Corey–Pauling rules
 | This article relies largely or entirely on a single source. (February 2026) |
In biochemistry, the Corey–Pauling rules are a set of three basic statements that govern the secondary nature of proteins, in particular, the CO-NH peptide link. They were originally proposed by Robert Corey and Linus Pauling.[1]
The rules are as follows:
- The atoms in a peptide link all lie on the same plane.
- The nitrogen, hydrogen, and oxygen atoms in a hydrogen bond are approximately in a straight line.
- The carbon-oxygen and nitrogen-hydrogen groups are all involved in bonding.
References
- ^ John Daintith, ed. (2008). A Dictionary of Chemistry (6th ed.). Oxford University Press. ISBN 9780199204632.
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