DicF RNA

DicF RNA
Predicted secondary structure and sequence conservation of DicF
Identifiers
SymbolDicF
RfamRF00039
Other data
RNA typeGene; antisense
DomainBacteria
GOGO:0003729
SOSO:0000644
PDB structuresPDBe

DicF RNA is a non-coding RNA that is an antisense inhibitor of cell division gene ftsZ.[1] DicF is bound by the Hfq protein which enhances its interaction with its targets. Pathogenic E. coli strains possess multiple copies of sRNA DicF in their genomes, while non-pathogenic strains do not. DicF and Hfq are both necessary to reduce FtsZ protein levels, leading to cell filamentation under anaerobic conditions.[2]

References

  1. ^ Faubladier M, Bouché JP (February 1994). "Division inhibition gene dicF of Escherichia coli reveals a widespread group of prophage sequences in bacterial genomes". Journal of Bacteriology. 176 (4): 1150–1156. doi:10.1128/jb.176.4.1150-1156.1994. PMC 205167. PMID 7508908.
  2. ^ Murashko ON, Lin-Chao S (September 2017). "Escherichia coli responds to environmental changes using enolasic degradosomes and stabilized DicF sRNA to alter cellular morphology". Proceedings of the National Academy of Sciences of the United States of America. 114 (38): E8025–E8034. Bibcode:2017PNAS..114E8025M. doi:10.1073/pnas.1703731114. PMC 5617263. PMID 28874523.

Further reading

  • Tétart F, Bouché JP (March 1992). "Regulation of the expression of the cell-cycle gene ftsZ by DicF antisense RNA. Division does not require a fixed number of FtsZ molecules". Molecular Microbiology. 6 (5): 615–620. doi:10.1111/j.1365-2958.1992.tb01508.x. PMID 1372677. S2CID 46203983.
  • Bouché F, Bouché JP (July 1989). "Genetic evidence that DicF, a second division inhibitor encoded by the Escherichia coli dicB operon, is probably RNA". Molecular Microbiology. 3 (7): 991–994. doi:10.1111/j.1365-2958.1989.tb00249.x. PMID 2477663. S2CID 22433247.
  • Cam K, Cuzange A, Bouché JP (July 1995). "Sigma S-dependent overexpression of ftsZ in an Escherichia coli K-12 rpoB mutant that is resistant to the division inhibitors DicB and DicF RNA". Molecular & General Genetics. 248 (2): 190–194. doi:10.1007/BF02190800. PMID 7651342. S2CID 34067129.
  • Faubladier M, Cam K, Bouché JP (April 1990). "Escherichia coli cell division inhibitor DicF-RNA of the dicB operon. Evidence for its generation in vivo by transcription termination and by RNase III and RNase E-dependent processing". Journal of Molecular Biology. 212 (3): 461–471. doi:10.1016/0022-2836(90)90325-G. PMID 1691299.
Stub icon

This molecular or cell biology article is a stub. You can help Wikipedia by adding missing information.

Content Disclaimer

Informasi ini disarikan dari Wikipedia dan disajikan kembali untuk tujuan edukasi. Konten tersedia di bawah lisensi CC BY-SA 3.0. Kami tidak bertanggung jawab atas ketidakakuratan data yang bersumber dari kontribusi publik tersebut.

  1. The information displayed on this website is sourced in part or in whole from Wikipedia and has been adapted for the purpose of restating it. We strive to provide accurate and relevant information, however:
  2. There is no guarantee of absolute accuracy. Wikipedia is an open, collaborative project that can be edited by anyone, so information is subject to change.
  3. It is not intended to constitute professional advice. The content displayed is for informational and educational purposes only. For important decisions (e.g., medical, legal, or financial), please consult a professional.
  4. Content copyright. Wikipedia is licensed under the Creative Commons Attribution-ShareAlike License (CC BY-SA). This means that content may be reused with appropriate attribution and shared under a similar license.
  5. Responsible use. Any risk arising from the use of information from this website is entirely the responsibility of the user.