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CIRBP
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1X5S
Identifiers
Aliases	CIRBP, CIRP, cold inducible RNA binding protein
External IDs	OMIM: 602649; MGI: 893588; HomoloGene: 980; GeneCards: CIRBP; OMA:CIRBP - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	1,274,880 bp
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)
End	80,172,786 bp
RNA expression pattern
	Top expressed in
	tibia; ; corpus epididymis; ; caput epididymis; ; parietal pleura; ; germinal epithelium; ; right hemisphere of cerebellum; ; right uterine tube; ; anterior pituitary; ; middle temporal gyrus; ; left ovary;
	Top expressed in
	neural layer of retina; ; lip; ; cerebellar cortex; ; molar; ; ventricular zone; ; spermatocyte; ; superior frontal gyrus; ; primary visual cortex; ; dorsomedial hypothalamic nucleus; ; paraventricular nucleus of hypothalamus;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	translation repressor activity; nucleic acid binding; protein binding; small ribosomal subunit rRNA binding; mRNA 3'-UTR binding; RNA binding; poly(U) RNA binding;
Cellular component	cytoplasm; cytoplasmic stress granule; nucleolus; nucleus; nucleoplasm; spliceosomal complex; ribonucleoprotein complex;
Biological process	stress granule assembly; response to cold; mRNA stabilization; response to UV; positive regulation of translation; negative regulation of translation; positive regulation of mRNA splicing, via spliceosome;
	Sources:Amigo / QuickGO
Orthologs
	1153
	12696
	ENSG00000099622
	ENSMUSG00000045193
	Q14011; Q53XX5
	P60824
	NM_001280; NM_001300815; NM_001300829
	NM_007705
	NP_001271; NP_001287744; NP_001287758; NP_001271.1
NP_031731; NP_001366350; NP_001366351; NP_001366352; NP_001366353;
	NP_001366354
	Wikidata
View/Edit Human	View/Edit Mouse

Cold-inducible RNA-binding protein is a protein that in humans is encoded by the CIRBP gene.^[5]^[6]^[7] The cold-inducible, RNA-binding protein CIRBP plays a critical role in controlling the cellular response upon confronting a variety of cellular stresses, including short wavelength ultraviolet light, hypoxia, and hypothermia. It is thought to be involved in DNA repair.^[8]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000099622 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000045193 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Nishiyama H, Higashitsuji H, Yokoi H, Itoh K, Danno S, Matsuda T, et al. (December 1997). "Cloning and characterization of human CIRP (cold-inducible RNA-binding protein) cDNA and chromosomal assignment of the gene". Gene. 204 (1–2): 115–120. doi:10.1016/S0378-1119(97)00530-1. PMID 9434172.
^ Nishiyama H, Itoh K, Kaneko Y, Kishishita M, Yoshida O, Fujita J (May 1997). "A glycine-rich RNA-binding protein mediating cold-inducible suppression of mammalian cell growth". The Journal of Cell Biology. 137 (4): 899–908. doi:10.1083/jcb.137.4.899. PMC 2139845. PMID 9151692.
^ "Entrez Gene: CIRBP cold inducible RNA binding protein".
^ Firsanov D, Zacher M, Tian X, Sformo TL, Zhao Y, Tombline G, et al. (November 2024). "DNA repair and anti-cancer mechanisms in the long-lived bowhead whale". bioRxiv 10.1101/2023.05.07.539748.

External links

Human CIRBP genome location and CIRBP gene details page in the UCSC Genome Browser.

Sheikh MS, Carrier F, Papathanasiou MA, Hollander MC, Zhan Q, Yu K, et al. (October 1997). "Identification of several human homologs of hamster DNA damage-inducible transcripts. Cloning and characterization of a novel UV-inducible cDNA that codes for a putative RNA-binding protein". The Journal of Biological Chemistry. 272 (42): 26720–26726. doi:10.1074/jbc.272.42.26720. PMID 9334257.
Nishiyama H, Danno S, Kaneko Y, Itoh K, Yokoi H, Fukumoto M, et al. (January 1998). "Decreased expression of cold-inducible RNA-binding protein (CIRP) in male germ cells at elevated temperature". The American Journal of Pathology. 152 (1): 289–296. PMC 1858111. PMID 9422546.
Lee J, Bedford MT (March 2002). "PABP1 identified as an arginine methyltransferase substrate using high-density protein arrays". EMBO Reports. 3 (3): 268–273. doi:10.1093/embo-reports/kvf052. PMC 1084016. PMID 11850402.
Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, et al. (December 2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proceedings of the National Academy of Sciences of the United States of America. 99 (26): 16899–16903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Hamid AA, Mandai M, Fujita J, Nanbu K, Kariya M, Kusakari T, et al. (July 2003). "Expression of cold-inducible RNA-binding protein in the normal endometrium, endometrial hyperplasia, and endometrial carcinoma". International Journal of Gynecological Pathology. 22 (3): 240–247. doi:10.1097/01.PGP.0000070851.25718.EC. PMID 12819390. S2CID 22639276.
Wellmann S, Bührer C, Moderegger E, Zelmer A, Kirschner R, Koehne P, et al. (April 2004). "Oxygen-regulated expression of the RNA-binding proteins RBM3 and CIRP by a HIF-1-independent mechanism". Journal of Cell Science. 117 (Pt 9): 1785–1794. doi:10.1242/jcs.01026. PMID 15075239.
Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, et al. (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–1178. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Lim J, Hao T, Shaw C, Patel AJ, Szabó G, Rual JF, et al. (May 2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–814. doi:10.1016/j.cell.2006.03.032. PMID 16713569. S2CID 13709685.
Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Molecular Systems Biology. 3 (1) 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.

This article on a gene on human chromosome 19 is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000099622 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000045193 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[Nishiyama_1997-5] Nishiyama H, Higashitsuji H, Yokoi H, Itoh K, Danno S, Matsuda T, et al. (December 1997). "Cloning and characterization of human CIRP (cold-inducible RNA-binding protein) cDNA and chromosomal assignment of the gene". Gene. 204 (1–2): 115–120. doi:10.1016/S0378-1119(97)00530-1. PMID 9434172.

[Nishiyama_1997a-6] Nishiyama H, Itoh K, Kaneko Y, Kishishita M, Yoshida O, Fujita J (May 1997). "A glycine-rich RNA-binding protein mediating cold-inducible suppression of mammalian cell growth". The Journal of Cell Biology. 137 (4): 899–908. doi:10.1083/jcb.137.4.899. PMC 2139845. PMID 9151692.

[entrez-7] "Entrez Gene: CIRBP cold inducible RNA binding protein".

[8] Firsanov D, Zacher M, Tian X, Sformo TL, Zhao Y, Tombline G, et al. (November 2024). "DNA repair and anti-cancer mechanisms in the long-lived bowhead whale". bioRxiv 10.1101/2023.05.07.539748.

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CIRBP

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