CSTF1

CSTF1
Identifiers
AliasesCSTF1, CstF-50, CstFp50, cleavage stimulation factor subunit 1
External IDsOMIM: 600369; MGI: 1914587; HomoloGene: 1012; GeneCards: CSTF1; OMA:CSTF1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez

1477

67337

Ensembl

ENSG00000101138

ENSMUSG00000027498

UniProt

Q05048

Q99LC2

RefSeq (mRNA)

NM_001033521
NM_001033522
NM_001324

NM_024199

RefSeq (protein)

NP_001028693
NP_001028694
NP_001315

NP_077161

Location (UCSC)Chr 20: 56.39 – 56.41 MbChr 2: 172.21 – 172.22 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Cleavage stimulation factor 50 kDa subunit is a protein that in humans is encoded by the CSTF1 gene.[5][6][7]

This gene encodes one of three subunits which combine to form cleavage stimulation factor (CSTF). CSTF is involved in the polyadenylation and 3' end cleavage of pre-mRNAs. Similar to mammalian G protein beta subunits, this protein contains transducin-like repeats. Several transcript variants with different 5' UTR, but encoding the same protein, have been found for this gene.[7]

Interactions

CSTF1 has been shown to interact with BARD1.[6][8]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000101138 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000027498 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Takagaki Y, Manley JL (November 1992). "A human polyadenylation factor is a G protein beta-subunit homologue". The Journal of Biological Chemistry. 267 (33): 23471–4. doi:10.1016/S0021-9258(18)35861-7. PMID 1358884.
  6. ^ a b Kleiman FE, Manley JL (March 2001). "The BARD1-CstF-50 interaction links mRNA 3' end formation to DNA damage and tumor suppression". Cell. 104 (5): 743–53. doi:10.1016/S0092-8674(01)00270-7. PMID 11257228. S2CID 15022237.
  7. ^ a b "Entrez Gene: CSTF1 cleavage stimulation factor, 3' pre-RNA, subunit 1, 50kDa".
  8. ^ Kleiman FE, Manley JL (September 1999). "Functional interaction of BRCA1-associated BARD1 with polyadenylation factor CstF-50". Science. 285 (5433): 1576–9. doi:10.1126/science.285.5433.1576. PMID 10477523.

Further reading


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