Chromosome engineering

Chromosome engineering is "the controlled generation of chromosomal deletions, inversions, or translocations with defined endpoints."[1] By combining chromosomal translocation, chromosomal inversion, and chromosomal deletion, chromosome engineering has been shown to identify the underlying genes that cause certain diseases in mice. In coming years, it is very likely that chromosomal engineering will be able to do the same identification for diseases in humans, as well as all other organisms.[2]

The Three Types of Chromosome Engineering

chromosomal deletion chromosomal inversion chromosomal translocation
Chromosomal deletion is a mutation (a genetic aberration) in which a part of a chromosome or a sequence of DNA is missing.[citation needed] Chromosomal inversion is a chromosome rearrangement in which a segment of a chromosome is reversed end to end.[citation needed] Chromosomal translocation is a chromosome abnormality caused by rearrangement of parts between nonhomologous chromosomes.[citation needed]

Experiments of Chromosome Engineering

In an experiment pertaining to chromosome engineering that was conducted in 2006, it was found that chromosome engineering can be effectively used as a method of identifying the causes of genetic disorders such as the continuous gene and aneuploidy syndromes. The experiment was conducted by infecting mice with the human disease, ES, to see the effectiveness of chromosomal engineering in the gene identification of those diseases. After much experimenting, it was found that manipulating chromosomes, or chromosome engineering, is an excellent and efficient method of determining underlying genes in genetic orders and diseases.[citation needed]

In the future, chromosome engineering will experiment in removing more common disorders such as asthma, diabetes, and cancer. If it can be recognized by the medical community as effective and safe, it should be able to be used regularly in the near future.[citation needed]

See also

References

  1. ^ "Chromosome engineering". Glossary. For: Carlson, Corey M.; Largaespada, David A. (2005). "Insertional mutagenesis in mice: New perspectives and tools". Nature Reviews Genetics. 6 (7): 568–80. doi:10.1038/nrg1638. PMID 15995698. S2CID 3194633.
  2. ^ Ramirez-Solis, Ramlro; Liu, Pentao; Bradley, Allan (1995). "Chromosome engineering in mice". Nature. 378 (6558): 720–4. Bibcode:1995Natur.378..720R. doi:10.1038/378720a0. PMID 7501018. S2CID 4325102.

Content Disclaimer

Informasi ini disarikan dari Wikipedia dan disajikan kembali untuk tujuan edukasi. Konten tersedia di bawah lisensi CC BY-SA 3.0. Kami tidak bertanggung jawab atas ketidakakuratan data yang bersumber dari kontribusi publik tersebut.

  1. The information displayed on this website is sourced in part or in whole from Wikipedia and has been adapted for the purpose of restating it. We strive to provide accurate and relevant information, however:
  2. There is no guarantee of absolute accuracy. Wikipedia is an open, collaborative project that can be edited by anyone, so information is subject to change.
  3. It is not intended to constitute professional advice. The content displayed is for informational and educational purposes only. For important decisions (e.g., medical, legal, or financial), please consult a professional.
  4. Content copyright. Wikipedia is licensed under the Creative Commons Attribution-ShareAlike License (CC BY-SA). This means that content may be reused with appropriate attribution and shared under a similar license.
  5. Responsible use. Any risk arising from the use of information from this website is entirely the responsibility of the user.