CACNA2D4

CACNA2D4
Identifiers
AliasesCACNA2D4, RCD4, calcium voltage-gated channel auxiliary subunit alpha2delta 4
External IDsOMIM: 608171; MGI: 2442632; HomoloGene: 26544; GeneCards: CACNA2D4; OMA:CACNA2D4 - orthologs
Orthologs
SpeciesHumanMouse
Entrez

93589

319734

Ensembl

ENSG00000151062
ENSG00000284953

ENSMUSG00000041460

UniProt

Q7Z3S7

Q5RJF7

RefSeq (mRNA)

NM_001005737
NM_001005766
NM_172364

NM_001033382
NM_001347427
NM_001362214

RefSeq (protein)

NP_758952

Location (UCSC)Chr 12: 1.79 – 1.92 MbChr 6: 119.21 – 119.33 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Calcium channel, voltage-dependent, alpha 2/delta subunit 4 is a protein that in humans is encoded by the CACNA2D4 gene.[5]

Function

This gene encodes a member of the alpha-2/delta subunit family, a protein in the voltage-dependent calcium channel complex. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization and consist of a complex of alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio. Various versions of each of these subunits exist, either expressed from similar genes or the result of alternative splicing. Research on a highly similar protein in rabbit suggests the protein described in this record is cleaved into alpha-2 and delta subunits. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized.[5]

References

  1. ^ a b c ENSG00000284953 GRCh38: Ensembl release 89: ENSG00000151062, ENSG00000284953 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000041460 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b "Entrez Gene: Calcium channel, voltage-dependent, alpha 2/delta subunit 4".

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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