[pmid12040021-8] Brendel C, Gelman L, Auwerx J (June 2002). "Multiprotein bridging factor-1 (MBF-1) is a cofactor for nuclear receptors that regulate lipid metabolism". Mol. Endocrinol. 16 (6): 1367–77. doi:10.1210/mend.16.6.0843. PMID 12040021.

[pmid10816571-9] Mariotti M, De Benedictis L, Avon E, Maier JA (August 2000). "Interaction between endothelial differentiation-related factor-1 and calmodulin in vitro and in vivo". J. Biol. Chem. 275 (31): 24047–51. doi:10.1074/jbc.M001928200. PMID 10816571.

[pmid10567391-10] Kabe Y, Goto M, Shima D, Imai T, Wada T, Morohashi Ki, Shirakawa M, Hirose S, Handa H (November 1999). "The role of human MBF1 as a transcriptional coactivator". J. Biol. Chem. 274 (48): 34196–202. doi:10.1074/jbc.274.48.34196. PMID 10567391.

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EDF1

Function

Interactions

References

Further reading

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