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In chemistry, dimerization is the process of joining two identical or similar molecular entities by bonds. The resulting bonds can be either strong or...

The telomerization is the linear dimerization of 1,3-dienes with simultaneous addition of a nucleophile in a catalytic reaction. The reaction was independently...

Carbene dimerization is a type of organic reaction in which two carbene or carbenoid precursors react in a formal dimerization to an alkene. This reaction...

(64PPs), their Dewar valence isomers, and the spore photoproduct (SP). Dimerization may proceed via a direct mechanism, in which UV radiation is absorbed...

dimerization (CID) is a biological mechanism in which two proteins bind only in the presence of a certain small molecule, enzyme or other dimerizing agent...

formula BH 3. Because it tends to dimerize or form adducts, borane is very rarely observed. It normally dimerizes to diborane in the absence of other...

produced within the Madagascar periwinkle plant (Catharanthus roseus) whose dimerization produces the anti-cancer drugs vinblastine and vincristine. The precursor...

protein NEMO. Some proteins contain specialized domains to ensure dimerization (dimerization domains) and specificity. The G protein-coupled cannabinoid receptors...

Ribulose-1,5-bisphosphate carboxylase/oxygenase, commonly known by the abbreviations RuBisCo, rubisco, RuBPCase, or RuBPco, is an enzyme (EC 4.1.1.39)...

MAX dimerization protein MGA is a protein that in humans is encoded by the MGA gene. GRCh38: Ensembl release 89: ENSG00000174197 – Ensembl, May 2017 GRCm38:...

compound with the formula C4H4. It is very reactive owing to its tendency to dimerize. Although the parent compound has not been isolated, some substituted derivatives...

DNA binding domain via a “light switch” mechanism. This allows AraC to dimerize and bind the I1 and I2 operators. The AraC-arabinose dimer at this site...

problem with this formulation is "Xe+", which would be a radical and would dimerize or abstract a fluorine atom to give XeF+. Thus, Bartlett discovered that...

colorless liquid. Together with 2,3-dimethyl-2-butene it can be produced by dimerization of propylene. It is a precursor to the commercial fragrance tonalide...

called a "epidermal growth factor receptor (HER) dimerization inhibitor" — it inhibits the dimerization of HER2 with other HER receptors, which prevents...

{red}{\ce {H -}}}{\ce {CH2-CH(Ph)}}{\color {red}{\ce {-CH=CH2}}}} The dimerization of ethylene which gives 1-butene is another example of a hydrovinylation...

alpha helix of a second polypeptide, facilitating dimerization. Leucine zippers are a dimerization motif of the bZIP (Basic-region leucine zipper) class...

binding properties and the leucine zipper that is required to hold together (dimerize) two DNA binding regions. The DNA binding region comprises a number of...

result of the initial dimerization of two cyclobutadienes which preferably forms the syn product, shown below. The further dimerization only produces the...

Jun dimerization protein 2 (JUNDM2) is a protein that in humans is encoded by the JDP2 gene. The Jun dimerization protein is a member of the AP-1 family...

acid catalyst. Dimerization unit converts olefins into higher-octane gasoline blending components. For example, butenes can be dimerized into isooctene...

synthesised but not isolated because it is too reactive, tending to instead dimerize in a Diels-Alder addition. An unstable derivative with 4-alkyl substituents...

chemically induced dimerization applications. FK1012 is a chemical inducer of dimerization (CID) which makes the protein capable of dimerization or oligomerization...

Dimer acids, or dimerized fatty acids, are dicarboxylic acids prepared by dimerizing unsaturated fatty acids obtained from tall oil, usually on clay catalysts...

a strong and unpleasant odor. At room temperature, this cyclic diene dimerizes over the course of hours to give dicyclopentadiene via a Diels–Alder reaction...

FOSL1, and FOSL2. These genes encode leucine zipper proteins that can dimerize with proteins of the JUN family (e.g., c-Jun, JunD), thereby forming the...

unsuccessful. The trityl free radical, Ph3C · , was originally thought to dimerize to form hexaphenylethane. However, an inspection of the NMR spectrum of...

nucleotide-binding domain and a C-terminal dimerization domain joined by a long interdomain α-helix. Each protomer's α-helical dimerization domain wraps around the interdomain...

Look up Dimer, dimer, dimerization, dimeric, or dimerous in Wiktionary, the free dictionary. Dimer may refer to: Dimer (chemistry), a chemical structure...

the chain is clearly an insulator as the chain is broken into dimers (dimerized). However one of the two cases would consist of N / 2 {\displaystyle N/2}...

petrochemical, produced by the catalytic cracking of crude oil or the dimerization of ethylene. Its main uses are in the production of high-octane gasoline...

disulfide bonds, and dimerizes under neutral pH and the influence of protein disulfide isomerase A1 (PDIA1).[citation needed] Dimerized pro-VWF is then transported...

similar physical properties. These compounds arise via the acid catalyzed dimerization of isobutene, a reaction that proceeds via the carbocation (CH3)3C+....

are often very reactive and undergo uncontrollable reactions, notably dimerization and polymerization. Most organic radicals have short lifetimes. A notable...

the primary dimer initiation site (DIS) as it is believed to promote dimerization of the viral genome through formation of a "kissing dimer" intermediate...

aspartame via enzyme-catalysed amination with phenylalanine. Cinnamic acid can dimerize in non-polar solvents resulting in different linear free energy relationships...

compounds are strong electrophiles, but typically too sterically hindered to dimerize. Electron donation from vinyl and aryl groups can lend the C-B bond some...

is involved in retinal, a component of the machinery of vision. The dimerization of alkenes is relevant to the photodamage of DNA, where thymine dimers...

The dimerization partner, RB-like, E2F and multi-vulval class B (DREAM) complex is a protein complex responsible for the regulation of cell cycle-dependent...

cause carbene insertion. Other reactions include rearrangements and dimerizations. A particular carbene's reactivity depends on the substituents, including...

C-terminal dimerization subdomain determines dimerization propensity with other proteins in the NF-κB/Rel protein family. The dimerization subdomain is...

may play a role in the dimerization of non-endogenous RNAs to facilitate the replication of some viruses. Guanine tetrads dimerize through their 5' ends...

aromatic resonance or steric shielding. Acid catalyzes the carbene-like dimerization that some persistent carbenes undergo over the course of days. Persistent...

C181, the last residue of the stalk region in CD8A, is critical for the dimerization, since it forms an inter-subunit disulfide bond. In CD8αα dimers, it...

catalyzed by solid acid catalysts: C2H4 + H2O → CH3CH2OH Ethylene is dimerized by hydrovinylation to give n-butenes using processes licensed by Lummus...

ortho-Carborane is the organoboron compound with the formula C2B10H12. The prefix ortho is derived from the ortho- prefix used to signify that two substituents...

protein structural motif that characterizes one of the largest families of dimerizing transcription factors. The word "basic" does not refer to complexity but...

heating breaks down into P2 molecules. On cooling, these would normally dimerize to give P4 molecules (i.e. white phosphorus) but, in a vacuum, they link...

proposed to explain transmembrane receptors' mechanism of action. Dimerization: The dimerization model suggests that prior to ligand binding, receptors exist...

chlorides undergo a variety of dimerization and cycloaddition reactions. "Simple thiocarbonyl halides all show a tendency to dimerize to some degree, especially...

an antiaromatic one. For this reason, benzocyclobutadiene will readily dimerize or polymerize and it reacts as a dienophile in Diels-Alder reactions. Benzocyclobutadiene...

increases the normal boiling point of the compound. Simple carboxylic acids dimerize by forming hydrogen bonds between molecules. A minor factor affecting boiling...

conserved basic DNA binding domain that binds the E box DNA motif. They dimerize with other HLH containing proteins through an HLH-HLH interaction. There...

(MeO)3Al The molecule is monomeric, unlike H3B and Et3Al, which tend to dimerize. It has a planar BC3 core. Triethylborane was used to ignite the JP-7 fuel...

produced by separation from crude C4 refinery streams and by ethylene dimerization. The former affords a mixture of 1-and 2-butenes, while the latter affords...

tropomyosin binding protease binding transmembrane transporter binding protein dimerization activity cysteine-type endopeptidase activity Cellular component cytoplasm...

presence of acid catalysts. It can also be produced from isobutylene by dimerization using an Amberlyst catalyst to produce a mixture of iso-octenes. Hydrogenation...

or electron-donating substituents. When irradiated by UV-light, alkenes dimerize to give cyclobutanes. Another example is the Schenck ene reaction, in which...

Clematis hirsutissima. Originally isolated in 1792 by M. Heyer, It is the dimerization product of the toxin protoanemonin. One of the likely active agents in...

effects on protein expression. The receptors are generally activated by dimerization and substrate presentation. Receptor tyrosine kinases are part of the...

is the prototypical thioketone. Unlike other thioketones that tend to dimerize to form rings and polymers, thiobenzophenone is quite stable, although...

specifically to 3-hydroxybutanal. It is formally the product of the dimerization of acetaldehyde (CH3CHO). A thick colorless or pale-yellow liquid, it...

Phosphorylation displaces the disordered R domain from positions preventing NBD dimerization and opening. The amino-terminus is part of the lasso motif which anchors...

from a beta-propiolactone ring. A specific example is derived from the dimerization of the ketene of stearic acid. This ketene is generated by pyrolysis...

and ErbB-2 acquire distinct signaling properties dependent upon their dimerization partner". Molecular and Cellular Biology. 18 (9): 5042–5051. doi:10.1128/mcb...

helical sandwich "filling". Along with the DBD, the LBD contributes to the dimerization interface of the receptor and in addition, binds coactivator and corepressor...

to less-substituted cyclopentadiene derivatives, Cp*H is not prone to dimerization. Pentamethylcyclopentadiene is commercially available. It was first prepared...

hydroxide. Another preparation, performed by Liebig in 1838, is the dimerization of benzaldehyde, to benzil, which is transformed to the product by the...

