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homolog is an essential regulator of cell division that is encoded by the CDC20 gene in humans. To the best of current knowledge its most important function...

subunit, CDC20 allows APC to degrade substrates such as anaphase inhibitors (Pdsp1) at the beginning of anaphase, on the other hand when CDC20 is substituted...

include either Cdc20 or Mad1. Mad1 and Cdc20 bind Mad2 in an identical fashion. Mad2 uses the same site to bind either Mad1 or Cdc20 and, thus, can only...

essential for Mad2-Cdc20 complex formation in vivo but not in vitro. In vivo, Mad1 acts as a competitive inhibitor of the Mad2-Cdc20 complex. Mad1 is phosphorylated...

human cells, binding of BUBR1 to CDC20 requires prior binding of MAD2 to CDC20, so it is possible that the MAD2-CDC20 subcomplex acts as an initiator for...

ligase responsible for triggering events of late mitosis. In early mitosis, Cdc20 levels rise and APC/C binds to form active APC/CCdc20. This then leads to...

Cdh1 (cdc20 homolog 1) is one of the substrate adaptor proteins of the anaphase-promoting complex (APC) in the budding yeast Saccharomyces cerevisiae...

association with Cdc20 (APC-Cdc20) ubiquitinates and targets mitotic cyclins (Clb2) for degradation at initial phase. Simultaneously, APC-Cdc20 mediates degradation...

stage of the cell cycle. Cytokinesis happens only after APC binds with CDC20.[citation needed] This allows for the separation of chromosomes and myosin...

unattached kinetochores, a complex consisting of BubR1, Bub3, and Cdc20 interact with the Mad2-Cdc20 complex to inhibit the APC, thus inhibiting the formation...

activation of the SAC Bub1 directly phosphorylates APC/C's coactivator Cdc20. This phosphorylation event is probably achieved in complex with Bub3, which...

Prophase Prometaphase Metaphase Telophase Cytoskeleton Anaphase I Anaphase II Cdc20 "Chromosome condensation through mitosis". Science Daily. Retrieved 12 June...

complex (APC), also known as the cyclosome, a ubiquitin-ligase. The active, CDC20-bound APC (APC/CCDC20) targets mitotic cyclins for degradation starting...

to chromosome 14. MAD2L1 has been shown to interact with: ADAM17, BUB1B, CDC20, CDC27 and Estrogen receptor beta, MAD2L2, Mad1, and UBD. GRCh38: Ensembl...

binding of CDC20 to APC/C is required for the ubiquitination of securin. A protein called hMAD2 can form an inactive trimer with APC and CDC20, forming...

Additional work shows that the APC/C-CDC20 remains in control of cell cycle and RZZ complex remains in control of APC/C-CDC20 despite the absence of MAD1/2....

"cell division cycle") followed by an identifying number, e.g. cdc25 or cdc20. Cyclins form the regulatory subunits and CDKs the catalytic subunits of...

moment, the checkpoint proteins that bind to and inhibit Cdc20 (Mad1-Mad2 and BubR1), release Cdc20, which binds and activates APC/CCdc20, and this complex...

CRT resistance. BUB1B has been shown to interact with: AP2B1 BRCA2 BUB3 CDC20 MAD2L1 CBP SIRT2 PLK1 PP2A-B56 HDAC1 HDAC2 / HDAC3 SNCG GRCh38: Ensembl...

structure of mad1-mad2 reveals a conserved mad2 binding motif in mad1 and cdc20. Identifiers Symbol HORMA Pfam PF02301 InterPro IPR003511 SCOP2 1duj / SCOPe...

1159/000134721. PMID 9605851. Farruggio DC, Townsley FM, Ruderman JV (1999). "Cdc20 associates with the kinase aurora2/Aik". Proc. Natl. Acad. Sci. U.S.A. 96...

independent research careers". As a Whitehead Fellow, her team discovered that CDC20 plays a crucial role in cell division. Her Whitehead team identified an...

"Activation of the human anaphase-promoting complex by proteins of the CDC20/Fizzy family". Current Biology. 8 (22): 1207–S4. Bibcode:1998CBio....8.1207K...

cell-specific centrosomal protein associated with the seventh WD motif of Cdc20". The Journal of Biological Chemistry. 279 (40): 42128–38. doi:10.1074/jbc...

to Cdc20 (APC/C-cdc20) marks Securin (anaphase inhibitor) for degradation by the proteasome. Securin is cleaved at anaphase, following APC/C-cdc20 mediated...

have been identified. CDC16 has been shown to interact with CDC27 and CDC20. GRCh38: Ensembl release 89: ENSG00000130177 – Ensembl, May 2017 GRCm38:...

