DPH5

DPH5
Identifiers
AliasesDPH5, CGI-30, HSPC143, NPD015, AD-018, diphthamide biosynthesis 5
External IDsOMIM: 611075; MGI: 1916990; HomoloGene: 6471; GeneCards: DPH5; OMA:DPH5 - orthologs
Orthologs
SpeciesHumanMouse
Entrez

51611

69740

Ensembl

ENSG00000117543

ENSMUSG00000033554

UniProt

Q9H2P9

Q9CWQ0

RefSeq (mRNA)

NM_001077394
NM_001077395
NM_015958

NM_027193

RefSeq (protein)

NP_001070862
NP_001070863
NP_057042

NP_081469

Location (UCSC)Chr 1: 100.99 – 101.03 MbChr 3: 115.89 – 115.93 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Diphthine synthase is an enzyme that in humans is encoded by the DPH5 gene.[5][6]

This gene encodes a component of the diphthamide synthesis pathway. Diphthamide is a post-translationally modified histidine residue found only on translation elongation factor 2. It is conserved from archaebacteria to humans, and is targeted by diphtheria toxin and Pseudomonas exotoxin A to halt cellular protein synthesis.

The yeast and Chinese hamster homologs of this protein catalyze the trimethylation of the histidine residue on elongation factor 2, resulting in a diphthine moiety that is subsequently amidated to yield diphthamide. Multiple transcript variants encoding different isoforms have been found for this gene.[6]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000117543 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000033554 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Liu S, Milne GT, Kuremsky JG, Fink GR, Leppla SH (Oct 2004). "Identification of the proteins required for biosynthesis of diphthamide, the target of bacterial ADP-ribosylating toxins on translation elongation factor 2". Mol Cell Biol. 24 (21): 9487–97. doi:10.1128/MCB.24.21.9487-9497.2004. PMC 522255. PMID 15485916.
  6. ^ a b "Entrez Gene: DPH5 DPH5 homolog (S. cerevisiae)".

Further reading


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