Alder and coworker, the structure was deduced in 1931. The spontaneous dimerization of neat cyclopentadiene at room temperature to form dicyclopentadiene...

has its less stable isomer isocyanogen (cyanogen cyanide), −C≡N+−C≡N. Dimerization of cyanide radicals can also produce a third, even less stable, isomer...

via dephosphorylation of Bcl-2 which allows pro-apoptotic protein Bax to dimerize and initiate programmed cell death. Mebendazole has also been shown to...

ClCF2−CFCl(I) The latter is a precursor to hexafluorobutadiene. Thermal dimerization of chlorotrifluoroethylene gives 1,2-dichloro-1,2,3,3,4,4-hexafluorocyclobutane...

metalloprotein. Upon steroid binding, many kinds of steroid receptors dimerize: two receptor subunits join together to form one functional DNA-binding...

Dimerization of lactaldehyde leads to a mixture of stereoisomeric 1,4-dioxanes....

In enzymology, catechol oxidase (dimerizing) (EC 1.1.3.14) is an enzyme that catalyzes the chemical reaction Four catechol   3 O2 6 H2O 3 O2 6 H2O   Two...

groups, and n is the degree of polymerization. One example is the coupled dimerization and hydroesterification of buta-1,3-diene. This step produces a doubly...

are normally performed in nonpolar media to prevent dimerization.[citation needed] Dimerization of stearic ketene affords alkyl ketene dimers, widely...

acid. Many methods exist for the preparation of cyclobutanes. Alkenes dimerize upon irradiation with UV light, and, in the Norrish-Yang reaction, irradiated...

or two other molecules of butadiene, i.e., dimerization and trimerization respectively. Via dimerization butadiene is converted to 4-vinylcyclohexene...

recruits a second, "F" subunit. The two subunits dimerize on the host cell surface. This dimerization is followed by oligomerization involving three additional...

systematic name of this enzyme class is ATP phosphohydrolase (tubulin-dimerizing). Katanin McNally FJ, Vale RD (1993). "Identification of katanin, an ATPase...

The Breslow catalytic cycle for formaldehyde dimerization and C2-C6 sugar formation...

2-Methylene glutaronitrile is a dimerization product of acrylonitrile and a starting material for di- and triamines, for the biocide...

C4H4O2, and which is sometimes written as (CH2CO)2. It is formed by dimerization of ketene, H2C=C=O. Diketene is a member of the oxetane family. It is...

2005). "Design and synthesis of specific probes for human 5-HT4 receptor dimerization studies" (PDF). Journal of Medicinal Chemistry. 48 (20): 6220–6228. doi:10...

signalling which primes integrins. Moreover, talin proteins are able to dimerize and thus are thought to intervene in the clustering of integrin dimers...

"An antagonist peptide-EPO receptor complex suggests that receptor dimerization is not sufficient for activation". Nature Structural Biology. 5 (11):...

6b05212. PMID 28168876. Cichewicz RH, Kouzi SA, Hamann MT (January 2000). "Dimerization of resveratrol by the grapevine pathogen Botrytis cinerea". Journal of...

viral transcription activator protein Tat. Poly A plays roles both in dimerization and genome packaging since it is necessary for cleavage and polyadenylation...

they keep the polymerase bound to the DNA. 2 τ units (dnaX) which act to dimerize two of the core enzymes (α, ε, and θ subunits). 1 γ unit (also dnaX) which...

produced in the petroleum-refining process of hydrocracking, where it can dimerize to a fifteen ring PAH, trivially named "dicoronylene". Centimeter-long...

57. doi:10.3389/fnins.2014.00057. PMC 4018553. PMID 24834023. OX1–CB1 dimerization was suggested to strongly potentiate orexin receptor signaling, but a...

of 1.40 Å and shortened C-S distances of 1.73 Å. The compound tends to dimerize at room temperature, but the dimer cracks at higher temperature back to...

in vivo clearance by CYP3A4 ALK-001 (d3-vitamin A) Phase 3 Slows the dimerization rate of vitamin A AVP-786 (d6-dextromethorphan) Phase 3 Reduces formation...

ethyl iodide and zinc, but he had not realized that the ethyl radical had dimerized, and thus misidentified the substance. Butane was discovered in crude...

An α-formyl aziridine, reduced with DIBAL from the ester, reversibly dimerizes to an oxazolidine: Hydrazines and hydroxylamines displace carbonyl oxygens...

in the recruitment and activation of the IKKε/TBK-1 complex, inducing dimerization of transcription factors IRF3 and IRF7, which are translocated in the...

conditions, by cycloreversion processes. They are also prone to rapid dimerization, acting as dienes or dienophiles in cycloaddition reactions. Benzo-fused...

forms stable complexes with copper(II) salts. Furoxan may be formed by dimerization of nitrile oxides Olofson, R. A.; Michelman, J. S. (1965). "Furazan"...

sunscreen and as an antimicrobial agent. It is derived from the oxidative dimerization of homogentisic acid. It has been both widely and falsely reported that...

oligomeric state of PSBD. In each E2 homotrimer, two of the three PSBDs dimerize. While two E1 homodimers cooperatively bind dimeric PSBD, the remaining...

form filamentous polymers in a series of assembly steps beginning with dimerization; dimers assemble into tetramers and octamers and eventually, if the current...

behavior of conventional alkenes such as ethylene. Tetrafluoroethylene dimerizes, giving octafluorocyclobutane. Even normal alkenes and dienes add tetrafluoroethylene...

the Nazarov cyclization reaction and in the Rauhut–Currier reaction (dimerization). When appropriately irradiated, they undergo enone–alkene cycloadditions...

domain of the HER family of receptors. Those bound proteins then link (dimerize), activating the receptor. HER2 sends a signal from its intracellular domain...

It contains a bicyclic aromatic chromophore that is attached to the dimerized cyclic peptide core and a thioacetal bridge. It intercalates into DNA...

membrane, it binds to the GR inducing a conformational change and GC-GR dimerization. It was previously thought that this conformational change was necessary...

tyrosine kinase receptors (the VEGFRs) on the cell surface, causing them to dimerize and become activated through transphosphorylation, although to different...

of acid catalysts, ethylene oxide dimerizes to afford dioxane: The reaction mechanism is as follows: The dimerization reaction is unselective. By-products...

interact less, and there is a lower thermodynamic drive for dimerization. In the dimerization reactions, the diene and dienophile were equally electron...

(trans autophosphorylation). The latter often occurs when kinase molecules dimerize. In general, the phosphate groups introduced are gamma phosphates from...

The parent cyclopentadienone is rarely encountered, because it rapidly dimerizes. Many substituted derivatives are known, notably tetraphenylcyclopentadienone...

could still dimerize, indicating protein-protein interactions were sufficient. However, more recent research has clarified that dimerization is not strictly...

(11 January 2025). "Novel archaeal ribosome dimerization factor facilitating unique 30S-30S dimerization". Nucleic Acids Research. 53 (2) gkae1324. doi:10...

ATPase domains of GyrB subunits. Binding of 2 ATP molecules leads to dimerization and, therefore, closing of the gates. Hydrolysis, on the contrary, opens...

of canonical receptor tyrosine kinases such as EGFR leading to their dimerization and subsequent activation of the small GTPase Ras. This then leads to...

alpha-olefins. One class of methods starts with ethylene which is either dimerized or oligomerized. These conversions are respectively effected by the alphabutol...

case R = CH3CH2, R' = CH3, and R" = H. Such reactions are called aldol dimerization. With a mixture of carbonyl precursors, complicated mixtures can occur...

be designed with cells as their basic components. Chemically induced dimerization systems can be used to make logic gates from individual cells. These...

MyD88-dependent and TRIF-dependent pathway. The MyD88-dependent response occurs on dimerization of TLRs, and is used by every TLR except TLR3. Its primary effect is...

bond at the Rβ-position is converted into a C-OH bond. Additionally, a dimerization reaction has been observed in solutions of freebase methcathinone, which...

uncharged/deacylated tRNA which causes a conformational change, resulting in dimerization. Dimerization then causes autophosphorylation and activation. Other stressors...

4-benzoquinone-2-reductase converts it to 1,4-benzoquinone. It tends to dimerize spontaneously by peroxo bridges. Tetrahydroxy-1,4-benzoquinone Philipp...

disproportionation of formaldehyde (to methanol and formate) occurs. The initial dimerization of formaldehyde to give glycolaldehyde (1) occurs via an unknown mechanism...

dissociate from the molecular chaperone complexes and become competent to dimerize, migrate to nucleus, and to bind to specific DNA sequences (estrogen response...

respectively. Naive-to-primed continuum is controlled by reduction of Sox2/Oct4 dimerization on SoxOct DNA elements controlling naive pluripotency. Primed pluripotent...

preventing peptidoglycan elongation and cell wall formation. Dalbavancin also dimerizes and anchors itself in the lipophilic bacterial membrane, thereby increasing...

suggested that KIF1A can dimerize to operate as a two-headed motor and that motility can be regulated by motor dimerization, leading to the conclusion...

is prepared in two steps from chlorotrifluoroethylene. The thermal dimerization gives 1,2-dichloro-1,2,3,3,4,4-hexafluorocyclobutane. Dechlorination...