Centre, former hospital in Novena, Singapore Cell-division cycle in biology cdc20 cdc25 Cdc42, cell-division cycle protein Cholesterol-dependent cytolysin...

APAF1, ARPC1A, ARPC1B, ATG16L1, BOP1, BRWD1, BRWD3, BTRC, BUB3, C6orf11, CDC20, CDC40, CDRT1, CHAF1B, CIAO1, CIRH1A, COPA, COPB2, CORO1A, CORO1B, CORO1C...

ubiquitinated and hydrolysed, releasing separase for dephosphorylation by the APC-Cdc20 complex. Active separase can then cleave Scc1 for release of the sister...

checkpoint complex which is composed of four different proteins known as Mad2, Cdc20, BubR1, and Bub3 in humans. When the mitotic checkpoint complex is formed...

association with Cdc20 (APC-Cdc20) ubiquitinates and targets mitotic cyclins (Clb2) for degradation at initial phase. Simultaneously, APC-Cdc20 mediates degradation...

is recognized by the Anaphase-Promoting Complex (APC) bound primarily to Cdc20 (Cdh1 is also an activating substrate of APC). The APCCdc20 complex ubiquitinates...

protein, Cdh1. This is a result of TPX2 being bound directly by Cdh1, and not Cdc20 or any other substrate of APC/CCdh1, and designated for degradation by APC/C...

protein 1 subunit gamma CCT6A CCT6A T-complex protein 1 subunit zeta CDC20 CDC20 Cell Division Cycle 20 CDC37 CDC37 Cell Division Cycle 37 CDC5L CDC5L...

regulation of mitotic checkpoint protein complex via phosphorylation of CDC20 and MAD2L1. Plays an active role in chromatin condensation during the first...

anaphase-promoting complex (APC). The APC, which is activated by Fizzy-Cdc20 family proteins, is a cell cycle ubiquitin-protein ligase (E3) that degrades...

activated, which upon activation degrade securing. The APC is activated by CDC20, a protein that is silenced by the mitotic checkpoint complex (MCC). Of...

the degradation of Pds1 (anaphase inhibitor). And what is more, CDC4 and CDC20, an activator of APC, interact genetically. Cdc4 recruits several other...

dephosphorylation of Sic1. Destruction of Clb5 and Clb6 is usually mediated by APC-Cdc20. Studies have also shown that cells lacking Clb5 and Clb6 have dramatically...

enter mitosis. When STAU1 protein interacts with APC/C adapter proteins Cdc20 and Cdh1, proteasomal degradation is promoted in mitotic cells. These examples...

coactivators. ANAPC7 has been shown to interact with ANAPC1, ANAPC4, CDC27 and CDC20. GRCh38: Ensembl release 89: ENSG00000196510 – Ensembl, May 2017 GRCm38:...

been shown to interact with: Ataxia telangiectasia and Rad3 related, BUB3, CDC20, CDH1, CHD3, CHD4, DNMT1, EED, EZH2 and FKBP3, GATA4, GTF2I, HDAC10, HDAC1...

interact with: Androgen receptor, BCL6, BTG2, BUB1B, BUB1, BUB3, CBFA2T3, CDC20, CDH1, CHD3, CHD4, COUP-TFII, CTBP1, DDX17, DDX5, DNMT3A, DNMT3L, Death-associated...

mitotic inhibitor-1 (Emi1), which is a mitotic regulator that interacts with Cdc20 and inhibits the anaphase promoting complex. Moreover, Emi1 also assembles...

Prosperini E, Helin K, Musacchio A (November 2001). "Mad2 binding to Mad1 and Cdc20, rather than oligomerization, is required for the spindle checkpoint". The...

O60729 2570 CDC14C HGNC:22427; A4D256 2571 CDC16 HGNC:1720; Q13042 2572 CDC20 HGNC:1723; Q12834 2573 CDC20B HGNC:24222; Q86Y33 2574 CDC23 HGNC:1724; Q9UJX2...

2001). "The anaphase inhibitor Pds1 binds to the APC/C-associated protein Cdc20 in a destruction box-dependent manner". Current Biology. 11 (17): 1347–52...

inhibition of the APC/C in HeLa cells is mediated by a complex of BUBR1, BUB3, CDC20, and MAD2. Journal of cell biology. 2001 Sep 3;154(5):925-36. According...

the Kip/Cip family of CDK-inhibitor proteins. Cyclin-A1 interacts with: CDC20, Cyclin-dependent kinase 2, E2F1, GNB2L1, GPS2, MYBL2, and Retinoblastoma...

interact with: ANAPC10, ANAPC11, ANAPC1, ANAPC4, ANAPC5, ANAPC7, CDC16, CDC20, CDC23, CDH1, FZR1, MAD2L1 and PIN1. GRCh38: Ensembl release 89: ENSG00000004897...