P, Delic J, Cros S, Paoletti C (1988). "Heterocyclic quinones XIII. Dimerization in the series of 5,8-quinazolinediones: Synthesis and anti tumor effects...

15227/orgsyn.025.0058. R. Huisgen, P. Otto (1968), "The mechanism of dimerization of dimethylketene", J. Am. Chem. Soc., vol. 90, no. 19, pp. 5342–5343...

doi:10.1021/ja00988a057. Kim, Chang G.; Coucouvanis, Dimitri (1993). "Dimerization of the Molybdenum Complex [(SO4)Mo(O)(μ-S)2Mo(O)(SO4)]2- Dianions Stabilized...

genetically modified Saccharomyces cerevisiae yeast strains. Farnesene is then dimerized to isosqualene and then hydrogenated to squalane. In olive squalane manufacturing...

The SH2 domains of the STAT5 proteins are once again used for this dimerization. STAT5 can also form homo-tetramers, usually in concert with the histone...

when refining cocaine from a crude form. Methylecgonine cinnamate can dimerize to the truxillic acid derivative truxilline. Methylecgonine cinnamate is...

prone to dimerization, especially as a free base isolated from plant matter. These dimers are pharmacologically inactive, and the rapid dimerization reduces...

characterized human members consists of half-size ABC proteins which probably dimerize to form active membrane transporters. In our case, it is suggested that...

tyrosine kinase receptors (the VEGFRs) on the cell surface, causing them to dimerize and become activated through transphosphorylation. The VEGF receptors have...

tetrafluoroethylene. This conversion involves pyrolysis to give difluorocarbene, which dimerizes: 2 CHClF2 → C2F4 + 2 HCl The compound also yields difluorocarbene upon...

Interferon gamma (IFN-γ) is a family of dimerized soluble cytokine cytokines in the type II class of interferons. In humans, IFN-γ is the only type II...

cation [C6H4(CO2H)(N2)]+. This cation can be used to generate benzyne, dimerized to give diphenic acid, or undergo diazonium coupling reactions such as...

use of peroxydisulfuric acid gives rise to 1,4‑benzoxazine compounds. Dimerization of isatin with KBH4 in methanol yields Indirubin. This represents the...

of myosin or kinesin often adopt coiled-coil structures, as do several dimerizing proteins. A pair of coiled-coils – a four-helix bundle – is a very common...

activation itself or occurs after activation of individual dimers. EGFR dimerization stimulates its intrinsic intracellular protein-tyrosine kinase activity...

Takeda D, Robinson H, Kornbluth S, Swaminathan K, Dutta A (2004). "A dimerized coiled-coil domain and an adjoining part of geminin interact with two...

tendency to form dimers in solution, especially in the presence of oxygen. Dimerization greatly lowers the efficiency of subsequent coupling reactions such as...

remedy for hemorrhoids. On drying of these plants, the protoanemonin toxin dimerizes to non-toxic anemonin, which is further hydrolyzed to non-toxic dicarboxylic...

Georg G. Gross (2003). "Ellagitannin biosynthesis: laccase-catalyzed dimerization of tellimagrandin II to cornusiin E in Tellima grandiflora". Phytochemistry...

Cadiot–Chodkiewicz, Glaser, and Eglinton couplings all use air oxidation to dimerize a copper acetylide species: 2 R − ≡ − H → pyridine Cu ( OAc ) 2 R − ≡ −...

distance, although there is some debate as to its extent. BCl3 does not dimerize, although NMR studies of mixtures of boron trihalides shows the presence...

factor. This gene product only forms homodimers and, therefore, does not dimerize with the other three family members. It differs from alpha and beta members...

apocynin is not understood. In the experimental studies, apocynin is shown to dimerize and form diapocynin. Although, diapocynin seems to have beneficial effect...

variety of products. It is alkylated with butane to produce isooctane or dimerized to diisobutylene (DIB) and then hydrogenated to make isooctane, a fuel...

presence of catalysts, propylene will form various short oligomers. It can dimerizes to give 2,3-dimethyl-1-butene and/or 2,3-dimethyl-2-butene. or trimerise...

vinylidene ligands also affords carbyne complexes. Some metal carbynes dimerize to give dimetallacyclobutadienes. In these complexes, the carbyne ligand...

pyrolysis of polytetrafluoroethylene (PTFE). Tetrafluoroethylene thermally dimerizes to octafluorocyclobutane, which above 600 °C degrades to hexafluoropropylene...

and phenotype. There is some indication that mutations present in the dimerization domain of ADA2 predispose towards vasculitis-associated disease, whereas...

"One-Pot Synthesis Benzils from Aldehydes Via NHC-Catalyzed Benzoin Dimerization Under Metal-Free Conditions in Water". Journal of the Chilean Chemical...

dimerization interaction. Experimentally, it has been seen that, in vivo, mutating the Dimerization initiation site (DIS) obstructed the dimerization...

p-xylene or, more readily, the α-substituted derivatives. p-Xylylene dimerizes with moderate efficiency to give p-cyclophane: Further heating of the...

efficiently signal via endocannabinoid production to CB1 receptors, dimerization could be an effective way of forming signal complexes with optimal cannabinoid...

More reference expression data Gene ontology Molecular function protein dimerization activity protein homodimerization activity endopeptidase activity protease...

dimerize in the presence of FK1012, a derivative of the drug tacrolimus (FK506). This has made it a useful tool for chemically induced dimerization applications...

yeast ORC dimerizes in a cell cycle dependent manner to control licensing. [clarification needed] In turn, the process of ORC dimerization is mediated...

membrane bound segments, which indicates either gene duplication or dimerization. The silica deposition that takes place from the membrane bound vesicle...

explosives (4,4'-Dinitro-3,3'-diazenofuroxan). Furoxanes can be formed by dimerization of nitrile oxides. Clara Cena; Massimo Bertinaria; Donatella Boschi;...

block this dimerization mode. Due to decreasing dimerization energy down Group 14, while monohalogenated stannylenes and plumbylenes dimerize via the halogen-bridging...

oxidoreductase activity catalytic activity pyridoxal phosphate binding protein dimerization activity glycine binding glycine dehydrogenase (decarboxylating) activity...

molecules of the Meldrum's acid are believed to undergo a reductive dimerization to give an alkene linkage with one "Meldrum's acid" ring on each end...

Dimerization of a carboxylic acid....

vanadium(III) chloride. This results in a pinacol coupling reaction which dimerizes the material to provide an intermediate which is converted to its epoxide...

typically used as the cleavage domain in ZFNs. This cleavage domain must dimerize in order to cleave DNA and thus a pair of ZFNs are required to target non-palindromic...

specifically by the cyclic-GMP-AMP synthase (cGAS). Upon DNA recognition, cGAS dimerizes and stimulates the formation of cyclic-GMP-AMP (cGAMP). cGAMP then binds...

soluble in most organic solvents. It is prepared by the base-catalysed dimerization of diketene. Commonly used organic bases include imidazole, DABCO, and...

synthesis is in coupling reactions of alkanes. As an example tert-butanol is dimerized with Fenton's reagent and sulfuric acid to 2,5-dimethyl-2,5-hexanediol...

molecule (such as a rapamycin analog), the binding and signaling proteins dimerize together, allowing the CAR T cells to attack the tumor. Human EGFR truncated...

followed by an alpha-helical domain and a hydrophilic tail. Merlin can dimerize with itself and heterodimerize with other ERM family proteins. Merlin is...

membrane glycoprotein located in the endoplasmic reticulum that also dimerizes and comprises an N‑terminal β‑sandwich‑like domain, a central TIM barrel...

polypeptides contains a two domains: a DNA-binding domain and a dimerization domain. The dimerization domain binds to other LexA polypeptides to form dumbbell...

overturned by compensation mechanisms. In the case of HER2, which acts as a dimerization partner of other epidermal growth factor receptors (EGFR), constitutive...

3-Hydroxybutyraldehyde (acetaldol), an aldol, formally the product of the dimerization of acetaldehyde 4-Hydroxybutyraldehyde, a chemical intermediate Hydroxybutanal...

phosphaallenes quickly dimerize in a [2+2]- or [2+3]-cycloaddition to yield four- or five-membered rings. Thus, in order to prevent dimerization, a bulky moiety...

used as a compound of adhesives and oil-based varnishes. When TOFA is dimerized to dimer acid it is used for making polyamide and epoxy resin. DTO is...

sequences RNAcofold Calculate secondary structures of two RNAs with dimerization RNAdistance Calculate distances between RNA secondary structures RNAduplex...

with retinoid "X" receptors (RXRs; RXRα, RXRβ, RXRγ). RARs and RXRs must dimerize before they can bind to the DNA. Expression of more than 500 genes is responsive...

D-domain (Dimerization domain) is found in the upstream of the F-box domain, which is a conserved dimerization motif located in WD40 repeat F box proteins...

timescale due to migrations of the silyl substituents over the cage. The dimerization reaction observed for the carbon tetrahedrane compound is also attempted...

receptor (EGFR) on the cell surface. This stimulates ligand-induced dimerization, activating the intrinsic protein-tyrosine kinase activity of the receptor...

via binding of repressor molecules to two operators. These repressors dimerize, creating a loop in the DNA. The loop as well as hindrance from the external...

others. It belongs to the class of tetrahydroisoquinoline alkaloids. Dimerization of coclaurine leads to the biscoclaurine alkaloids such as cepharanthine...

CYCLE (CYC) (also known as dBMAL for the BMAL1 ortholog in mammals) dimerizes with CLK via their respective PAS domains. This dimer then recruits co-activator...

Dimanganese decacarbonyl, which has the chemical formula Mn2(CO)10, is a binary bimetallic carbonyl complex centered around the first row transition metal...

variable regions to fold together (about five amino acids), forcing scFvs to dimerize. This type is known as diabodies. Diabodies have been shown to have dissociation...

. {\displaystyle i=1-\left(1-{\frac {1}{n}}\right)\alpha .} For the dimerization of acetic acid in benzene: 2 CH3COOH ⇌ (CH3COOH)2 2 moles of acetic acid...

TLR5-flagellin complex: a new mode of pathogen detection, conserved receptor dimerization for signaling". Science Signaling. 5 (216): pe11. doi:10.1126/scisignal...

phenylpropanoid with a 9-carbon framework, recognized its substructure as being dimerized within the complex carpanone structure, and proposed a hypothesis of how...

directed to give either a quinone or a coupled product from oxidative dimerization. The latter process provides a high-yield route to 1,1-binaphthol: Such...

Rapamycin is used in biology research as an agent for chemically induced dimerization. In this application, rapamycin is added to cells expressing two fusion...

interaction with other transcription factors (e.g., homo- or hetero-dimerization) interacting with coregulatory proteins such as co-activators (e.g.,...

binding long-chain fatty acyl-CoA binding fatty-acyl-CoA binding protein dimerization activity Cellular component Golgi apparatus perinuclear endoplasmic reticulum...

differentiation. S100A8 and S100A9 (calgranulin A and B, respectively), dimerize to form calprotectin. Calprotectin, psoriasin (S100A7) and koebnerisin...

Although such compounds are not intrinsically unstable, they instead tend to dimerize or even polymerize. Moreover, the multiple bonds of the elements with n=2...

butadiene followed by oxidative dehydrogenation. The acid-catalyzed dimerization of styrene to give a 1,3-diphenylbutene, which then can be transformed...

organomanganese compounds, which then decompose to tert-butyl radicals, which dimerize. The full IUPAC name of the compound is 2,2,3,3-tetramethylbutane, but...

form appears to be important. Cyanamide dimerizes to give 2-cyanoguanidine (dicyandiamide). This dimerization is hindered or reversed by acids and is...

class is S-adenosyl-L-methionine:[3-phospho-D-glycerate-carboxy-lyase (dimerizing)]-lysine N6-methyltransferase. Other names in common use include rubisco...

bipartite singlets of many photons. Multiparticle singlets, as well as a dimerized phase of two-body singlets appear in antiferromagnatic models in optical...

expression data Gene ontology Molecular function DNA binding protein dimerization activity DNA-binding transcription factor activity DNA-binding transcription...

atoms. These approaches mainly involve reactions such as Diels-Alder dimerizations, photocycloadditions, cyclizations, oxidative and radical reactions...

less stable than MSP nanodiscs. Recent studies, however, showed that dimerization and polymerization of the peptides make them more stable. Another way...

alkenes are very reactive compared to ordinary alkenes. They are liable to dimerization creating cyclobutane rings, or react with oxygen to epoxides. The compound...

an N-terminal dimerization domain. Consisting of an intricate arrangement of α-helices, the rod domain, together with the dimerization-conducting N terminus...

oxide that was produced is oxidized to nitrogen dioxide, which is then dimerized into nitrogen tetroxide: 2 NO + O2 → 2 NO2 2 NO2 ⇌ N2O4, and the remainder...

in X-gal and form galactose and 5-bromo-4-chloro-3-hydroxyindole which dimerizes and oxidizes to 5,5'-dibromo-4,4'-dichloro-indigo, an intense blue product...

transcription activator activity, RNA polymerase II-specific protein dimerization activity RNA polymerase II cis-regulatory region sequence-specific DNA...

conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. That protein cleaves and activates caspases...

example of a distillable aldol (3-hydroxyaldehyde). Upon standing, it dimerizes reversibly to the dioxane derivative. Hydroxypivaldehyde is a precursor...

of D-BP deficiency. Other amino acid changes were seen to alter the dimerization of the protein, leading to improper folding. Many mutations have been...

activation of PKR. Binding to dsRNA is believed to activate PKR by inducing dimerization of the kinase domains and subsequent auto-phosphorylation reactions....

Vindoline is formed through biosynthesis from Tabersonine. Lochnericine Dimerization of catharanthine and vindoline Liu, J; Zhu, J; Tang, L; Wen, W; Lv, S;...

→ CH3(CH2=C−C=CH2)CH3 + 2 H2O The current industrial route involves dimerization of propene followed by dehydrogenation. In 1909, Fritz Hofmann and a...

It exists in dilute gases, but in a more concentrated form it readily dimerizes to ethane. It is routinely produced by various enzymes of the radical...

the lab in 2022 to test the proto-ribosome hypothesis. It was able to dimerize and to form peptide bonds. A much shorter RNA molecule has been synthesized...

(PA) domain, an M28 peptidase domain and a transferrin receptor-like dimerization domain. This protein mediates cellular uptake of transferrin-bound iron...

doi:10.1021/acs.joc.7b01225. PMID 28661157. Selective oxidative para C–C dimerization of 2,6-dimethylphenol Christophe Boldron, Guillem Aromí, Ger Challa,...

A variety of substituted 1,3-Cyclobutanediones form upon spontaneous dimerization of disubstituted ketenes. 2,2,4,4-Tetramethylcyclobutanedione is thus...

chaperones dissociate resulting in AhR translocating into the nucleus and dimerizing with ARNT (AhR nuclear translocator), leading to changes in gene transcription...

basic helix-loop-helix domain allows members of the protein family to dimerize with each other to affect gene transcription through binding to specific...

"Single-molecule analysis reveals human UV-damaged DNA-binding protein (UV-DDB) dimerizes on DNA via multiple kinetic intermediates". Proceedings of the National...

have several unique features, including chaperone-free folding and weak dimerization. Cryogenic electron microscopy showed that BtubA/B forms microtubules...

dehydrohalogenation of 1,3-dichloro-2-butene Cl−CH2−CH=CCl−CH3. It also arises via the dimerization of acetylene, which is catalyzed by copper(I) chloride. Dehydrogenation...

distinct mutations. Collagen VII is a very large molecule (300 kDa) that dimerizes to form a semicircular looping structure: the anchoring fibril. Anchoring...

fingers – with the catalytic domain of the FokI endonuclease which need to dimerize to cleave the double-strand DNA. The two proteins recognize two DNA sequences...

using a strong acid catalyst. In the NExOCTANE process, isobutylene is dimerized into isooctene and then hydrogenated to isooctane. In World War II, xylidine...

estrogenic. Anethole was demethylated to form anol and anol then spontaneously dimerized into dianol and hexestrol, with DES subsequently being synthesized via...

an alpha helix belonging to another similar polypeptide, facilitating dimerization and the formation of a complex resembling a zipper. ligand In biochemistry...

achieving a complete cure for genital herpes) The FokI catalytic domain must dimerize to cleave the DNA at the targeted site, and requires there to be two adjacent...

General scheme of dimerization of Grignard reagents and Schlenk equilibrium...

reacts with liquid ozone to form a hydrogen superoxide radical, which dimerizes: H + O3 → HO2 + O 2 HO2 → H2O4 Ozone is a toxic substance, commonly found...

Zhang KD, Dai JL, Zhu YY, Zhao X (June 2014). "Encapsulation enhanced dimerization of a series of 4-aryl-N-methylpyridinium derivatives in water: new building...

Urizar E, Lambert NA, et al. (March 2011). "Making Structural Sense of Dimerization Interfaces of Delta Opioid Receptor Homodimers". Biochemistry. 50 (10):...

produced by hydroboration. The lowest borane, BH3 exists only transiently, dimerizing instantly to form diborane, B2H6. Its adduct borane–tetrahydrofuran and...

PMID 25093327. Kronqvist, N.; et al. (2014). "Sequential pH-driven dimerization and stabilization of the N-terminal domain enables rapid spider silk...

describes a typical dimerization for Arduengo type carbenes (NHC's). Due to their apparent reluctance to participate in this dimerization pathway, carbenes...

the antiaromatic destabilization. Cyclobutadiene, for example, rapidly dimerizes with no potential energy barrier via a 2 + 2 cycloaddition reaction to...

reconfiguration. After progesterone binds to the receptor, restructuring with dimerization follows and the complex enters the nucleus and binds to DNA. There transcription...

inactive monomers within the cell, their activation relies on dimerization. This dimerization occurs when initiator caspases are recruited to large protein...

thermal displacement reactions that afford α-olefin chains. Above 150 °C, dimerization of the α-olefins occurs. Aluminum hydroxide, the byproduct of the synthesis...

1126/science.283.5404.987. PMID 9974392. Ebie AZ, Fleming KG (February 2007). "Dimerization of the erythropoietin receptor transmembrane domain in micelles". Journal...

quantitative yield by oxidation with lead(IV) acetate, which rapidly dimerizes to biphenylene in good yields. Electron deficient heterocycles, such as...

Bloch W (April 1992). "Prevention of pre-PCR mis-priming and primer dimerization improves low-copy-number amplifications". Nucleic Acids Research. 20...

N2/CO exchange at atmospheric pressure. Alkylidene ketenes can readily dimerize and participate in cycloaddition reactions. Often orange or red in color...

h-TRF1-AS. The protein structure contains a C-terminal Myb motif, a dimerization domain (TERF homology) near its N-terminus and an acidic N-terminus....

PDZ-ligand complex reveals a class I PDZ interaction and a novel PDZ-PDZ dimerization". J. Biol. Chem. 278 (48): 48099–104. doi:10.1074/jbc.M306919200. PMID 12954649...

David A.; Aggarwal, Aneel K.; Schildkraut, Ira (1 September 1998). "FokI dimerization is required for DNA cleavage". Proceedings of the National Academy of...

series of radical reactions, which is used in its dimerization to bipyridines. Radical dimerization of pyridine with elemental sodium or Raney nickel...

ground state. Unprotected carbene analogs, including germylenes, has a dimerization nature. Free germylenes can be isolated under the stabilization of steric...

diiodide (IH 2C)2C=CH 2 in the gas phase. However the product quickly dimerizes to yield 1,4-dimethylenecyclohexane, and also 2-methylpropene by abstracting...

only contains the extracellular domains D1 and D2. The FGFRs are known to dimerize as heterodimers and homodimers. So far, five distinct membrane FGFR have...

Oxidative Cleavage, Stereospecific Epoxidation, Transannulation, and Dimerization". pubs.acs.org. doi:10.1021/acs.jnatprod.5c01426. Retrieved 2026-05-17...

Eckert D, Bass B (2006). "RDE-4 preferentially binds long dsRNA and its dimerization is necessary for cleavage of dsRNA to siRNA". RNA. 12 (5): 807–18. doi:10...

interactions. Procaspase-8 activation is thought to occur through a dimerization process with other procaspase-8 molecules, known as an induced proximity...

allows rapid and tight regulation of the enzyme. Activation involves dimerization and often oligomerisation of pro-caspases, followed by cleavage into...

conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein cleaves and activates caspases...

running about half the length of the molecule. Also, MOG was shown to dimerize in solution, and the shape complementarity index is high at the dimer interface...

protein forms a 'super-sandwich' (⍺-β-β-⍺-⍺-β-β-⍺) structure. In order to dimerize, the C-terminals of each subunit extend out from the core and interact...

H-NS is characterized by an N-terminal domain (NTD) consisting of two dimerization sites, a linker region that is unstructured and a C-terminal domain (CTD)...

(k at 298 K = 8×106 M s): 2 HNO → N2O + H2O The reaction proceeds via dimerization to hyponitrous acid, H2N2O2, which subsequently undergoes dehydration...

are replaced with C–F bonds. Octafluorocyclobutane is produced by the dimerization of tetrafluoroethylene and the reductive coupling of 1,2-dichloro-1,1...

able to form activin heterodimers with βA or βB subunits but is unable to dimerize with inhibin α. Activin is produced in the gonads, pituitary gland, placenta...

contains a zinc domain and a FokI endonuclease domain. The FokI domains must dimerize for activities, thus narrowing target area by ensuring that two close DNA-binding...

of LiAlH4 to 94. The hypotensive95 pseudo-benzylic alcohol 95 and its dimerization product 96, whose biological profile is completely unknown, are the most...

elemental sulfur. The main route to cyclooctane derivatives involves the dimerization of butadiene, catalysed by nickel(0) complexes such as nickel bis(cyclooctadiene)...

to interact with a specific PAMP. TLRs tend to dimerize, TLR4 forms homodimers, and TLR6 can dimerize with either TLR1 or TLR2. Interaction of TLRs with...

Is Associated with Aberrant Intermolecular Disulfide Bond Formation (Dimerization) in the Endoplasmic Reticulum". Journal of Biological Chemistry. 277...

octameric quaternary structure, two dimerization types can be seen that in turn, form the octamer structure. Dimerization is an important aspect of protein...

(2017-01-18). "Mechanism of Single-Site Molecule-Like Catalytic Ethylene Dimerization in Ni-MFU-4l". Journal of the American Chemical Society. 139 (2): 757–762...

receptor dissociates from accessory proteins, translocates into the nucleus, dimerizes, and then stimulates transcription of androgen-responsive genes. The binding...

acidic workup. The Kolbe electrolysis is an electrolytic, decarboxylative dimerization reaction. It gets rid of the carboxyl groups of two acid molecules, and...

stable RNA and increase the rate of synthesis. This is done by binding (dimerization) with the AP-1 transcription factor to give a primary transcript that...

interferons and interleukins, to cell-surface receptors, causes the receptors to dimerize, which brings the receptor-associated JAKs into close proximity. The JAKs...

properties and stability of condensates: for example, UV‑induced thymine dimerization within DNA‑based condensates alters their mechanochemistry and fusion...

Jeffrey D. (April 1970). "Kinetics of aqueous indium(III) perchlorate dimerization". The Journal of Physical Chemistry. 74 (9): 1825–1828. doi:10.1021/j100704a001...

3-Triphenyl-2-propyn-1-ol with thionyl chloride. The resulting chloroallene undergoes dimerization and dehydrochlorination to give rubrene. Rubrene, like other polycyclic...

ErbB3 that causes the protrusion of the dimerization loop in subdomain II, activating the protein for dimerization. ErbB3 has been shown to bind the ligands...

Milatovich A, Mendel DB, Crabtree GR, Francke U (April 1993). "Genes for the dimerization cofactor of hepatocyte nuclear factor-1 alpha (DCOH) are on human and...

monolignols. Thus, most lignans feature a C18 cores, resulting from the dimerization of C9 precursors. The coupling of the lignols occurs at C8. Eight classes...

electron oxidation generates the triphenylphosphonium radical cation, which dimerizes to the hexaphenyl-1,2-diphosphonium dication [Ph3P–PPh3]2+. Irradiation...

which was developed by René Bohn in 1901: Synthesis of indanthrone By dimerization of 2-aminoanthraquinone (1) under strongly alkaline conditions at 220-235...

Johannes; Radacki, Krzysztof; Kupfer, Thomas (2010). "Chemical Reduction and Dimerization of 1-Chloro-2,3,4,5-tetraphenylborole". Chemistry – A European Journal...

unconventional myosin with the longest tail (1360 aa). The tail is expected to dimerize, resulting in a two-headed molecule. Unconventional myosins have diverse...

reaction, is an organic reaction describing (in its original scope) the dimerization or isomerization of electron-deficient alkenes such as enones by action...

of these two angiogenic growth factors. Though sFlt-1 can effectively dimerize, its lack of a kinase domain means that no tyrosine phosphorylation occurs...

chain. This protein contains an I domain, is expressed in muscle tissue, dimerizes with beta 1 integrin in vitro, and appears to bind collagen in this form...

forms a salt bridge with arginine and a hydrogen bond with glutamine. Dimerization is essential to maintaining function as the active site is found at this...

upon by StaD to form an uncharacterized intermediate proposed to be the dimerization product between 2 imine molecules. Chromopyrrolic acid is the molecule...

Pleiadene generation and dimerization...

Bromotyrosine Alkaloids from the Bahamian Marine Sponge Aiolochroia crassa. Dimerization and Oxidative Motifs". The Journal of Organic Chemistry. 87 (19): 12831–12843...

monomeric nucleases often involve high levels of off-target effects, dimerization is an attractive strategy. In a dimer system, both nucleases must bind...

nervous system. When prolactin binds to the receptor, it causes it to dimerize with another prolactin receptor. This results in the activation of Janus...

oligomerization and dimerization of conjugated dienes. For example, 1,5-cyclooctadiene and 4-vinylcyclohexene are produced by dimerization of 1,3-butadiene...

Chen H, Yang S, He F (August 2002). "Identification of hepatopoietin dimerization, its interacting regions and alternative splicing of its transcription"...

reaction, an aldehyde, formed in situ from an alcohol, self-condenses to the dimerized alcohol. Auwers synthesis Aldol addition Klein, David R. (December 22...

impact a protein's localization, stability, and whether or not it can dimerize or form stable bonds with other substances. It is vital to pinpoint which...

flavanones, anthocyanidins, and isoflavonoids. The phenolic unit can be found dimerized or further polymerized, creating a new class of polyphenol. For example...

or CK5, is a protein that is encoded in humans by the KRT5 gene. It dimerizes with keratin 14 and forms the intermediate filaments (IF) that make up...

to viral infection. Aggregated MAVS have been found to activate IRF3 dimerization. A 2015 study shows phosphorylation of innate immune adaptor proteins...

due to their enhanced sequence specificity. ZFN work in pairs, their dimerization being mediated in-situ through the FokI domain. Each zinc finger array...

their high degree of toxicity to proliferating cells.[citation needed] Dimerization consists of the bonding of two monomers to form an oligomer, such as...

substrate CN+1 carboxylic acids are observed due to fragmentation and dimerization of carbon monoxide-derived carbenium ions, especially since each step...

dimerization interface) and the virus-type replication-repair nuclease module (VRR_NUC, catalytic site) (Figure 1). DNA binding promotes dimerization...

(2026). "A Novel Small-Molecule TLR7 Agonist AXC-715 Stabilizes TLR7 Dimerization and Exhibits Broad-Spectrum Antiviral Activity". Microorganisms. 14 (4):...

to regenerate active catalyst is needed in this reaction. Reductive dimerization of electrophiles has long been known (Wurtz reaction, Ullman reaction...

Dimerization in Ferrimagnetic Chains and Square Lattices", J. Phys. Condensed Matter 12, 9949 (2000). Aiman Al-Omari and A.H. Nayyar, "Dimerization of...

PMC 10318606. PMID 37348461. "Contextual computation by competitive protein dimerization networks". Cell. 188 (7). Bintu, Lacramioara; Yong, John; Antebi, Yaron...

thumbnail). Depending on conditions, such as pH, these dimers can themselves dimerize to form tetramers. Each monomer in the complex has a substrate binding...

domain (aa593-685): mediates receptor-specific recruitment and STAT dimerization via phosphorylated tyrosine residue Transcriptional activation domain...

bromine than predicted by the equation above. For example, some alkenes dimerize in the presence of bromine. Allylic bromination is another problem. The...

is fundamental for both dimerization of the heavy chains and formation of NM IIA functional filaments. Two heavy chains dimerize through the tail domain...

PMEL. UV radiation causes damage to the DNA of cells, typically thymine dimerization, which, when unrepaired, can create mutations in the cell's genes. This...

commercially) focused on fatty alcohols, it has been investigated for the dimerization of ethanol to butanol. Organometallic catalysts have been investigated...

domain upon binding to its recognition site. Cleavage only occurs upon dimerization, when the recognition domain is bound to its cognate site and in the...

promote cross-coupling a diene to an olefin. Fe(acac)3 catalyzes the dimerization of isoprene to a mixture of 1,5-dimethyl-1,5-cyclooctadiene and 2,5-dimethyl-1...

double bond rearrangement (8,9) is then postulated to directly precede dimerization to Absinthin [E] via a naturally occurring Diels-Alder reaction [10]...

TK, Sondek J (2002). "A unique fold of phospholipase C-beta mediates dimerization and interaction with G alpha q". Nat. Struct. Biol. 9 (1): 32–6. doi:10...

induces a conformational change in the receptor that causes receptor dimerization and activation.[citation needed] The binding of ANP to its receptor causes...

contains three functional domains, the ATP-binding, protein-binding, and dimerizing domain, each of which playing a crucial role in the function of the protein...

(December 1991). "A mutation in a mild form of galactosialidosis impairs dimerization of the protective protein and renders it unstable". The EMBO Journal...

"Effect of carbonyl cyanide m-chlorophenylhydrazone (CCmCP) on the dimerization of lipoprotein lipase". Biochimica et Biophysica Acta (BBA) - Lipids...

the product of this reaction was the expected anol, a highly reactive dimerization product in the mother liquors called dianol was also discovered by Charles...

high disorder. Some proteins in this class function as monomers, but dimerization or higher-order oligomerization is common. The number of single-pass...

cells, having unique palindromic sequences and encoding a leucine zipper dimerization motif". Biochemical and Biophysical Research Communications. 243 (2):...

center of cyclopentanone. Hydrolysis liberates the alkynyl alcohol. The dimerization of acetylene to vinylacetylene proceeds by insertion of acetylene into...

1074/jbc.M103674200. PMID 11555640. Ma K, Vattem KM, Wek RC (May 2002). "Dimerization and release of molecular chaperone inhibition facilitate activation of...

vesicle, forming a helical polymer arranged such that the GTPase domains dimerize in an asymmetric manner across helical rungs. The polymer constricts the...

silicon bonded to a divalent silylene. The mixed-valent dimer then itself dimerizes, forming a four-silicon silene with 229 pm Si=Si double bond. Though exceptionally...

adiponitrile. Adiponitrile is obtained by hydrocyanation of butadiene or by dimerization of acrylonitrile and is converted by catalytic hydrogenation into hexamethylenediamine...

cofactor and point mutations in the enzyme. A G473D mutation impairs dimerization and catalysis in human sulfite oxidase. Sulfur metabolism Bioinorganic...

enol silanes through treatment with ceric ammonium nitrate. Oxidative dimerization of aldehydes in the presence of amines proceeds through the formation...

protein from Forsythia intermedia, production of (+)-pinoresinol is greatly enriched while production of other products of dimerization is inhibited....

of the resultant β-ketoacid yields a tricyclic ketone. Oxidation and dimerization yields the completed natural product. Three scytonemin biosynthetic enzymes...

accessible by weakly basic hydrolysis of chlorotrimethylsilane, since the dimerization can thus be avoided. Trimethylsilanol can also be obtained by the basic...

from the pro-region by proteolytic cleavage. The mature TGF-β protein dimerizes to produce a 25 KDa active protein with many conserved structural motifs...

Fleming KG, Hill RB (Oct 2012). "A designed point mutant in Fis1 disrupts dimerization and mitochondrial fission". Journal of Molecular Biology. 423 (2): 143–58...

1038/s41560-018-0134-z. ISSN 2058-7546. A. Distler (2014). "The effect of PCBM dimerization on the performance of bulk heterojunction solar cells". Advanced Energy...

Bloch W (April 1992). "Prevention of pre-PCR mis-priming and primer dimerization improves low-copy-number amplifications". Nucleic Acids Research. 20...

However exposure to the thrombospondin ligand causes CD36 to dimerize. This dimerization has been proposed to play an important role in CD36 signal transduction...

phosphorylation recruits STAT transcription factors, predominantly STAT5, which dimerize and migrate to the cell nucleus where they bind to DNA. with an "express...

is the beta sheet, leading researchers to hypothesize the presence of dimerization domains within ICAM-1. The protein encoded by this gene is a type of...

pelargonic acid can be produced in a two-step process beginning with coupled dimerization and hydroesterification of 1,3-butadiene. This step produces a doubly...

mechanistic behavior. For example, it has been used to study the rate of dimerization of substrates upon electrochemical reduction. In 2013–2014 Atangana et...

McDonald, Kevin P.; Tait, Steven L.; Flood, Amar H. (2014). "Anion-induced dimerization of 5-fold symmetric cyanostars in 3D crystalline solids and 2D self-assembled...

produced by hydroformylation of octenes. Isomeric octenes are produced by dimerization of butenes. These alcohol mixtures are used as solvents in paints and...

trimethylaluminium (Al2Me6), usually feature tetrahedral Al centers formed by dimerization with some alkyl group bridging between both aluminium atoms. They are...

carbon-halogen bond of the α-haloester by oxidative addition 1. This compound dimerizes and rearranges to form two zinc enolates 2. Unlike lithium enolates and...

ion pair (CIP). Due to the high steric demand of the TMP ligand the dimerization process is sterically hindered. This is why the TMP-Turbo-Hauser base...

helix-loop-helix (bHLH) domain. This protein is located in the cell nucleus and must dimerize with another bHLH protein in order to bind DNA. N-Myc is highly expressed...

The stalks of two KHCs intertwine to form a coiled coil that directs dimerization of the two KHCs. In most cases transported cargo binds to the kinesin...

and H. NKG2D is an activating receptor on the NK cell surface. NKG2A dimerizes with CD94 to make an inhibitory receptor (CD94/NKG2A). IPH2201 is a monoclonal...

Swaminathan, V. N.; Carell, T; Zinth, W; Kohler, B; et al. (2007). "Thymine dimerization in DNA is an ultrafast photoreaction". Science. 315 (5812): 625–629....

cobaltocene, rhodocene does not exist as a monomer, but spontaneously dimerizes by formation of a C–C bond between Cp rings. Co(C5H5)2 is a common one-electron...

data BioGPS n/a Gene ontology Molecular function DNA binding protein dimerization activity DNA-binding transcription factor activity transcription factor...

being investigated. AP-1 transcription factor is assembled through the dimerization of a characteristic bZIP domain (basic region leucine zipper) in the...

allows BB binding while inhibiting proliferation by impairing receptor dimerization". J. Biol. Chem. 272 (28): 17400–17404. doi:10.1074/jbc.272.28.17400...

thought to be synthesized by the PR-10 protein Hyp-1 through emodin dimerization, but despite confirming Hyp-1’s structure and ligand-binding capability...

reaction with sodium hydroxide (NaOH). Unfortunately, instantaneous dimerization of the resulting phenol produces trace amounts of 2,3,7,8-tetrachlorodibenzo-p-dioxin...

inducing mutations along length of DUE-B sequence, but in all cases dimerization abilities remaining intact. Upon binding DNA, C-terminus becomes ordered...

(2006). "Metallocene and Related Catalysts for Olefin, Alkyne and Silane Dimerization and Oligomerization". Coordination Chemistry Reviews. 250 (1–2): 66–94...

synthesis of the compound triquinacene which was thought to be able to simply dimerize to dodecahedrane. Other groups were also in the race, for example that...

receptor heterodimers form in the cytoplasm through alternative dimerization interfaces". Molecular and Cellular Biology. 21 (3): 781–93. doi:10.1128/MCB...

mutation on the surface of Staphylococcus aureus Sortase A can disrupt its dimerization". Biochemistry. 47 (6): 1667–74. doi:10.1021/bi7014597. PMID 18193895...

Horejsi V, Strominger JL (December 2002). "Disulfide bond-mediated dimerization of HLA-G on the cell surface". Proc. Natl. Acad. Sci. U.S.A. 99 (25):...

Banham, AH.; Asanteowusu, RN.; Casselton, LA. (1995). "An N-terminal dimerization domain permits homeodomain proteins to choose compatible partners and...

as monomers, heterodimers with other nuclear receptors, or homodimers. Dimerizing with different nuclear receptors leads to the regulation of different...

(S99T/F113A) cyclophilin mutant. Cyclosporin A is a chemical inducer of dimerization (CID) of cyclophilin. This first bump-and-hole pair was engineered to...

donating aldehyde with a proton accepting aldehyde to avoid undesired homo-dimerization. The reaction can be extended to aliphatic aldehydes with base catalysis...

receptor heterodimers form in the cytoplasm through alternative dimerization interfaces". Molecular and Cellular Biology. 21 (3): 781–793. doi:10...

or even towards themselves: their molecules will often spontaneously dimerize or polymerize if they come in contact with each other. They are countered...

necessary to run the reaction in an inert atmosphere to avoid the unwanted dimerization. Copper-free variations to the Sonogashira reaction have been developed...

Mengke; Qing, Rui; Tao, Fei; Xu, Ping; Zhang, Shuguang (2023). "Dynamic Dimerization of Chemokine Receptors and Potential Inhibitory Role of Their Truncated...

to (+)-pinoresinol in the presence of a one-electron oxidant through dimerization of stereospecific radical intermediate. Pinoresinol is subsequently reduced...

unstable as the molecules easily react with the other photolysis products, or dimerize, eliminating argon. The argon coinage metal monohalides were the first...

This ring is a trimer of dimers: Rpt1/Rpt2, Rpt6/Rpt3, and Rpt4/Rpt5 dimerize via their N-terminal coiled-coils. These coiled-coils protrude from the...

to the meta positions on the phenyl rings causes the radical to readily dimerize to (3,5-tBu2H3C6)3C–C(C6H3-3,5-tBu2)3. Initially this discovery puzzled...

"The two GAF domains in phosphodiesterase 2A have distinct roles in dimerization and in cGMP binding". Proceedings of the National Academy of Sciences...

nonplanar and can be oxidized to their radical cations. Photolysis leads to dimerization via a [2+2] cycloaddition. Thianthrene is dibenzo-1,4-dithiin. 1,2-Dithiins...

PMC 362236. PMID 2320002. Hai T, Curran T (May 1991). "Cross-family dimerization of transcription factors Fos/Jun and ATF/CREB alters DNA binding specificity"...

Binding interaction between NGF and the TrkA receptor facilitates receptor dimerization and tyrosine residue phosphorylation of the cytoplasmic tail by adjacent...

colorless liquid with a strong odor. 1,5-Cyclooctadiene can be prepared by dimerization of butadiene in the presence of a nickel or iron catalyst, a coproduct...

(CBS) Dicyclohexyl-2-benzothiazolesulfenamide (DCBS) Oxidative dimerization of MBT gives mercaptobenzothiazole disulfide (MBTS), and sulfenamide...

can be produced conveniently and nearly all are unstable (see: carbene dimerization). An exception are dihalocarbenes such as dichlorocarbene or difluorocarbene...

David A.; Aggarwal, Aneel K.; Schildkraut, Ira (September 1998). "Fok I dimerization is required for DNA cleavage". Proceedings of the National Academy of...

tetratricopeptide repeats (TPRs); the 13th repeat is truncated. These subunits are dimerized by TPR repeats 6 and 7. OGT is highly expressed in the pancreas and also...

The systematic name of this enzyme class is glyoxylate carboxy-lyase (dimerizing tartronate-semialdehyde-forming). Other names in common use include tartronate...

expression data Gene ontology Molecular function DNA binding protein dimerization activity RNA polymerase II activity DNA-directed 5'-3' RNA polymerase...

when fused to four ERT2 domains. Intein-inducible split-Cas9 allows dimerization of Cas9 fragments and rapamycin-inducible split-Cas9 system developed...

−196 °C (77 K) from photolysis of diazocyclopentadiene, which induces dimerization of cyclopentadiene-derived carbenes. The compound was isolated in 1986...

John C. Stowell (1971). "tert-Alkylnitroso compounds. Synthesis and dimerization equilibriums". J. Org. Chem. 36 (20): 3055–3056. doi:10.1021/jo00819a038...

used in pesticide formulations until 1955. Mirex was produced by the dimerization of hexachlorocyclopentadiene in the presence of aluminium chloride. Mirex...

beta-sandwich structure where the fold is then shared by all galectins. The dimerization, the non-covalent association of two identical monomers, is useful for...

M011311200. PMID 11278883. Zhu CC, Cook LB, Hinkle PM (August 2002). "Dimerization and phosphorylation of thyrotropin-releasing hormone receptors are modulated...

give the strong Lewis acid, AlBr3. Regarding the tendency of Al2Br6 to dimerize, it is common for heavier main group halides to exist as aggregates larger...

DNA is that derived from the heterodimer: AP3 and PI, or DEF and GLO, dimerize. This is the form in which they are able to function. The GLO/PI lines...

precursor to vinylcyclohexene dioxide. It is produced by buta-1,3-diene dimerization in a Diels-Alder reaction. The reaction is conducted at 110 - 425 °C...

(August 1995). "Multiple Bcl-2 family members demonstrate selective dimerizations with Bax". Proceedings of the National Academy of Sciences of the United...

"Activation of MTK1/MEKK4 by GADD45 through induced N-C dissociation and dimerization-mediated trans autophosphorylation of the MTK1 kinase domain". Molecular...

Ciulli, Alessio (10 October 2017). "Homo-PROTACs: bivalent small-molecule dimerizers of the VHL E3 ubiquitin ligase to induce self-degradation". Nature Communications...

ions [Cp2Rh]+ are very stable, unlike the neutral monomers Cp2Rh which dimerize immediately at room temperature and they have been observed in matrix isolation...

become degraded and therefore coalesce and precipitate. However, upon dimerization of alkaline phosphatase, the bonds maintaining its secondary and tertiary...

It is an unusual "example of an odd-electron molecule stable toward dimerization" (nitric oxide being another example). ClO2 crystallizes in the orthorhombic...

Jankowska E, et al. (2001). "Human cystatin C, an amyloidogenic protein, dimerizes through three-dimensional domain swapping" (PDF). Nat. Struct. Biol. 8...

generation and maintenance of the ER sheets This is thought to occur after dimerization of CLIMP-63's luminal COILED-COIL domains in cis (two CLIMP-63 proteins...

of two p53 monomers joined through their oligomerization domains. The dimerization interface spans residues 325–356 and includes a beta-strand (residues...

extremely basic, the salt slowly reacts with acetonitrile, inducing dimerization to CH3C(NH2)=CHCN, which co-crystallizes. Tetramethyl­phosphonium fluoride...

ortho quinones upon oxidation. These products are unstable and undergo dimerization. (5) When external nucleophiles are added to phenolic oxidations, further...

tris(silox)tantalum to form an unstable tetrahedral intermediate, which quickly dimerizes. Then, the cleavage of the four-membered ring as shown in the diagram...

is driven by palmitoylation and dimerization, a process facilitated by cholesterol within lipid rafts. Once dimerized, the receptor undergoes autophosphorylation...

have different isoforms, and some combination of isoforms result in dimerization while other combinations do not. For example, beta1 binds both gamma...

It has been reported that naloxazone is unstable in acidic solution, dimerizing into the more stable and much more potent antagonist naloxonazine via...

translation dynamics, post-translational protein modification, protein dimerization, and intracellular travel to the nucleus. Across species, proteins involved...

synthesized and tested a few "half-PTC" two-helix sequences. Some of them dimerize and form peptide bonds when tRNA is given. A designed minimized version...

hydrolyzes the indican, releasing β-D-glucose and indoxyl. The indoxyl dimerizes in the mixture, and after 12–15 hours of fermentation yields the yellow...

Convention on Persistent Organic Pollutants in 2009. Chlordecone is made by dimerizing hexachlorocyclopentadiene and hydrolyzing to a ketone. It is also the...

much vitamin A in retinoid form can be harmful. The body converts the dimerized form, carotene, into vitamin A as it is needed, so high levels of carotene...

PMID 19341785. Witt SH, Labeit D, Granzier H, Labeit S, Witt CC (2005). "Dimerization of the cardiac ankyrin protein CARP: implications for MARP titin-based...

expression data Gene ontology Molecular function nucleotide binding protein dimerization activity protein homodimerization activity ADP binding phospholipid transporter...

from partial oxidation of a thiocarbonyl to the thiosulfine, and then dimerization. In such cases the ring adduct is in quilibrium with the reagents, and...

FGF-FGFR-heparin complex reveals a dual role for heparin in FGFR binding and dimerization". Molecular Cell. 6 (3): 743–750. doi:10.1016/s1097-2765(00)00073-3....

intermediates in relative isolation, particularly compounds prone to dimerization like cyclobutadiene. Cram, Donald; et al. (1997). Container molecules...

expression data BioGPS n/a Gene ontology Molecular function protein dimerization activity Cellular component nuclear membrane integral component of membrane...

programmed cell death. The binding of NGF to TrkA leads to a ligand-induced dimerization, and a proposed mechanism by which this receptor and ligand interact...

FOSL1, and FOSL2. These genes encode leucine zipper proteins that can dimerize with proteins of the JUN family, thereby forming the transcription factor...

normally encode for proteins that form dimers to function: MLH1 protein dimerizes with PMS2 protein to form MutLα, which coordinates the binding of other...

Jin-Hu; Zhu, Rong (2022). "Synthesis of Polydiynes via an Unexpected Dimerization/Polymerization Sequence of C3 Propargylic Electrophiles". Journal of...

similar reaction with phenylazotriphenylmethane in benzene. Again, the dimerization product of the persistent radical (phenylcyclohexydienyl) was absent...

PMID 16659039. Stafford, Helen A.; Brown, Mark A. (1977). "Photochemical Dimerization of Ferulic Acid by Chloroplasts from Sorghum". Plant Physiology. 59 (1):...

hand, all pro-apoptotic proteins contain a BH3 domain necessary for dimerization with other proteins of Bcl-2 family and crucial for their killing activity...

DesK-P will transfer its phosphoryl group to DesR. Two DesR-P proteins will dimerize and bind to the DNA promoters of the des gene and recruit RNA polymerase...

from top): Beta scission to give either an acid chloride or ketone. Dimerization to give a peroxide cross-link. Hydrogen abstraction followed by loss...

Halazonetis TD, Georgopoulos K, Greenberg ME, Leder P (December 1988). "c-Jun dimerizes with itself and with c-Fos, forming complexes of different DNA binding...

factors, platelet-derived growth factors, and stem cell factor. This dimerizes the transmembrane receptor to another RTK receptor, which causes the autophosphorylation...

including labile but complexes with some noble gases. Norbornadiene was dimerized photochemically in the presence of Cr(CO)6, similarly to other metal complexes...

ectodomains, ED1 to ED3, and a transmembrane segment. ED2 includes the dimerization interface, two glycosylation sites, and the peptide of fusion with the...

of Vps27 (vacuolar protein sorting protein 27) and Hse1. Vps27 and Hse1 dimerize through antiparallel coiled-coil GAT (so named after proteins GGA and Tom1)...

ovarian BH3 domain-containing proapoptotic Bcl-2 protein capable of dimerization with diverse antiapoptotic Bcl-2 members". Molecular Endocrinology. 12...

{\displaystyle r_{zj}=2} for a single z {\displaystyle z} ; that is, a dimerization reaction. Each of these is discussed in detail below. One can define...

57. doi:10.3389/fnins.2014.00057. PMC 4018553. PMID 24834023. OX1–CB1 dimerization was suggested to strongly potentiate orexin receptor signaling, but a...

action of clozapine in the context of dopamine D1-D2 receptor hetero-dimerization--a working hypothesis". Pharmacological Reports. 60 (5): 581–7. PMID 19066405...

proteins, such as BiP, in order to fold correctly. VSG efficiently folds and dimerizes (suggesting intrinsically favorable folding) and is transported through...

"Synthesis of a Covalent Monolayer Sheet by Photochemical Anthracene Dimerization at the Air/Water Interface and its Mechanical Characterization by AFM...

Cierpicki T, Paduch M, Derewenda ZS, Otlewski J (March 2006). "The dimerization mechanism of LIS1 and its implication for proteins containing the LisH...

(December 1991). "Activation of the human c-kit product by ligand-induced dimerization mediates circular actin reorganization and chemotaxis". The EMBO Journal...

(August 2001). "SATB1 cleavage by caspase 6 disrupts PDZ domain-mediated dimerization, causing detachment from chromatin early in T-cell apoptosis". Molecular...

for recognition and localization to Ku70/80 (5). The two XRCC4 proteins dimerize together and bind to Ku70/80 at the ends of the DNA strands to promote...

and cryptochrome (Cry) genes cannot proceed until CLOCK and BMAL1 have dimerized and bound to the E-box element, a process initiated by CREB-binding protein...

chemotherapeutic agents. c-Myc, a transcription factor, can be inhibited during its dimerization with Max protein by molecules such as IIA6B17 and omomyc. Inhibition...

preparations of anol failed to confirm these findings, and it was found that dimerization of anol into dianol and hexestrol can rapidly occur and that the latter...

proteins simultaneously, as in the case of ligand-dependent receptor dimerization. For a protein with an interacting partner, its functional homology to...

Each subunit consists six β-strands, β A-F, and ten α-helices, α 1–10. Dimerization occurs along the faces of β C and α 3 of both monomers. BPGM is roughly...

the first to isolate cyclopropenylidenes, mesoionic carbenes that cannot dimerize, resulting in a relaxation of steric requirements for their isolation More...

tyrosine kinase receptors PDGF receptor-α and -β. These two receptor isoforms dimerize upon binding the PDGF dimer, leading to three possible receptor combinations...

STRUCTURAL BASIS FOR THE MONOMERIZATION OF THE DES-[PHE(B25)] INSULIN AND THE DIMERIZATION OF NATIVE INSULIN 1mpj: X-RAY CRYSTALLOGRAPHIC STUDIES ON HEXAMERIC INSULINS...

Toro-Roman, Alejandro; Wu, Ti; Stock, Ann M. (December 2005). "A common dimerization interface in bacterial response regulators KdpE and TorR". Protein Science...

determination of dimerization of SorCS2 and the other two SorCS proteins with only few monomeric structures found. This dimerization is promoted by deglycosylation...

as a Diels-Alder self-reaction, providing a detailed analysis of the dimerization products and recognizing the importance of the conjugated system in the...

sensitivity by synthesizing cGMP. Low concentrations of calcium cause the dimerization of RETGC-1 proteins through stimulation from guanylate cyclase-activating...

ketones, derivatives functionalized with electrophiles, or products of dimerization. The mechanism of reduction itself depends on the nature of the reducing...

(residues 33–97) which connects the dimerization and DNA binding domains. Crystal structures have been solved for the dimerization domain, which forms a four-helix...

charge from oxygen to nitrogen. Upon condensing to a liquid, nitric oxide dimerizes to colorless dinitrogen dioxide (O=N–N=O), but the association is weak...

route to 1-octanol, but using C4 + C4 building strategy. 1,3-Butadiene is dimerized concomitant with the addition of one molecule of water. This conversion...

changes following selective phosphorylation, and its redox-sensitive dimerization. However, mounting evidence demonstrated that occludin is not only present...

expression data BioGPS n/a Gene ontology Molecular function protein dimerization activity intracellular calcium activated chloride channel activity Cellular...

factor (NGF) After NGF is bound to TrkA this leads to a ligand-induced dimerization causing the autophosphorylation of the tyrosine kinase segment, which...

(June 2008). "Structural properties of AMP-activated protein kinase: dimerization, molecular shape, and changes upon ligand binding". The Journal of Biological...

ActA, a natively unfolded protein, enhances F-actin assembly without dimerization". The Journal of Biological Chemistry. 283 (35): 23852–23862. doi:10...

that TIM directly binds with PER. During the early evening, PER and TIM dimerize and accumulate. Late at night, the dimer travels into the nucleus to inhibit...

determine because the chemical can disproportionate to form [YbCl6]−3 or dimerize. The Yb2Cl6 species was detected by electron impact (EI) mass spectrometry...

argument for the occurrence of the Peierls transition, sometimes called dimerization. The earliest written record of the Peierls transition was presented...

Yutaka; Ikawa, Tsuneo (October 1991). "A Novel Hydrodechlorinative Dimerization of Chlorofluorocarbons over Supported Ni Catalysts". Chemistry Letters...

domains) or cell-permeable small molecules by chemically induced dimerization. In a living cell, molecular motifs are embedded in a bigger network...

cysteine is involved in the formation of a covalent bond, leading the dimerization. However, in the BMP-15 the homodimers form as a non-covalent bond is...

proximity this cyclophane type also serves as guinea pig for photochemical dimerization reactions as illustrated by this example: The product formed has an octahedrane...

(1979). "Electrochemical Reduction Pathways of the Rhodocenium Ion. Dimerization and Reduction of Rhodocene". Inorganic Chemistry. 18 (6): 1443–1446....

This stabilization allows HIF-1α entering into the cell nucleus and to dimerize with HIF-1β, forming the active HIF-1 transcription complex, which then...

(May 2008). "Structure of the MDM2/MDMX RING domain heterodimer reveals dimerization is required for their ubiquitylation in trans". Cell Death Differ. 15...

PJ, Fourrier C, Chopin P, Valentin JP, John GW, et al. (March 1998). "Dimerization of sumatriptan as an efficient way to design a potent, centrally and...

oxidants abstract α hydrogens in a free-radical process, leading to dimerization. Azoxyarenes ortho to a benzylic carbon with good leaving group eliminate...

conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme in the form of a heterotetramer. The precursor...

Comer JD, Vitalis EA, Mangili JA (Dec 1990). "Type II regulatory subunit dimerization determines the subcellular localization of the cAMP-dependent protein...

genes (STING) protein. There are 3 disease causing mutations in the dimerization domain of STING that cause SAVI; V155M, N154S, and V147L.[citation needed]...

PMID 16946301. Lagane B, Chow KY, Balabanian K, et al. (July 2008). "CXCR4 dimerization and beta-arrestin-mediated signaling account for the enhanced chemotaxis...

all other type II restriction endonucleases. It also has an N-terminal dimerization subdomain formed by a short α-helix, a two-stranded antiparallel -sheet...

develop through the in vitro oxidation of 1,2,3,4,6-pentagalloylglucose or dimerization processes resulting in hydrolyzable tannins. For anthocyanidins, precursors...

first formed the highly reactive intermediate 57, which subsequently dimerized to yield [2,2]paracyclophane 58. Scheme 11. Pericyclic sequence for the...

recapitulate canonical Wnt signaling using water-soluble bispecific ligands that dimerize Frizzled and Lrp6, which has important implications for the development...

tetra loop and the stem loop 2 of the sgRNA to become binding sites for dimerized MS2 bacteriophage coat proteins. As the hairpins are exposed outside of...

Deng T, Hibi M, Karin M (1996). "c-Jun can recruit JNK to phosphorylate dimerization partners via specific docking interactions". Cell. 87 (5): 929–39. doi:10...

catalysis involving alkyne complexes. Cuprous chloride also catalyzes the dimerization of acetylene to vinylacetylene, once used as a precursor to various polymers...

and XPF interact to promote dimerization of the two proteins. There is no catalytic activity in the absence of dimerization. Indeed, although the catalytic...

conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. The proteolytic cleavage of this protein is...